{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:39:30Z","timestamp":1790771970895,"version":"4.1.0"},"reference-count":104,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>\n                      AKI is a major clinical complication leading to high mortality, but intensive research over the past decades has not led to targeted preventive or therapeutic measures. In rodent models, caloric restriction (CR) and transient hypoxia significantly prevent AKI and a recent comparative transcriptome analysis of murine kidneys identified kynureninase (KYNU) as a shared downstream target. The present work shows that KYNU strongly contributes to CR-mediated protection as a key player in the\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      nicotinamide adenine dinucleotide biosynthesis pathway. Importantly, the link between CR and NAD+ biosynthesis could be recapitulated in a human cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical practice lacks strategies to treat AKI. Interestingly, preconditioning by hypoxia and caloric restriction (CR) is highly protective in rodent AKI models. However, the underlying molecular mechanisms of this process are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Kynureninase (KYNU) knockout mice were generated by Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and comparative transcriptome, proteome and metabolite analyses of murine kidneys pre- and post-ischemia-reperfusion injury in the context of CR or ad libitum diet were performed. In addition, acetyl-lysin enrichment and mass spectrometry were used to assess protein acetylation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified KYNU as a downstream target of CR and show that KYNU strongly contributes to the protective effect of CR. The KYNU-dependent\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      nicotinamide adenine dinucleotide (NAD+) biosynthesis pathway is necessary for CR-associated maintenance of NAD+ levels. This finding is associated with reduced protein acetylation in CR-treated animals, specifically affecting enzymes in energy metabolism. Importantly, the effect of CR on\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      NAD+ biosynthesis pathway metabolites can be recapitulated in humans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      CR induces the\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      NAD+ synthesis pathway in the context of IRI and is essential for its full nephroprotective potential. Differential protein acetylation may be the molecular mechanism underlying the relationship of NAD+, CR, and nephroprotection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.0000000000000087","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T15:08:35Z","timestamp":1675955315000},"page":"772-792","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":27,"title":["Organ Protection by Caloric Restriction Depends on Activation of the De Novo NAD+ Synthesis Pathway"],"prefix":"10.1681","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1624-0055","authenticated-orcid":false,"given":"Martin R.","family":"Sp\u00e4th","sequence":"first","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3357-2289","authenticated-orcid":false,"given":"K. Johanna R.","family":"Hoyer-Allo","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3931-6152","authenticated-orcid":false,"given":"Lisa","family":"Seufert","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8698-5389","authenticated-orcid":false,"given":"Martin","family":"H\u00f6hne","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6575-3877","authenticated-orcid":false,"given":"Christina","family":"Lucas","sequence":"additional","affiliation":[{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Bock","sequence":"additional","affiliation":[{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"Institute of Genetics, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-3999","authenticated-orcid":false,"given":"Lea","family":"Isermann","sequence":"additional","affiliation":[{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"Medical Faculty, Institute for Mitochondrial Diseases and Aging, University of Cologne, Cologne, Germany"},{"name":"Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5631-0663","authenticated-orcid":false,"given":"Susanne","family":"Brodesser","sequence":"additional","affiliation":[{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8182-8034","authenticated-orcid":false,"given":"Jan-Wilm","family":"Lackmann","sequence":"additional","affiliation":[{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3812-217X","authenticated-orcid":false,"given":"Katharina","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9269-7420","authenticated-orcid":false,"given":"Felix