{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:24:05Z","timestamp":1783607045158,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Blood pressure and selected putatively influential hormones were measured in Brattleboro rats which were without diabetes insipidus and which were subjected to various manipulations in dietary sodium intake. Rats fed a control diet from weaning to 16 weeks of age showed a slow increase in blood pressure whereas rats fed a sodium-enriched diet for the same period exhibited sustained hypertension (115\u00b13 versus 169\u00b15 (s.e.m.) mmHg). In animals fed a sodium-enriched diet plasma concentrations of antidiuretic hormone (ADH) were significantly increased from 55\u00b18 to 108\u00b15 fmol\/l. Rats fed the control diet from weaning (group A) and subsequently maintained on that diet or changed to a sodium-enriched diet or sodium-deficient diet showed no differences in their blood pressure. Plasma hormone concentrations were similar in these groups, with the exception of aldosterone suppression in rats switched from control to a sodium-enriched diet (0\u00b726\u00b10\u00b704 versus 0\u00b708\u00b10\u00b703 nmol\/l; P &amp;lt;0\u00b7001). Animals fed the sodium-enriched diet from weaning to 16 weeks of age (group b) and either maintained on that diet or changed to a control diet showed little change in their established hypertension. Transfer to the control diet was associated with increased plasma renin concentrations (PRC) (13\u00b78\u00b12\u00b71 to 122\u00b76\u00b16\u00b72 nmol\/l) and plasma aldosterone concentrations (0\u00b704\u00b10\u00b701 to 0\u00b708\u00b10\u00b701 nmol\/l; P&amp;lt;0\u00b7001) but corticosteroids and ADH concentrations were unchanged. Rats maintained on the sodium-enriched diet from weaning to 16 weeks of age and transfered to a sodium-deficient diet exhibited increases in their established hypertensive blood pressures (maximally 205\u00b14 versus 170\u00b14 mmHg) together with significant increases in PRC (13\u00b78 \u00b12\u00b71 to 297\u00b179 nmol\/l; P&amp;lt; 0\u00b7001), aldosterone (0\u00b704\u00b10\u00b701 to 0\u00b723\u00b10\u00b707 nmol\/l; P &amp;lt;0\u00b7001) and ADH (82\u00b79\u00b115\u00b75 to 466\u00b1118 fmol\/l; P &amp;lt;0\u00b7001), although plasma concentrations of corticosteroids were again unaffected. Thus it would appear that there is a critical developmental stage at which exposure to a sodium-enriched diet subsequently leads to hypertension. Abrupt withdrawal of the sodium-enriched diet produces an exaggerated hypertension involving changes in both ADH and the renin-angiotensin-aldosterone system.<\/jats:p>\n                  <jats:p>Journal of Endocrinology (1990) 127, 243\u2013248<\/jats:p>","DOI":"10.1677\/joe.0.1270243","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T18:11:20Z","timestamp":1229019080000},"page":"243-248","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":2,"title":["Effects of altered dietary sodium intake on hormonal profiles in salt-sensitive hypertensive rats"],"prefix":"10.1530","volume":"127","author":[{"given":"N.","family":"Hazon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. W.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/127\/2\/joe_127_2_009.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/127\/2\/243\/99986\/joe_127_2_009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/127\/2\/243\/99986\/joe_127_2_009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:07:47Z","timestamp":1783606067000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/127\/2\/243\/16963\/Effects-of-altered-dietary-sodium-intake-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,11,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.1270243","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1990,11,1]]}}}