{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:10:45Z","timestamp":1792987845005,"version":"4.5.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","funder":[{"DOI":"10.13039\/100017051","name":"College of Medicine, Seoul National University","doi-asserted-by":"crossref","award":["800-20190571"],"award-info":[{"award-number":["800-20190571"]}],"id":[{"id":"10.13039\/100017051","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Health and Welfare, Republic of Korea","award":["RS-2024-00403375"],"award-info":[{"award-number":["RS-2024-00403375"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2024-00345867"],"award-info":[{"award-number":["RS-2024-00345867"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Lower bone mineral density was associated with a higher risk of fracture, irrespective of eGFR.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>At a similar bone mineral density, the fracture risk was higher with lower eGFR, more prominently for hip fractures than for vertebral fractures.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The higher risk of fracture associated with lower eGFR was more pronounced in individuals with poor static balance.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although both lower bone mineral density (BMD) and impaired kidney function are well-established risk factors for fracture, large-scale studies evaluating their effects and interaction on fracture, particularly site-specific fractures including vertebra and hip, are still limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The main study population included female participants aged 66 years who underwent BMD assessment through dual-energy x-ray absorptiometry through the Korean National Screening Program between 2010 and 2016. BMD was categorized as normal, osteopenia, and osteoporosis on the basis of\n                      <jats:italic toggle=\"yes\">T<\/jats:italic>\n                      -score. Kidney function was classified as eGFR \u226560, 45\u201359, and &lt;45 ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      . Primary outcome was any fracture, including vertebral, hip, and other fractures, defined using International Classification of Diseases, Tenth Revision codes. Subgroup analysis was performed by physical performance, including the single-leg stance test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 551,548 participants included in the main study population, 80,514 developed any fracture over a median follow-up of 8.2 (interquartile range, 6.7\u201310.0) years. The prevalence of osteoporosis was 36%, and those with lower BMD showed higher eGFR and lower body mass index. Lower BMD was associated with a higher risk of any fracture, irrespective of eGFR, with nonsignificant interaction (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      for interaction = 0.54). Among participants with normal BMD, those with eGFR &lt;45 ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      showed a greater risk of hip fracture than those with normal eGFR (adjusted hazard ratio, 2.44 [1.88\u20133.18]), whereas vertebral fracture risks were similar across different eGFR categories at a given BMD status. Furthermore, a higher fracture risk with lower eGFR was more pronounced in women with poor static balance assessed by the single-leg stance test than in those with normal static balance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In postmenopausal women, lower BMD was associated with a higher fracture risk, irrespective of eGFR. However, at any given BMD, lower eGFR was associated with a greater risk for hip fracture, but not for vertebral fracture.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.0000000960","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T17:20:27Z","timestamp":1764609627000},"page":"984-994","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Bone Mineral Density and the Risk of Fracture According to eGFR in Postmenopausal Women"],"prefix":"10.1681","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-198X","authenticated-orcid":false,"given":"Minsang","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7643-994X","authenticated-orcid":false,"given":"Jeong Min","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6060-9032","authenticated-orcid":false,"given":"Semin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8831-9838","authenticated-orcid":false,"given":"Seong Geun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul, Republic of 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