C.","family":"Koehler","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Bohl","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6057-7694","authenticated-orcid":false,"given":"Michael","family":"Ignarski","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9957-1465","authenticated-orcid":false,"given":"Petra","family":"Schiller","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0326-0778","authenticated-orcid":false,"given":"Marc","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Kubacki","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5766-7477","authenticated-orcid":false,"given":"Franziska","family":"Grundmann","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Benzing","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Trifunovic","sequence":"additional","affiliation":[{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"Medical Faculty, Institute for Mitochondrial Diseases and Aging, University of Cologne, Cologne, Germany"},{"name":"Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"Institute of Genetics, University of Cologne, Cologne, Germany"},{"name":"Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Schermer","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Burst","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"Emergency Department, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6910-0745","authenticated-orcid":false,"given":"Roman-Ulrich","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"CECAD, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"issue":"4","key":"B1-20250823","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrneph.2013.282","article-title":"Acute kidney injury\u2014epidemiology, outcomes and economics","volume":"10","author":"Rewa","year":"2014","journal-title":"Nat Rev Nephrol."},{"issue":"2","key":"B2-20250823","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/sj.ki.5002297","article-title":"Community-based incidence of acute renal failure","volume":"72","author":"Hsu","year":"2007","journal-title":"Kidney Int."},{"issue":"11","key":"B3-20250823","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1001\/jama.2009.1322","article-title":"Chronic dialysis and death among survivors of acute kidney injury requiring dialysis","volume":"302","author":"Wald","year":"2009","journal-title":"JAMA."},{"issue":"11","key":"B4-20250823","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.2215\/CJN.01120211","article-title":"Acute kidney injury episodes and chronic kidney disease risk in diabetes mellitus","volume":"6","author":"Thakar","year":"2011","journal-title":"Clin J Am Soc Nephrol."},{"issue":"2","key":"B5-20250823","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1681\/ASN.2009060636","article-title":"Acute kidney injury associates with increased long-term mortality","volume":"21","author":"Lafrance","year":"2010","journal-title":"J Am Soc Nephrol."},{"issue":"1083","key":"B6-20250823","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/postgradmedj-2015-133496","article-title":"Improving outcomes in patients with Acute Kidney Injury: the impact of hospital based automated AKI alerts","volume":"92","author":"Prendecki","year":"2016","journal-title":"Postgrad Med J."},{"issue":"11","key":"B7-20250823","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1681\/ASN.2004090740","article-title":"Acute kidney injury, mortality, length of stay, and costs in hospitalized patients","volume":"16","author":"Chertow","year":"2005","journal-title":"J Am Soc Nephrol."},{"issue":"6","key":"B8-20250823","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1053\/j.ajkd.2008.11.034","article-title":"Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis","volume":"53","author":"Coca","year":"2009","journal-title":"Am J Kidney Dis."},{"issue":"4","key":"B9-20250823","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrneph.2017.184","article-title":"Paradigms of acute kidney injury in the intensive care setting","volume":"14","author":"Kellum","year":"2018","journal-title":"Nat Rev Nephrol."},{"issue":"10","key":"B10-20250823","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41581-019-0184-x","article-title":"Molecular nephrology: types of acute tubular injury","volume":"15","author":"Desanti De Oliveira","year":"2019","journal-title":"Nat Rev Nephrol."},{"issue":"4","key":"B11-20250823","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00134-015-4157-7","article-title":"Incidence and associations of acute kidney injury after major abdominal surgery","volume":"42","author":"O'Connor","year":"2016","journal-title":"Intensive Care Med."