{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:15:31Z","timestamp":1783520131794,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Since adrenal steroids have been shown to upregulate the concentration of Na+\u2013K+-ATPase in cardiac muscle, similar effects could be expected in skeletal muscle. Following infusion of dexamethasone (0\u00b702\u20130\u00b71 mg\/kg per day) for 7 days in 10-week-old rats, the total concentration of [3H]ouabain-binding sites rose by up to 22\u201342% in soleus, extensor digitorum longus, gastrocnemius and diaphragm muscle. Dexamethasone produced no or minute changes in the Na+\u2013K+ contents of skeletal muscle. In contrast, infusion with aldosterone (0\u00b702\u20130\u00b75 mg\/kg per day) for 7 days produced hypokalemia and a graded reduction in the K+ content of skeletal muscle, which was closely correlated to a downregulation of the [3 H]ouabain-binding site concentration (r= 0\u00b765\u20130\u00b770; P&amp;lt;0\u00b7001). The results indicate that in skeletal muscle high doses of glucocorticoids upregulate the concentration of Na+\u2013K+ pumps whereas mineralocorticoids induce a downregulation, which is secondary to the concomitant K+ deficiency. Since adrenalectomy produced no significant change in [3 H]ouabain-binding site concentration, basal levels of endogenous adrenal steroids seem to be of minor importance for the regulation of Na+\u2013K+ pump concentration in skeletal muscle.<\/jats:p>\n                  <jats:p>Journal of Endocrinology (1997) 152, 49\u201357<\/jats:p>","DOI":"10.1677\/joe.0.1520049","type":"journal-article","created":{"date-parts":[[2004,12,2]],"date-time":"2004-12-02T18:42:13Z","timestamp":1102012933000},"page":"49-57","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":26,"title":["Effects of adrenal steroids on the concentration of Na+\u2013K+ pumps in rat skeletal muscle"],"prefix":"10.1530","volume":"152","author":[{"given":"I","family":"D\u00f8rup","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Clausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/152\/1\/joe_152_1_007.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/152\/1\/49\/105502\/joe_152_1_007.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/152\/1\/49\/105502\/joe_152_1_007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:17:32Z","timestamp":1783516652000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/152\/1\/49\/18810\/Effects-of-adrenal-steroids-on-the-concentration"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.1520049","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1997,1,1]]}}}