{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:46:40Z","timestamp":1791996400162,"version":"4.4.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","funder":[{"name":"the National Natural Science Foundation of China","award":["82090022"],"award-info":[{"award-number":["82090022"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the National Natural Science Foundation of China","award":["82171725"],"award-info":[{"award-number":["82171725"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the National Natural Science Foundation of China","award":["82030022"],"award-info":[{"award-number":["82030022"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the National Natural Science Foundation of China","award":["82090023"],"award-info":[{"award-number":["82090023"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the National Natural Science Foundation of China","award":["82330019"],"award-info":[{"award-number":["82330019"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the National Natural Science Foundation of China","award":["82330020"],"award-info":[{"award-number":["82330020"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2023A1515010257"],"award-info":[{"award-number":["2023A1515010257"]}]},{"name":"Key Technologies R&D Program of Guangdong Province","award":["2023B1111030004"],"award-info":[{"award-number":["2023B1111030004"]}]},{"name":"the Program of Introducing Talents of Discipline to Universities, 111 Plan","award":["D18005"],"award-info":[{"award-number":["D18005"]}]},{"name":"Scientific Research Fund of Peking University First Hospital","award":["2023IR16"],"award-info":[{"award-number":["2023IR16"]}],"id":[{"id":"https:\/\/ror.org\/02z1vqm45","id-type":"ROR","asserted-by":"crossref"}]},{"name":"State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University","award":["24QZ003"],"award-info":[{"award-number":["24QZ003"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"published-print":{"date-parts":[[2026,6]]},"abstract":"\n Key Points<\/jats:title>\n \n \n \n Extracellular matrix protein 1 is specifically expressed in glomerular mesangial cells in both human and mice.<\/jats:p>\n <\/jats:list-item>\n \n Loss of extracellular matrix protein 1 leads to excessive mesangial matrix expansion and disrupted glomerular architecture.<\/jats:p>\n <\/jats:list-item>\n \n \n Extracellular matrix protein 1 binds integrin\n \u03b1<\/jats:italic>\n 8\n \u03b2<\/jats:italic>\n 1 to stabilize mesangial cell adhesion to the mesangial matrix and glomerular basement membrane.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n The mesangium consists of mesangial cells and mesangial matrix that maintain normal glomerular structure and function. The mechanisms by which mesangial cells regulate mesangial matrix dynamics remain poorly understood. This study investigated the role of mesangial cell\u2013derived extracellular matrix protein 1 (ECM1) in regulating mesangial matrix homeostasis and glomerular structure in mice.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Immunofluorescence and single-nucleus RNA sequencing were used to clarify the ECM1 expression pattern in kidney. Global and tamoxifen-inducible\n Ecm1<\/jats:italic>\n -knockout (KO) mice demonstrated the\n in vivo<\/jats:italic>\n function of\n Ecm1<\/jats:italic>\n . Immunoprecipitation, mass spectrometry, and RNA-seq were used to reveal the mechanism by which ECM1 regulates mesangial matrix homeostasis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n snRNA-seq and immunofluorescence revealed that ECM1 was specifically expressed in glomerular mesangial cells and downregulated in diabetic kidney disease and IgA nephropathy. Genetic deletion of\n Ecm1<\/jats:italic>\n in mice resulted in mesangial matrix expansion at 4 and 8 weeks of age, whereas early stages appeared unaffected. Similarly, tamoxifen-induced global deletion of\n Ecm1<\/jats:italic>\n in 4-week-old mice led to a trend toward mesangial matrix expansion. Transcriptomic profiling and immunofluorescence confirmed substantial alterations of the mesangial matrix components in\n Ecm1<\/jats:italic>\n -KO kidneys. As a result, histological examination showed profound glomerular abnormalities in\n Ecm1<\/jats:italic>\n -KO mice.\n Ecm1<\/jats:italic>\n deficiency also elevated TGF\n \u03b2<\/jats:italic>\n 1 expression and downstream signaling, likely contributing to the excessive collagen deposition in glomeruli. Mechanistically, ECM1 interacted with integrin\n \u03b1<\/jats:italic>\n 8\n \u03b2<\/jats:italic>\n 1 to promote mesangial cell\u2013matrix adhesion, and loss of this interaction led to mesangial cell disaggregation and detachment from glomerular basement membrane, thereby promoting glomerular pathology. Notably, adeno-associated virus\u2013mediated ECM1 expression\n in vivo<\/jats:italic>\n effectively rescued kidney dysfunction in\n Ecm1<\/jats:italic>\n -KO mice.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n ECM1 was highly expressed in glomerular mesangial cells. Loss of\n Ecm1<\/jats:italic>\n led to altered mesangial matrix composition, matrix expansion, and glomerular abnormalities, while restoration of ECM1 expression reversed these defects, demonstrating an essential role of mesangial cell\u2013derived ECM1 in preserving normal mesangial homeostasis and glomerular structure in mice.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1681\/asn.0000000969","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T17:00:26Z","timestamp":1765558826000},"page":"1206-1220","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Mesangial Cell\u2013Derived Extracellular Matrix Protein 1 Is Essential for Maintaining Mesangial Matrix Homeostasis and Glomerular Architecture"],"prefix":"10.1681","volume":"37","author":[{"given":"Pei","family":"Deng","sequence":"first","affiliation":[{"name":"Division of Nephrology, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Nephrology, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieli","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyin","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Nephrology, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Nephrology, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Luo","sequence":"additional","affiliation":[{"name":"Division of Nephrology, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0850-8135","authenticated-orcid":false,"given":"Enguang","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Guangdong Provincial Key Laboratory of Single Cell Technology and Application, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9212-9670","authenticated-orcid":false,"given":"Nannan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Nie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vascular Homeostasis and Remodeling, Biobank of Peking University First Hospital, Peking University Health Science Center, Peking University First Hospital, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3117-7418","authenticated-orcid":false,"given":"Fan Fan","family":"Hou","sequence":"additional","affiliation":[{"name":"Division of Nephrology, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9511-9383","authenticated-orcid":false,"given":"Yu","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, National Clinical Research Center for Kidney Disease, Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"issue":"4","key":"B1-20261014","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41581-021-00528-x","article-title":"Biomimetic models of the glomerulus","volume":"18","author":"Valverde","year":"2022","journal-title":"Nat Rev Nephrol."},{"issue":"4","key":"B2-20261014","doi-asserted-by":"crossref","first-page":"e13592","DOI":"10.1111\/apha.13592","article-title":"Mesangial cells regulate the single nephron GFR and preserve the integrity of the glomerular filtration barrier: an intravital multiphoton microscopy study","volume":"231","author":"Ziegler","year":"2021","journal-title":"Acta Physiol (Oxf)."},{"issue":"4","key":"B3-20261014","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1681\/ASN.2018020200","article-title":"Maintenance and breakdown of 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Demonstration of alternative splicing in skin and cartilage","volume":"270","author":"Bhalerao","year":"1995","journal-title":"J Biol Chem."},{"issue":"7","key":"B17-20261014","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/hmg\/11.7.833","article-title":"Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1)","volume":"11","author":"Hamada","year":"2002","journal-title":"Hum Mol Genet."},{"issue":"2","key":"B18-20261014","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2133.1985.tb02056.x","article-title":"Lipoid proteinosis: an inherited disorder of collagen metabolism?","volume":"113","author":"Harper","year":"1985","journal-title":"Br J Dermatol."},{"issue":"3","key":"B19-20261014","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jdermsci.2006.01.004","article-title":"Vascular anomalies in lipoid proteinosis (hyalinosis cutis et mucosae): basement membrane components and 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