},{"issue":"5","key":"B12-20250823","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41581-021-00394-7","article-title":"Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection","volume":"17","author":"Scholz","year":"2021","journal-title":"Nat Rev Nephrol."},{"issue":"2","key":"B13-20250823","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/08860229909066978","article-title":"Laboratory study: ischemic preconditioning attenuates functional, metabolic, and morphologic injury from ischemic acute renal failure in the rat","volume":"21","author":"Cochrane","year":"1999","journal-title":"Ren Fail."},{"issue":"1","key":"B14-20250823","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1474-9726.2009.00532.x","article-title":"Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice","volume":"9","author":"Mitchell","year":"2010","journal-title":"Aging Cell."},{"issue":"7","key":"B15-20250823","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1681\/ASN.2005121302","article-title":"Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure","volume":"17","author":"Bernhardt","year":"2006","journal-title":"J Am Soc Nephrol."},{"issue":"11","key":"B16-20250823","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1097\/TP.0b013e3181bb4a07","article-title":"Repetitive hypoxic preconditioning attenuates renal ischemia\/reperfusion induced oxidative injury via upregulating HIF-1 alpha-dependent bcl-2 signaling","volume":"88","author":"Yang","year":"2009","journal-title":"Transplantation."},{"issue":"7415","key":"B17-20250823","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nature11432","article-title":"Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study","volume":"489","author":"Mattison","year":"2012","journal-title":"Nature."},{"issue":"4","key":"B18-20250823","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1681\/ASN.2019050534","article-title":"The integrated RNA landscape of renal preconditioning against ischemia- reperfusion injury","volume":"31","author":"Johnsen","year":"2020","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"B19-20250823","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.kint.2018.08.037","article-title":"The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury","volume":"95","author":"Sp\u00e4th","year":"2019","journal-title":"Kidney Int."},{"issue":"7","key":"B20-20250823","doi-asserted-by":"crossref","first-page":"109547","DOI":"10.1016\/j.celrep.2021.109547","article-title":"Hypoxic preconditioning protects against ischemic kidney injury through the Ido1\/kynurenine pathway","volume":"36","author":"Torosyan","year":"2021","journal-title":"Cell Rep."},{"issue":"2","key":"B21-20250823","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41581-019-0216-6","article-title":"NAD(+) homeostasis in renal health and disease","volume":"16","author":"Ralto","year":"2019","journal-title":"Nat Rev Nephrol."},{"issue":"5","key":"B22-20250823","doi-asserted-by":"crossref","first-page":"e0196891","DOI":"10.1371\/journal.pone.0196891","article-title":"An optimized electroporation approach for efficient CRISPR\/Cas9 genome editing in murine zygotes","volume":"13","author":"Tr\u00f6der","year":"2018","journal-title":"PLoS One."},{"issue":"1","key":"B23-20250823","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12896-016-0234-4","article-title":"Efficient generation of Rosa26 knock-in mice using CRISPR\/Cas9 in C57BL\/6 zygotes","volume":"16","author":"Chu","year":"2016","journal-title":"BMC Biotechnol."},{"key":"B24-20250823","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ymeth.2017.02.008","article-title":"Gene editing in mouse zygotes using the CRISPR\/Cas9 system","volume":"121-122","author":"Wefers","year":"2017","journal-title":"Methods."},{"issue":"4","key":"B25-20250823","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/00004647-200204000-00003","article-title":"Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain","volume":"22","author":"Bernaudin","year":"2002","journal-title":"J Cereb Blood Flow Metab."},{"issue":"8","key":"B26-20250823","doi-asserted-by":"crossref","first-page":"e0161315","DOI":"10.1371\/journal.pone.0161315","article-title":"Oral supplementation of glucosamine fails to alleviate acute kidney injury in renal ischemia-reperfusion damage","volume":"11","author":"Johnsen","year":"2016","journal-title":"PLoS One."