{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:26:15Z","timestamp":1783596375689,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>To define the mechanism(s) for the decrease of somatomedin concentrations in acute protein malnutrition, we have assessed the relationships between serum immunoreactive somatomedin-C\/insulin-like growth factor-I (Sm-C\/IGF-I), serum immunoreactive GH and total (MgCl2-treated homogenates) as well as free (water-treated homogenates) liver somatogenic (GH) binding sites in growing rats fed a 5% protein diet for 12 or 24 h and given an s.c. injection(s) of rat GH (rGH) or saline. Control rats were fed a 15% protein diet and injected with rGH or saline.<\/jats:p>\n                  <jats:p>After 12 and 24 h of protein restriction, body weight was 6\u00b79 and 8\u00b72% below controls respectively (P &amp;lt; 0\u00b7001), while Sm-C\/IGF-I concentrations were reduced by 58 and 66% respectively (P &amp;lt; 0\u00b7001 vs controls). Serum GH concentrations were not affected by the low protein intake. Furthermore, injection(s) of 50\u2013100 \u03bcg rGH failed to raise serum Sm-C\/IGF-I concentrations in the protein-deficient animals. The number of total and free GH-binding sites was modestly (15\u201320%) decreased at 12 and 24 h in the protein-restricted rats. Serum Sm-C\/IGF-I concentrations correlated weakly with free and total binding sites (r = 0\u00b748 and 0\u00b738 respectively). Affinity constants of GH-binding sites were not changed by protein restriction.<\/jats:p>\n                  <jats:p>The profound reduction in Sm-C\/IGF-I concentrations within a few hours of beginning protein restriction, and the discordance between this reduction and the small decline in somatogenic binding sites, suggests that, in addition to GH receptor loss, a postreceptor defect may participate in the GH resistance occurring in the early stages of protein deficiency.<\/jats:p>\n                  <jats:p>J. Endocr. (1988) 118, 113\u2013120<\/jats:p>","DOI":"10.1677\/joe.0.1180113","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:52:58Z","timestamp":1229017978000},"page":"113-120","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":37,"title":["Early changes in serum concentrations of somatomedin-C induced by dietary protein deprivation in rats: contributions of growth hormone receptor and post-receptor defects"],"prefix":"10.1530","volume":"118","author":[{"given":"D.","family":"Maiter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. E.","family":"Underwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Fliesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Gerard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-M.","family":"Ketelslegers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/118\/1\/joe_118_1_015.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/118\/1\/113\/97791\/joe_118_1_015.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/118\/1\/113\/97791\/joe_118_1_015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:07:50Z","timestamp":1783595270000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/118\/1\/113\/16233\/Early-changes-in-serum-concentrations-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,7,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.1180113","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1988,7,1]]}}}