{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:05:44Z","timestamp":1778058344713,"version":"3.51.4"},"reference-count":25,"publisher":"Emerald","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinspired, Biomimetic and Nanobiomaterials"],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:p> Biological requirements call for substantial porosities in clinical biomaterials \u2013 challenging the mechanical integrity and strength of the latter. In this study, the authors resort to quantitative engineering principles to assess the fracture safety of double-porous hydroxyapatite ceramics: micro-computed tomography scans give access to the morphology of macropores at the submillimeter scale, as well as to voxel-specific microporosities. Advanced micromechanics of porous ceramics with needle-shaped elementary units then allows for translating voxel-specific microporosities to corresponding elasticity and strength properties, as well as to macro-to-micro scale transition (\u2018concentration\u2019) tensors. These mechanical properties and tensors are fed into a large-scale finite-element model of a biomaterial granule as used for mandibular tissue regeneration. Loading the granule in splitting mode, up to physiological strain, evidences stress concentrations at the loaded poles and close to internal macropores and cracks. A parallel computing-supported subvoxel analysis of needle orientations evidences that in highly loaded regions, the intravoxel \u2018single crystals\u2019 oriented perpendicular to the loading direction undergo the most unfavorable loading. Still, only 0\u00b76% of the finite-elements show stresses indicating failure, and the mean safety factor against fracture is as high as 7. This analysis confirms, from an engineering science viewpoint, the successful use of the investigated biomaterials in clinical practice. <\/jats:p>","DOI":"10.1680\/jbibn.15.00021","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T10:45:52Z","timestamp":1453373152000},"page":"24-36","source":"Crossref","is-referenced-by-count":10,"title":["Fracture safety of double-porous hydroxyapatite                biomaterials"],"prefix":"10.1680","volume":"5","author":[{"given":"Alexander","family":"Dejaco","sequence":"first","affiliation":[{"name":"Institute for Mechanics of Materials and Structures, TU Wien \u2013 Vienna                   University of Technology, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir S.","family":"Komlev","sequence":"additional","affiliation":[{"name":"A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of                   Sciences, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Jaroszewicz","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Warsaw University of                   Technology, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Swieszkowski","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Warsaw University of                   Technology, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Hellmich","sequence":"additional","affiliation":[{"name":"Institute for Mechanics of Materials and Structures, TU Wien \u2013 Vienna                   University of Technology, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"140","reference":[{"key":"jbibn-v5i1p24r1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014015002331"},{"key":"jbibn-v5i1p24r2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00049-2"},{"key":"jbibn-v5i1p24r3","doi-asserted-by":"publisher","DOI":"10.1016\/j.stam.2003.11.007"},{"key":"jbibn-v5i1p24r4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2011.12.026"},{"key":"jbibn-v5i1p24r5","doi-asserted-by":"publisher","DOI":"10.1061\/(ASCE)0733-9399(2009)135:5(395)"},{"key":"jbibn-v5i1p24r6","author":"Fritsch A","year":"2013","journal-title":"Journal of Applied Mechanics"},{"key":"jbibn-v5i1p24r7","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31727"},{"key":"jbibn-v5i1p24r8","doi-asserted-by":"publisher","DOI":"10.1061\/(ASCE)EM.1943-7889.0000072"},{"key":"jbibn-v5i1p24r9","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-7949(01)00057-8"},{"key":"jbibn-v5i1p24r10","doi-asserted-by":"publisher","DOI":"10.1061\/(ASCE)GT.1943-5606.0000791"},{"key":"jbibn-v5i1p24r11","doi-asserted-by":"publisher","DOI":"10.1061\/(ASCE)0733-9399(2002)128:8(808)"},{"key":"jbibn-v5i1p24r12","doi-asserted-by":"publisher","DOI":"10.1002\/0470032006"},{"key":"jbibn-v5i1p24r13","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(71)90007-8"},{"key":"jbibn-v5i1p24r14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00543533"},{"key":"jbibn-v5i1p24r16","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007539929374"},{"key":"jbibn-v5i1p24r17","doi-asserted-by":"publisher","DOI":"10.1145\/42288.42291"},{"key":"jbibn-v5i1p24r19","doi-asserted-by":"publisher","DOI":"10.1109\/SC.1998.10004"},{"key":"jbibn-v5i1p24r20","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8191(00)00087-9"},{"key":"jbibn-v5i1p24r21","doi-asserted-by":"publisher","DOI":"10.1145\/77626.79170"},{"key":"jbibn-v5i1p24r22","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-739X(03)00170-5"},{"key":"jbibn-v5i1p24r25","doi-asserted-by":"publisher","DOI":"10.1061\/(ASCE)EM.1943-7889.0000002"},{"key":"jbibn-v5i1p24r26","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.10.072"},{"key":"jbibn-v5i1p24r27","doi-asserted-by":"publisher","DOI":"10.1038\/nmat1911"},{"key":"jbibn-v5i1p24r28","doi-asserted-by":"publisher","DOI":"10.1007\/s11548-012-0739-9"},{"key":"jbibn-v5i1p24r29","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.06.009"}],"container-title":["Bioinspired, Biomimetic and Nanobiomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.icevirtuallibrary.com\/doi\/pdf\/10.1680\/jbibn.15.00021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T20:57:45Z","timestamp":1753390665000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.emerald.com\/jbibn\/article\/5\/1\/24-36\/394152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,3,1]]}},"alternative-id":["10.1680\/jbibn.15.00021"],"URL":"https:\/\/doi.org\/10.1680\/jbibn.15.00021","relation":{},"ISSN":["2045-9858","2045-9866"],"issn-type":[{"value":"2045-9858","type":"print"},{"value":"2045-9866","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,1]]}}}