},{"issue":"10","key":"B27-20250823","doi-asserted-by":"crossref","first-page":"F1305","DOI":"10.1152\/ajprenal.00445.2011","article-title":"The hormone melatonin stimulates renoprotective effects of \u201cearly outgrowth\u201d endothelial progenitor cells in acute ischemic kidney injury","volume":"302","author":"Patschan","year":"2012","journal-title":"Am J Physiol Renal Physiol."},{"issue":"7","key":"B28-20250823","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods."},{"issue":"6","key":"B29-20250823","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1093\/hmg\/ddv638","article-title":"Three- layered proteomic characterization of a novel ACTN4 mutation unravels its pathogenic potential in FSGS","volume":"25","author":"Bartram","year":"2016","journal-title":"Hum Mol Genet."},{"issue":"3","key":"B30-20250823","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1021\/ac026117i","article-title":"Stop and go extraction tips for matrix-assisted laser desorption\/ionization, nanoelectrospray, and LC\/MS sample pretreatment in proteomics","volume":"75","author":"Rappsilber","year":"2003","journal-title":"Anal Chem."},{"issue":"7","key":"B31-20250823","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/hmg\/ddw016","article-title":"The ubiquitin ligase Ubr4 controls stability of podocin\/MEC-2 supercomplexes","volume":"25","author":"Rinschen","year":"2016","journal-title":"Hum Mol Genet."},{"issue":"8","key":"B32-20250823","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/j.celrep.2018.04.059","article-title":"A multi-layered quantitative in vivo expression atlas of the podocyte unravels kidney disease candidate genes","volume":"23","author":"Rinschen","year":"2018","journal-title":"Cell Rep."},{"issue":"7","key":"B33-20250823","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/bioinformatics\/btq054","article-title":"Skyline: an open source document editor for creating and analyzing targeted proteomics experiments","volume":"26","author":"MacLean","year":"2010","journal-title":"Bioinformatics."},{"issue":"6","key":"B34-20250823","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.kint.2017.12.012","article-title":"Single-nephron proteomes connect morphology and function in proteinuric kidney disease","volume":"93","author":"H\u00f6hne","year":"2018","journal-title":"Kidney Int."},{"issue":"8","key":"B35-20250823","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/nprot.2007.261","article-title":"Protocol for micro-purification, enrichment, pre- fractionation and storage of peptides for proteomics using StageTips","volume":"2","author":"Rappsilber","year":"2007","journal-title":"Nat Protoc."},{"issue":"12","key":"B36-20250823","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.- range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat Biotechnol."},{"issue":"4","key":"B37-20250823","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1021\/pr101065j","article-title":"Andromeda: a peptide search engine integrated into the MaxQuant environment","volume":"10","author":"Cox","year":"2011","journal-title":"J Proteome Res."},{"issue":"1","key":"B38-20250823","doi-asserted-by":"crossref","first-page":"12648","DOI":"10.1038\/s41598-018-31154-6","article-title":"Instant Clue: a software suite for interactive data visualization and analysis","volume":"8","author":"Nolte","year":"2018","journal-title":"Sci Rep."},{"issue":"18","key":"B39-20250823","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.4155\/bio-2016-0111","article-title":"LC-MS\/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain","volume":"8","author":"Fuertig","year":"2016","journal-title":"Bioanalysis."},{"issue":"5","key":"B40-20250823","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.cmet.2018.03.018","article-title":"Quantitative analysis of NAD synthesis-breakdown fluxes","volume":"27","author":"Liu","year":"2018","journal-title":"Cell Metab."},{"key":"B41-20250823","doi-asserted-by":"crossref","first-page":"113252","DOI":"10.1016\/j.expneurol.2020.113252","article-title":"cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons","volume":"329","author":"Sasaki","year":"2020","journal-title":"Exp Neurol."},{"issue":"1","key":"B42-20250823","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1038\/s41598-020-61895-2","article-title":"Dietary restriction for prevention of contrast-induced acute kidney injury in patients undergoing percutaneous coronary angiography: a randomized controlled trial","volume":"10","author":"Grundmann","year":"2020","journal-title":"Sci Rep."},{"issue":"D1","key":"B43-20250823","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","article-title":"2016 update of the PRIDE database and its related tools","volume":"44","author":"Vizca\u00edno","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"6390","key":"B44-20250823","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1126\/science.aar2131","article-title":"Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease","volume":"360","author":"Park","year":"2018","journal-title":"Science."