{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:17:58Z","timestamp":1775243878226,"version":"3.50.1"},"reference-count":28,"publisher":"Emerald","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,3]]},"abstract":"<jats:p>Current strategies for bone reconstruction are quite limited, falling short in effectively fostering tissue regeneration. Within tissue engineering, a primary objective has been the creation of scaffolds \u2013 porous, bioactive, and biocompatible three-dimensional (3-D) structures mimicking the extracellular matrix. This article focuses on crafting and characterizing scaffolds capable of replicating the bone\u2019s extracellular matrix through a silicate coating. The goal is to bolster mechanical strength and encourage cell osteogenesis and osteoconduction. Using polycaprolactone\/chitosan blends, nanofibrous membranes were electrospun and transformed into 3-D structures through \u2018Thermally-Induced Self-Agglomeration\u2019. Specifically, scaffolds with 10% chitosan content were created and compared with pure polycaprolactone (PCL) variants. Infrared spectroscopy and thermal assessment confirmed the compatibility of PCL and chitosan, emphasizing the scaffolds\u2019 resilience to high temperatures. Scanning electron microscopy images showcased an interconnected network of nano- and micropores with porosity exceeding 99%, mimicking trabecular bone. Wettability and swelling studies revealed a substantial water intake capacity with a significant increase in hydrophilicity after coating with silicon dioxide. These comprehensive studies suggest that the scaffolds indeed fulfill the necessary requirements for their application in tissue engineering.<\/jats:p>","DOI":"10.1680\/jbibn.24.00020","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T12:41:58Z","timestamp":1772887318000},"page":"34-47","source":"Crossref","is-referenced-by-count":1,"title":["Silicate coating of electrospun polycaprolactone\/chitosan nanofibrous scaffolds for tissue engineering"],"prefix":"10.1680","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6068-4385","authenticated-orcid":true,"given":"Duaete Rafael","family":"Salgado de Almeida","sequence":"first","affiliation":[{"name":"University of Aveiro TEMA Centre for Mechanical Technology and Automation, Department of Mechanical Engineering, , Aveiro,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3910-4993","authenticated-orcid":true,"given":"Andr\u00e9","family":"Lopes","sequence":"additional","affiliation":[{"name":"University of Aveiro CICECO Aveiro Institute of Materials, Department of Materials and Ceramic Engineering, , Aveiro,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1240-2512","authenticated-orcid":true,"given":"Maria Helena V.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"University of Aveiro CICECO Aveiro Institute of Materials, Department of Materials and Ceramic Engineering, , Aveiro,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7439-209X","authenticated-orcid":true,"given":"Samuel","family":"Guieu","sequence":"additional","affiliation":[{"name":"University of Aveiro CICECO Aveiro Institute of Materials, LAQV-REQUIMTE, Department of Chemistry, , Aveiro,","place":["Portugal"]}]}],"member":"140","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"issue":"(8)","key":"2026040302572750300_ref001","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/s41578-020-0204-2","article-title":"Materials design for bone-tissue engineering","volume":"5","author":"Koons","year":"2020","journal-title":"Nature Reviews Materials"},{"issue":"(4)","key":"2026040302572750300_ref002","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/BOT.0000000000001420","article-title":"Autograft, allograft, and bone graft substitutes: clinical evidence and indications for use in the setting of orthopaedic trauma surgery","volume":"33","author":"Baldwin","year":"2019","journal-title":"Journal of Orthopaedic Trauma"},{"key":"2026040302572750300_ref003","doi-asserted-by":"publisher","first-page":"100248","DOI":"10.1016\/j.cobme.2020.100248","article-title":"Bone tissue engineering techniques, advances, and scaffolds for treatment of bone defects","volume":"17","author":"Alonzo","year":"2021","journal-title":"Current Opinion in Biomedical Engineering"},{"key":"2026040302572750300_ref004","doi-asserted-by":"publisher","first-page":"617141","DOI":"10.3389\/fbioe.2021.617141","article-title":"Design challenges in polymeric scaffolds for tissue engineering","volume":"9","author":"Echeverria Molina","year":"2021","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"issue":"(15)","key":"2026040302572750300_ref005","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1002\/adhm.201500345","article-title":"Electrospun polycaprolactone 3D nanofibrous scaffold with interconnected and hierarchically structured pores for bone tissue engineering","volume":"4","author":"Xu","year":"2015","journal-title":"Advanced Healthcare Materials"},{"issue":"(1)","key":"2026040302572750300_ref006","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3390\/polym14010182","article-title":"Natural fiber-reinforced polycaprolactone green and hybrid biocomposites for various advanced applications","volume":"14","author":"Ilyas","year":"2022","journal-title":"Polymers"},{"issue":"(7)","key":"2026040302572750300_ref007","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1002\/jbm.a.37480","article-title":"Three-dimensional nanofibrous and porous scaffolds of poly(\u03b5-caprolactone)-chitosan blends for musculoskeletal tissue engineering","volume":"111","author":"Pereira","year":"2023","journal-title":"Journal of Biomedical Materials Research. 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