{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:19:27Z","timestamp":1784557167269,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>\n                    The influence of secondary hyperparathyroidism (2 HPT) on the set point of the parathyroid hormone (PTH)-Ca\n                    <jats:sup>2+<\/jats:sup>\n                    curve is controversial.\n                    <jats:italic>In vitro<\/jats:italic>\n                    experiments have shown an increase in the set point. However, clinical studies with hemodialysis patients have provided a variety of results (increases, decreases and no changes in the set point have been reported). The present study was designed to investigate the influence of the progression of 2 HPT on the set point of the PTH-Ca\n                    <jats:sup>2+<\/jats:sup>\n                    curve. The PTH-Ca\n                    <jats:sup>2+<\/jats:sup>\n                    curve and the expression of parathyroid calcium receptor (CaR mRNA) and vitamin D receptor (VDR mRNA) have been studied in normal rabbits (group I,\n                    <jats:italic>n<\/jats:italic>\n                    =9) and in nephrectomized rabbits (group II,\n                    <jats:italic>n<\/jats:italic>\n                    =18) at two stages after inducing 2 HPT: 2\u20133 weeks (group IIA) and 5\u20136 weeks (group IIB). In group I, the set point of the PTH-Ca\n                    <jats:sup>2+<\/jats:sup>\n                    curve was 1.63\u00b10.03 mM. A progressive hypocalcemia was detected during the evolution of 2 HPT (groups IIA and IIB). Rabbits from group IIA had a significant (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001) decrease in the set point to values of 1.45\u00b10.02 mM. However, the set point increased significantly in group IIB (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001) to 1.56\u00b10.03 mM. CaR mRNA was similarly decreased in groups IIA (39\u00b112%) and IIB (48\u00b17%). No changes were detected in VDR mRNA. In conclusion, a reduction in the set point of the PTH-Ca\n                    <jats:sup>2+<\/jats:sup>\n                    curve in response to decreased extracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    was detected in the early phases of 2 HPT. However, with the progression of 2 HPT the set point tended to increase even though extracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    was markedly decreased. The increase in the set point in the course of 2 HPT seems to be a complex process that cannot be fully explained by changes in parathyroid CaR mRNA or VDR mRNA.\n                  <\/jats:p>","DOI":"10.1677\/joe.1.05565","type":"journal-article","created":{"date-parts":[[2005,1,21]],"date-time":"2005-01-21T16:17:56Z","timestamp":1106324276000},"page":"241-247","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":15,"title":["The influence of the progression of secondary hyperparathyroidism on the set point of the parathyroid hormone-calcium curve"],"prefix":"10.1530","volume":"184","author":[{"given":"S","family":"Bas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Aguilera-Tejero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"Estepa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Maduen\u0303o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/184\/1\/1840241.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/184\/1\/1840241.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:55:21Z","timestamp":1784555721000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/184\/1\/241-247\/20883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1677\/joe.1.05565","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}