},{"issue":"1","key":"B45-20250823","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1681\/ASN.2018090912","article-title":"Advantages of single-nucleus over single- cell RNA sequencing of adult kidney: rare cell types and novel cell states revealed in fibrosis","volume":"30","author":"Wu","year":"2019","journal-title":"J Am Soc Nephrol."},{"issue":"11","key":"B46-20250823","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1681\/ASN.2014111067","article-title":"Deep sequencing in microdissected renal tubules identifies nephron segment-specific transcriptomes","volume":"26","author":"Lee","year":"2015","journal-title":"J Am Soc Nephrol."},{"issue":"6","key":"B47-20250823","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1681\/ASN.2020010071","article-title":"Quantitative proteomics of all 14 renal tubule segments in rat","volume":"31","author":"Limbutara","year":"2020","journal-title":"J Am Soc Nephrol."},{"issue":"6220","key":"B48-20250823","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science."},{"issue":"3","key":"B49-20250823","doi-asserted-by":"crossref","first-page":"F565","DOI":"10.1152\/ajprenal.2000.279.3.F565","article-title":"Mechanism of increases in l-kynurenine and quinolinic acid in renal insufficiency","volume":"279","author":"Saito","year":"2000","journal-title":"Am J Physiol Renal Physiol."},{"issue":"6","key":"B50-20250823","doi-asserted-by":"crossref","first-page":"e008181","DOI":"10.1161\/JAHA.117.008181","article-title":"Preoperative short-term calorie restriction for prevention of acute kidney injury after cardiac surgery: a randomized, controlled, open-label, pilot trial","volume":"7","author":"Grundmann","year":"2018","journal-title":"J Am Heart Assoc."},{"issue":"7595","key":"B51-20250823","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature17184","article-title":"PGC1\u03b1 drives NAD biosynthesis linking oxidative metabolism to renal protection","volume":"531","author":"Tran","year":"2016","journal-title":"Nature."},{"issue":"8","key":"B52-20250823","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1681\/ASN.2016040385","article-title":"Nicotinamide mononucleotide, an NAD(+) precursor, rescues age-associated susceptibility to AKI in a sirtuin 1-dependent manner","volume":"28","author":"Guan","year":"2017","journal-title":"J Am Soc Nephrol."},{"key":"B53-20250823","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.abb.2013.10.020","article-title":"Structure and mechanism of kynureninase","volume":"544","author":"Phillips","year":"2014","journal-title":"Arch Biochem Biophys."},{"issue":"11","key":"B54-20250823","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1016\/j.bbagen.2016.07.002","article-title":"Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice","volume":"1860","author":"Larkin","year":"2016","journal-title":"Biochim Biophys Acta."},{"key":"B55-20250823","doi-asserted-by":"crossref","first-page":"110841","DOI":"10.1016\/j.exger.2020.110841","article-title":"Kynurenine pathway, NAD(+) synthesis, and mitochondrial function: targeting tryptophan metabolism to promote longevity and healthspan","volume":"132","author":"Castro-Portuguez","year":"2020","journal-title":"Exp Gerontol."},{"issue":"2","key":"B56-20250823","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0210-x","article-title":"Kynurenine 3-monooxygenase is a critical regulator of renal ischemia-reperfusion injury","volume":"51","author":"Zheng","year":"2019","journal-title":"Exp Mol Med."},{"issue":"6","key":"B57-20250823","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1016\/j.jaci.2015.09.055","article-title":"The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases","volume":"137","author":"Harden","year":"2016","journal-title":"J Allergy Clin Immunol."},{"issue":"10","key":"B58-20250823","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1083\/jcb.201802144","article-title":"Myoepithelial cells are a dynamic barrier to epithelial dissemination","volume":"217","author":"Sirka","year":"2018","journal-title":"J Cell Biol."},{"issue":"10","key":"B59-20250823","doi-asserted-by":"crossref","first-page":"6700","DOI":"10.1111\/jcmm.14547","article-title":"A novel role of kynureninase in the growth control of breast cancer cells and its relationships with breast cancer","volume":"23","author":"Liu","year":"2019","journal-title":"J Cell Mol Med."