{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:26:39Z","timestamp":1783596399205,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Using hypophysectomized rats, it has been shown that DNA polymerase-\u03b2 activity in the adrenal gland and testis is largely influenced by pituitary trophic hormones. Sucrose gradient centrifugation of thyroid extracts revealed three peaks of DNA polymerase-\u03b2 activity sedimenting at 3\u00b73S, 7\u00b73S and 12S. Of these, hypophysectomy induced a decrease in the 3\u00b73S DNA polymerase-\u03b2, whereas other molecular forms were affected only slightly. DNA polymerase-\u03b1 and -\u03b3 activities were unaffected by hypophysectomy. These changes in DNA polymerase-\u03b2 caused by hypophysectomy were reversed by daily i.p. injection of TSH. Furthermore, stimulation of the thyroid by excess TSH induced by the administration of 1-methyl-2-mercaptoimidazole resulted in an increase of all forms of thyroid DNA polymerase-\u03b2.<\/jats:p>\n                  <jats:p>These results show that the level of DNA polymerase is relatively constant after hypophysectomy but that DNA polymerase-\u03b2 in the rat thyroid gland is also modulated by TSH mainly through the change of activity of the polymerase-\u03b2 which sediments at 3\u00b73S.<\/jats:p>\n                  <jats:p>J. Endocr. (1988) 119, 303\u2013308<\/jats:p>","DOI":"10.1677\/joe.0.1190303","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:52:58Z","timestamp":1229017978000},"page":"303-308","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":4,"title":["Hormonal regulation of DNA polymerase-\u03b2 activity in the rat thyroid gland"],"prefix":"10.1530","volume":"119","author":[{"given":"A.","family":"Nagasaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ohyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Iwase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ohtani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Masunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kawabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/119\/2\/joe_119_2_018.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/119\/2\/303\/97968\/joe_119_2_018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/119\/2\/303\/97968\/joe_119_2_018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:10:25Z","timestamp":1783595425000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/119\/2\/303\/16290\/Hormonal-regulation-of-DNA-polymerase-activity-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,11,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,11,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.1190303","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1988,11,1]]}}}