{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:14:26Z","timestamp":1783610066968,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Six experiments were carried out to determine whether dihydrotestosterone (5\u03b1-androstan-17\u03b2-ol-3-one; DHT) acts to inhibit oestradiol (OE2)-induced lordosis behaviour after its metabolic conversion to 5\u03b1-androstane-3\u03b1,17\u03b2-diol (3\u03b1-androstanediol, 3\u03b1-Adiol). In experiments 1 and 2, ovariectomized rats were treated with several doses of DHT or 3\u03b1-Adiol, injected with OE2 and progesterone, and tested for lordosis responsiveness. Significant inhibition of lordosis occurred after a dose of 3\u03b1-Adiol which was approximately threefold less than the effective DHT dose. In experiments 3 and 4, plasma concentrations of DHT and 3\u03b1-Adiol were measured after the injection of these steroids to ovariectomized rats at doses shown to be both sufficient or insufficient to inhibit lordosis. Behaviourally effective dosages of DHT and 3\u03b1-Adiol produced circulating concentrations of 3\u03b1-Adiol greater than those produced by behaviourally ineffective doses of DHT or 3\u03b1-Adiol. At 30 min after injection of DHT (experiment 3), 78\u00b78% of plasma androgens were in the form of 3\u03b1-Adiol, while after injection of 3\u03b1-Adiol, only 7\u00b74% were DHT. When plasma DHT and 3\u03b1-Adiol were measured at 3, 6, 9 and 12 h after steroid injection (experiment 4), plasma levels of 3\u03b1-Adiol produced by the behaviourally subthreshold dose of DHT were significantly lower than levels produced by behaviourally sufficient dosages of DHT or 3\u03b1-Adiol. In experiments 5 and 6, concentrations of DHT and 3\u03b1-Adiol were measured in five brain regions 1 and 6 h after injection of behaviourally sufficient doses of these steroids to ovariectomized females. At 1 h after injection, similar levels of DHT and 3\u03b1-Adiol were measured in DHT- and 3\u03b1-Adiol-injected females, and DHT concentrations in the preoptic area were significantly higher in both groups than in any other brain area. At 6 h, animals injected with DHT had significantly higher levels of DHT in all brain areas combined than did 3\u03b1-Adiol-or vehicle-injected animals. Brain concentrations of 3\u03b1-Adiol were not different between groups injected with DHT, 3\u03b1-Adiol or vehicle at this time. In brain, 34\u00b76% of DHT had been converted to 3\u03b1-Adiol after 1 h and 53\u00b70% of 3\u03b1-Adiol had been converted to DHT. These results suggest that the inhibitory action of DHT on lordosis may be a consequence of its conversion to 3\u03b1-Adiol, and that this conversion may account for the higher behavioural potency of the latter steroid.<\/jats:p>\n                  <jats:p>Journal of Endocrinology (1992) 134, 183\u2013195<\/jats:p>","DOI":"10.1677\/joe.0.1340183","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T18:11:46Z","timestamp":1229019106000},"page":"183-195","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":33,"title":["Metabolism of dihydrotestosterone to 3\u03b1-androstanediol in brain and plasma: effect on behavioural activity in female rats"],"prefix":"10.1530","volume":"134","author":[{"given":"M. S.","family":"Erskine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hippensteil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kornberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/134\/2\/joe_134_2_005.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/134\/2\/183\/101359\/joe_134_2_005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/134\/2\/183\/101359\/joe_134_2_005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:29:06Z","timestamp":1783607346000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/134\/2\/183\/17428\/Metabolism-of-dihydrotestosterone-to-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,8,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.1340183","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1992,8,1]]}}}