},{"issue":"2","key":"B60-20250823","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/ced.14072","article-title":"Downregulation of kynureninase restrains cutaneous squamous cell carcinoma proliferation and represses the PI3K\/AKT pathway","volume":"45","author":"Ci","year":"2020","journal-title":"Clin Exp Dermatol."},{"issue":"4","key":"B61-20250823","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/acel.12595","article-title":"Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity","volume":"16","author":"Sutphin","year":"2017","journal-title":"Aging Cell."},{"issue":"6","key":"B62-20250823","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1056\/NEJMoa1616361","article-title":"NAD deficiency, congenital malformations, and niacin supplementation","volume":"377","author":"Shi","year":"2017","journal-title":"N Engl J Med."},{"issue":"9","key":"B63-20250823","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/s41591-018-0138-z","article-title":"De novo NAD(+) biosynthetic impairment in acute kidney injury in humans","volume":"24","author":"Poyan Mehr","year":"2018","journal-title":"Nat Med."},{"issue":"7731","key":"B64-20250823","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/s41586-018-0645-6","article-title":"De novo NAD+ synthesis enhances mitochondrial function and improves health","volume":"563","author":"Katsyuba","year":"2018","journal-title":"Nature."},{"issue":"2","key":"B65-20250823","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/abio.2002.5715","article-title":"LC\/MS analysis of NAD biosynthesis using stable isotope pyridine precursors","volume":"306","author":"Evans","year":"2002","journal-title":"Anal Biochem."},{"issue":"49","key":"B66-20250823","doi-asserted-by":"crossref","first-page":"50754","DOI":"10.1074\/jbc.M408388200","article-title":"The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells","volume":"279","author":"Revollo","year":"2004","journal-title":"J Biol Chem."},{"issue":"2","key":"B67-20250823","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cell.2016.03.037","article-title":"EGLN1 inhibition and rerouting of alpha-ketoglutarate suffice for remote ischemic protection","volume":"165","author":"Olenchock","year":"2016","journal-title":"Cell."},{"issue":"3","key":"B68-20250823","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.ajpath.2011.05.048","article-title":"The tryptophan metabolite 3- hydroxyanthranilic acid plays anti-inflammatory and neuroprotective roles during inflammation: role of hemeoxygenase-1","volume":"179","author":"Krause","year":"2011","journal-title":"Am J Pathol."},{"issue":"11","key":"B69-20250823","doi-asserted-by":"crossref","first-page":"e1005213","DOI":"10.1371\/journal.pcbi.1005213","article-title":"Antioxidant properties of kynurenines: density functional theory calculations","volume":"12","author":"Zhuravlev","year":"2016","journal-title":"PLoS Comput Biol."},{"issue":"5","key":"B70-20250823","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.molcel.2022.02.007","article-title":"Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling","volume":"82","author":"Fiore","year":"2022","journal-title":"Mol Cell."},{"issue":"6389","key":"B71-20250823","doi-asserted-by":"crossref","first-page":"eaan5780","DOI":"10.1126\/science.aan5780","article-title":"Metabolic regulation of transcription through compartmentalized NAD(+) biosynthesis","volume":"360","author":"Ryu","year":"2018","journal-title":"Science."},{"issue":"6","key":"B72-20250823","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/jnc.14878","article-title":"Subcellular NAMPT- mediated NAD(+) salvage pathways and their roles in bioenergetics and neuronal protection after ischemic injury","volume":"151","author":"Wang","year":"2019","journal-title":"J Neurochem."},{"issue":"10","key":"B73-20250823","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.tibs.2020.05.010","article-title":"Location, location, location: compartmentalization of NAD(+) synthesis and functions in mammalian cells","volume":"45","author":"Cambronne","year":"2020","journal-title":"Trends Biochem Sci."},{"issue":"3","key":"B74-20250823","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.mam.2011.07.001","article-title":"Caloric restriction","volume":"32","author":"Speakman","year":"2011","journal-title":"Mol Aspects Med."},{"key":"B75-20250823","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/978-1-0716-2788-4_18","article-title":"Assessment of mitochondrial dysfunctions after sirtuin inhibition","volume":"2589","author":"Marx","year":"2023","journal-title":"Methods Mol Biol."