{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:37:29Z","timestamp":1792107449396,"version":"4.4.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It was the dermatologist Aron Lerner who discovered melatonin. The inspiration for his research was a dermatological syllogism.<\/jats:p>\n                  <jats:p>Premise: The pineal gland produces a hormone which inhibits (lightens) pigment cells.<\/jats:p>\n                  <jats:p>Premise: Malignant melanoma is a tumour of pigment cells.<\/jats:p>\n                  <jats:p>Conclusion: The hormone of the pineal gland will inhibit malignant melanoma.<\/jats:p>\n                  <jats:p>Lerner discovered the structure of the skin-lightening hormone, N-acetyl-5-methoxy tryptamine, and he named it melatonin (Lerner, Case, Takahashi et al. 1958).<\/jats:p>\n                  <jats:p>Another group of extraordinarily talented scientists showed that melatonin, in the mammalian pineal gland, has a function which is quite different from its skin-lightening and camouflage role in the frog. First, it was found that melatonin is secreted in the dark, i.e. the skin-lightening hormone of the frog (secreted in bright light to camouflage it) is paradoxically secreted at night in mammals (Wurtman, Axelrod &amp; Phillips, 1963b). Secondly, the mammalian pineal gland is still responsive to light, i.e. there<\/jats:p>","DOI":"10.1677\/joe.0.1280007","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T18:11:20Z","timestamp":1229019080000},"page":"7-11","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":40,"title":["Melatonin and the human gonadotrophin-releasing hormone pulse generator"],"prefix":"10.1530","volume":"128","author":[{"given":"R.","family":"Silman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/128\/1\/joe_128_1_001.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/128\/1\/7\/100045\/joe_128_1_001.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/128\/1\/7\/100045\/joe_128_1_001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:08:43Z","timestamp":1783606123000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/128\/1\/7\/16983\/Melatonin-and-the-human-gonadotrophin-releasing"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,1,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.1280007","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1991,1,1]]}}}