{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:24:07Z","timestamp":1783607047960,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The effect of synthetic human growth hormone-releasing hormone(1\u201340) (hGHRH-40) on the function of the endocrine pancreas and on glucose homeostasis in lean and genetically obese-diabetic (ob\/ob) mice and normal rats has been examined. The addition of 1 \u03bcmol hGHRH-40\/1 to incubated islets from normal lean mice increased insulin release by 90 and 37% at 5\u00b76 and 16\u00b77 mmol glucose\/l respectively. Lower concentrations of hGHRH-40 did not affect insulin release. hGHRH-40 (1 \u03bcmol\/l) increased pancreatic polypeptide release by 50% at 5\u00b76 mmol glucose\/l. A range of concentrations of hGHRH-40 (1 nmol\/l\u20131 \u03bcmol\/l) reduced glucagon release by 42\u201373% at 5\u00b76 mmol glucose\/l, and by 38\u201370% at 16\u00b77 mmol glucose\/l. Somatostatin release was increased (eightfold) by 1 \u03bcmol hGHRH-40\/1 at 5\u00b76 mmol glucose\/l, but at 1 nmol hGHRH-40\/l somatostatin release was reduced (by &amp;gt; 50%). At 16\u00b77 mmol glucose\/litre 0\u00b701\u20131 \u03bcmol hGHRH-40\/l increased somatostatin release (three- to fourfold), but 1 nmol hGHRH-40\/l produced a reduction of 50%. In vivo, administration of hGHRH-40 (50 \u03bcg\/kg body weight i.p.) to fasted lean and ob\/ob mice did not alter basal plasma concentrations of glucose and insulin, or the glucose and insulin responses to a concomitant i.p. glucose challenge. Intravenous injection of hGHRH-40 (20 \u03bcg\/kg body weight) to anaesthetized rats increased plasma concentrations of insulin in the hepatic portal vein. A lower dose of hGHRH-40 (0\u00b72 \u03bcg\/kg) was ineffective, and neither dose of hGHRH-40 altered plasma glucose. The results indicate that hGHRH-40 exerts dose-dependent effects on the secretion of islet hormones, but this does not appear to be sufficient to produce measurable effects on plasma glucose homeostasis.<\/jats:p>\n                  <jats:p>Journal of Endocrinology (1989) 123, 19\u201324<\/jats:p>","DOI":"10.1677\/joe.0.1230019","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T18:11:20Z","timestamp":1229019080000},"page":"19-24","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":7,"title":["Effects of growth hormone-releasing hormone on the secretion of islet hormones and on glucose homeostasis in lean and genetically obese-diabetic (\n                    <i>ob\/ob<\/i>\n                    ) mice and normal rats"],"prefix":"10.1530","volume":"123","author":[{"given":"C. J.","family":"Bailey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. C.","family":"Wilkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. R.","family":"Flatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Conlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. D.","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/123\/1\/joe_123_1_004.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/123\/1\/19\/99016\/joe_123_1_004.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/123\/1\/19\/99016\/joe_123_1_004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:53:57Z","timestamp":1783605237000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/123\/1\/19\/16649\/Effects-of-growth-hormone-releasing-hormone-on-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,10,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,10,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.1230019","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1989,10,1]]}}}