},{"issue":"7","key":"B76-20250823","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1681\/ASN.2017111218","article-title":"Sirtuins in renal health and disease","volume":"29","author":"Morigi","year":"2018","journal-title":"J Am Soc Nephrol."},{"issue":"4","key":"B77-20250823","doi-asserted-by":"crossref","first-page":"F603","DOI":"10.1152\/ajprenal.00348.2020","article-title":"Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells","volume":"319","author":"Watanabe","year":"2020","journal-title":"Am J Physiol Renal Physiol."},{"issue":"8","key":"B78-20250823","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1016\/j.bbadis.2018.09.025","article-title":"Interplay between NAD+ and acetyl-CoA metabolism in ischemia-induced mitochondrial pathophysiology","volume":"1865","author":"Klimova","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis."},{"issue":"3","key":"B79-20250823","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/FJC.0b013e318273b007","article-title":"Epoxyeicosatrienoic acid pathway in human health and diseases","volume":"61","author":"Bellien","year":"2013","journal-title":"J Cardiovasc Pharmacol."},{"issue":"1","key":"B80-20250823","doi-asserted-by":"crossref","first-page":"e0145645","DOI":"10.1371\/journal.pone.0145645","article-title":"Renal ischemia\/reperfusion injury in soluble epoxide hydrolase-deficient mice","volume":"11","author":"Zhu","year":"2016","journal-title":"PLoS One."},{"issue":"5","key":"B81-20250823","doi-asserted-by":"crossref","first-page":"e0175292","DOI":"10.1371\/journal.pone.0175292","article-title":"Association of gain-of-function EPHX2 polymorphism Lys55Arg with acute kidney injury following cardiac surgery","volume":"12","author":"Shuey","year":"2017","journal-title":"PLoS One."},{"issue":"12","key":"B82-20250823","doi-asserted-by":"crossref","first-page":"23495","DOI":"10.1002\/jcp.28918","article-title":"Sirt3 modulate renal ischemia-reperfusion injury through enhancing mitochondrial fusion and activating the ERK-OPA1 signaling pathway","volume":"234","author":"Wang","year":"2019","journal-title":"J Cell Physiol."},{"key":"B83-20250823","doi-asserted-by":"crossref","first-page":"120005","DOI":"10.1016\/j.lfs.2021.120005","article-title":"SIRT3 protects kidneys from ischemia-reperfusion injury by modulating the DRP1 pathway to induce mitochondrial autophagy","volume":"286","author":"Zhao","year":"2021","journal-title":"Life Sci."},{"issue":"11","key":"B84-20250823","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1093\/ckj\/sfab053","article-title":"Development and design of the hantavirus registry \u2013 HantaReg \u2013 for epidemiological studies, outbreaks and clinical studies on hantavirus disease","volume":"14","author":"Koehler","year":"2021","journal-title":"Clin Kidney J."},{"issue":"8","key":"B85-20250823","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.3945\/jn.114.199380","article-title":"Protein and calorie restriction contribute additively to protection from renal ischemia reperfusion injury partly via leptin reduction in male mice","volume":"145","author":"Robertson","year":"2015","journal-title":"J Nutr."},{"issue":"9","key":"B86-20250823","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41581-020-0309-2","article-title":"Autophagy in kidney homeostasis and disease","volume":"16","author":"Tang","year":"2020","journal-title":"Nat Rev Nephrol."},{"issue":"3","key":"B87-20250823","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.kint.2022.04.033","article-title":"Caloric restriction reduces the pro-inflammatory eicosanoid 20-hydroxyeicosatetraenoic acid to protect from acute kidney injury","volume":"102","author":"Hoyer-Allo","year":"2022","journal-title":"Kidney Int."},{"key":"B88-20250823","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.trsl.2022.02.003","article-title":"A systematic analysis of diet-induced nephroprotection reveals overlapping changes in cysteine catabolism","volume":"244","author":"Koehler","year":"2022","journal-title":"Transl Res."},{"issue":"2","key":"B89-20250823","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00702-011-0681-y","article-title":"The kynurenine system and immunoregulation","volume":"119","author":"M\u00e1ndi","year":"2012","journal-title":"J Neural Transm (Vienna)."},{"issue":"2","key":"B90-20250823","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0002-8703(96)90419-6","article-title":"\u03b2-Estradiol, but not \u03b1-estradiol, reduces myocardial necrosis in rabbits after ischemia and reperfusion","volume":"132","author":"Hale","year":"1996","journal-title":"Am Heart J."},{"issue":"2-3","key":"B91-20250823","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0014-2999(97)01201-6","article-title":"17Beta-oestradiol reduces cardiac leukocyte accumulation in myocardial ischaemia reperfusion injury in rat","volume":"335","author":"Squadrito","year":"1997","journal-title":"Eur J Pharmacol."