{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:12:04Z","timestamp":1791396724503,"version":"4.3.3"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It has been suggested that recombinant human IGF-I (rhIGF-I) is a potential therapeutic agent in diabetes mellitus. It is known to have glucose-lowering effects in normal individuals, in patients with non-insulindependent diabetes (NIDDM) and in extreme insulin-resistant states. IGF-binding proteins (IGFBPs) have the potential to affect the biological activity of rhIGF-I. We have studied the effect of infused rhIGF-I on IGFBP-1 and IGFBP-3 in a patient with Mendenhall's syndrome, a rare insulin-resistant state. During an infusion of 20 mg rhIGF-I, glucose concentrations fell from 44\u00b71 \u00b17\u00b72 to 31\u00b75 \u00b17\u00b72 (s.e.m.) mmol\/l (P=0\u00b7001), and insulin and C-peptide levels fell from 920 \u00b162 to 542\u00b145 mU\/l (P=0\u00b7008) and 5466 \u00b1633 to 3071 \u00b1297 pmol\/l (P= 0\u00b702) respectively. Significant lowering of phosphate, magnesium and alkaline phosphatase concentrations was also noted. IGF-I levels rose from 48 \u00b110\u00b72 to 410 \u00b150\u00b71 \u03bcg\/l (P=0\u00b7001), and those of IGF-II fell from 279\u00b78\u00b1 8\u00b73 to 104\u00b73 \u00b17\u00b79 \u03bcg\/l (P=0\u00b7001). IGFBP-1 concentrations did not significantly change during the infusion but those of IGFBP-3 increased from 1655 \u00b1 127 to 2197 \u00b1 334 \u03bcg\/l (P=0\u00b7002), despite a significant fall in GH concentrations from 10\u00b77\u00b12\u00b76 to 4\u00b71\u00b11\u00b71 mU\/l (P= 0\u00b7007), suggesting that IGFBP-3 regulation is also IGF-I-dependent. The lack of response of IGFBP-1 to a significant fall in insulin levels suggests that impaired insulin receptor function alters the usual regulation of IGFBP-1 by insulin. These findings are of importance, given the potential use of rhIGF-I in NIDDM.<\/jats:p>\n                  <jats:p>Journal of Endocrinology (1994) 141, 177\u2013182<\/jats:p>","DOI":"10.1677\/joe.0.1410177","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T18:11:46Z","timestamp":1229019106000},"page":"177-182","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":15,"title":["Response of insulin-like growth factor (IGF)-binding protein-1 (IGFBP-1) and IGFBP-3 to IGF-I treatment in severe insulin resistance"],"prefix":"10.1530","volume":"141","author":[{"given":"J D","family":"Quin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Checkley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A C","family":"MacCuish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J P","family":"Miell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/141\/1\/joe_141_1_020.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/141\/1\/177\/102926\/joe_141_1_020.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/141\/1\/177\/102926\/joe_141_1_020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:38:03Z","timestamp":1783514283000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/141\/1\/177\/17939\/Response-of-insulin-like-growth-factor-IGF-binding"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,4,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.1410177","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1994,4,1]]}}}