{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:20:43Z","timestamp":1784557243430,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>\n                    Profound changes in thyroid hormone metabolism occur in the central part of the hypothalamus\u2013pituitary\u2013thyroid (HPT) axis during fasting. Hypothalamic changes are partly reversed by leptin administration, which decreases during fasting. It is unknown to what extent leptin affects the HPT axis at the level of the pituitary. We, therefore, studied fasting-induced alterations in pituitary thyroid hormone metabolism, as well as effects of leptin administration on these changes. Because refeeding rapidly increased serum leptin, the same parameters were studied after fasting followed by refeeding. Fasting for 24 h decreased serum T\n                    <jats:sub>3<\/jats:sub>\n                    and T\n                    <jats:sub>4<\/jats:sub>\n                    and pituitary TSH\u03b2, type 2deiodinase (D2), and thyroid hormone receptor \u03b22 (TR\u03b22) mRNA expression. The decrease in D2 and TR\u03b22 mRNA expression was prevented when 20 \u03bcg leptin was administered twice during fasting. By contrast, the decrease in TSH\u03b2 mRNA expression was unaffected. A single dose of leptin given after 24 h fasting did not affect decreased TSH\u03b2, D2, and TR\u03b22 mRNA expression, while 4 h refeeding resulted in pituitary D2 and TR\u03b22 mRNA expression as observed in control mice. Serum leptin, T\n                    <jats:sub>3<\/jats:sub>\n                    , and T\n                    <jats:sub>4<\/jats:sub>\n                    after refeeding were similar compared with leptin administration. We conclude that fasting decreases pituitary TSH\u03b2, D2, and TR\u03b22 mRNA expression, which (with the exception of TSH\u03b2) can be prevented by leptin administration during fasting. Following 24 h fasting, 4 h refeeding completely restores pituitary D2 and TR\u03b22 mRNA expression, while a single leptin dose is ineffective. This indicates that other postingestion signals may be necessary to modulate rapidly the fasting-induced decrease in pituitary D2 and TR\u03b22 mRNA expression.\n                  <\/jats:p>","DOI":"10.1677\/joe.1.06872","type":"journal-article","created":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T13:02:07Z","timestamp":1155128527000},"page":"537-544","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":32,"title":["Differential effects of leptin and refeeding on the fasting-induced decrease of pituitary type 2 deiodinase and thyroid hormone receptor \u03b22 mRNA expression in mice"],"prefix":"10.1530","volume":"190","author":[{"given":"A","family":"Boelen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kwakkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X G","family":"Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W M","family":"Wiersinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Fliers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/190\/2\/1900537.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/190\/2\/1900537.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:56:43Z","timestamp":1784555803000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/190\/2\/537-544\/21168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1677\/joe.1.06872","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}