},{"issue":"6","key":"B92-20250823","doi-asserted-by":"crossref","first-page":"H2766","DOI":"10.1152\/ajpheart.2000.279.6.H2766","article-title":"Effect of estrogen on global myocardial ischemia-reperfusion injury in female rats","volume":"279","author":"Zhai","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol."},{"issue":"2","key":"B93-20250823","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1067\/msy.2002.125718","article-title":"17-Beta-estradiol protects the liver against warm ischemia\/reperfusion injury and is associated with increased serum nitric oxide and decreased tumor necrosis factor-alpha","volume":"132","author":"Eckhoff","year":"2002","journal-title":"Surgery."},{"issue":"23","key":"B94-20250823","doi-asserted-by":"crossref","first-page":"13829","DOI":"10.1073\/pnas.95.23.13829","article-title":"Impaired liver regeneration in inducible nitric oxide synthasedeficient mice","volume":"95","author":"Rai","year":"1998","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B95-20250823","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cophys.2018.03.008","article-title":"Sex differences in the response to dietary restriction in rodents","volume":"6","author":"Kane","year":"2018","journal-title":"Curr Opin Physiol."},{"issue":"6","key":"B96-20250823","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.cmet.2016.05.027","article-title":"Effects of sex, strain, and energy intake on hallmarks of aging in mice","volume":"23","author":"Mitchell","year":"2016","journal-title":"Cell Metab."},{"issue":"50","key":"B97-20250823","doi-asserted-by":"crossref","first-page":"52282","DOI":"10.1074\/jbc.M407629200","article-title":"Testosterone is responsible for enhanced susceptibility of males to ischemic renal injury","volume":"279","author":"Park","year":"2004","journal-title":"J Biol Chem."},{"issue":"4","key":"B98-20250823","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1620\/tjem.218.325","article-title":"Gender differences in the susceptibility to renal ischemia-reperfusion injury in BALB\/c mice","volume":"218","author":"Hu","year":"2009","journal-title":"Tohoku J Exp Med."},{"issue":"5","key":"B99-20250823","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1172\/JCI84712","article-title":"Improved renal ischemia tolerance in females influences kidney transplantation outcomes","volume":"126","author":"Aufhauser","year":"2016","journal-title":"J Clin Invest."},{"issue":"8","key":"B100-20250823","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1681\/ASN.2012070714","article-title":"Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase","volume":"24","author":"Wu","year":"2013","journal-title":"J Am Soc Nephrol."},{"issue":"1","key":"B101-20250823","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/CRD.0b013e3182961659","article-title":"20-HETE and blood pressure regulation: clinical implications","volume":"22","author":"Wu","year":"2014","journal-title":"Cardiol Rev."},{"issue":"12","key":"B102-20250823","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3109\/00498254.2013.797622","article-title":"Hormonal regulation of Cyp4a isoforms in mouse liver and kidney","volume":"43","author":"Zhang","year":"2013","journal-title":"Xenobiotica."},{"issue":"3","key":"B103-20250823","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.devcel.2019.10.005","article-title":"Single-cell profiling reveals sex, lineage, and regional diversity in the mouse kidney","volume":"51","author":"Ransick","year":"2019","journal-title":"Dev Cell."},{"issue":"1","key":"B104-20250823","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1681\/ASN.2019040337","article-title":"Proximal tubule translational profiling during kidney fibrosis reveals proinflammatory and long noncoding RNA expression patterns with sexual dimorphism","volume":"31","author":"Wu","year":"2020","journal-title":"J Am Soc Nephrol."}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.0000000000000087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:43:09Z","timestamp":1786131789000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.0000000000000087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,9]]},"references-count":104,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.0000000000000087","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.08.20.457042","asserted-by":"object"}]},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,9]]},"assertion":[{"value":"2022-03-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}