{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:21:46Z","timestamp":1787023306256,"version":"build-2736575974"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Under the guise of a satellite meeting of the 12th International Congress of Nephrology, Felix Frey (Bern) and John Funder (Melbourne) recently put together a comprehensive meeting in the secluded resort of Appenberg, Switzerland, devoted to the topic of 11 \u03b2-hydroxysteroid dehydrogenase (11\u03b2-HSD). Every international group working in this area was represented, with presentations and lively discussion from both clinicians and basic scientists in the field.<\/jats:p>\n                  <jats:p>With the recent characterization and cloning of 5\u03b1-reductases, 5\u2032deiodinase, and 3\u03b2\/17\u03b2-hydroxysteroid dehydrogenases, emphasis on steroid and thyroid hormone action is moving from abnormalities of secretion to studying tissue metabolism. This is particularly relevant for 11\u03b2-HSD and mineralocorticoid\/glucocorticoid hormone action. 11\u03b2-HSD is responsible for the interconversion of 'active' C11-hydroxylated C21-corticosteroids to their 'inactive' C11-keto derivatives. Although 11\u03b2-HSD activity had been described in liver, placenta and kidney in the 1950s, it was not until Drs Ulick and New ascribed a<\/jats:p>","DOI":"10.1677\/joe.0.1410191","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T18:11:46Z","timestamp":1229019106000},"page":"191-193","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":4,"title":["Lessons from Appenberg: 11\u03b2-hydroxysteroid dehydrogenase 1B or 2?"],"prefix":"10.1530","volume":"141","author":[{"given":"P M","family":"Stewart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Krozowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/141\/2\/joe_141_2_001.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/141\/2\/191\/102755\/joe_141_2_001.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/141\/2\/191\/102755\/joe_141_2_001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:36:26Z","timestamp":1783514186000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/141\/2\/191\/17891\/Lessons-from-Appenberg-11-hydroxysteroid"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,5,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,5,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.1410191","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1994,5,1]]}}}