{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:44:57Z","timestamp":1792251897103,"version":"4.4.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"abstract":"<jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Renin deficiency in renin-lineage cells worsened crescentic GN and was associated with lower glomerular cell migration.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Loss of renin altered immune-associated, metabolic, and migratory transcriptional programs in renin-lineage cells.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Renin-lineage cell ablation reduced macrophage\/leukocyte infiltration but had limited effects on overall disease severity.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The adult juxtaglomerular renin-lineage cell niche demonstrates cellular plasticity after injury, but its role in highly inflammatory crescentic GN remains unclear. While renin-angiotensin signaling promotes fibrosis and inflammation, the contribution of the renin-lineage cells and renin expression within these cells to crescentic GN has not been investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used tdTomato lineage tracing to track renin-lineage cells in wild-type (WT) and renin-knockout (RenKO) mice after crescentic GN induction. Renin-lineage cell migration and glomerular injury were quantified histologically. Single-cell RNA sequencing was performed on isolated tdTomato-positive cells on days 10 and 21 after injury to characterize transcriptional programs. Disease progression was additionally examined in mice with diphtheria toxin A\u2013mediated renin-lineage cell ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Renin-lineage cells were detected within injured glomeruli during crescentic GN. Genetic renin deletion worsened disease outcomes, with RenKO mice developing increased albuminuria (by 3-fold), crescent formation (by 50%), and podocyte loss (by 15%) by day 21 compared with WT controls. Renin-deficient renin-lineage cells exhibited reduced glomerular migration and decreased colocalization with mesangial cell markers. Single-cell transcriptomic analysis revealed distinct transcriptional programs between WT and RenKO renin-lineage cells, with RenKO cells enriched for IFN-stimulated and reduced migration-associated pathways. Renin-lineage cell ablation reduced macrophage infiltration but did not alter disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Renin expression influenced migration and injury-associated responses of renin-lineage cells during crescentic GN. Loss of renin was associated with a dysfunctional IFN-driven and antimigratory phenotype together with more severe glomerular injury, whereas renin-lineage cell ablation reduced macrophage infiltration but had limited effects on overall disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.0000001239","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:00:31Z","timestamp":1787587231000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Renin Is Critical for Renin-Lineage Cell Plasticity, Migration, and Disease Outcome in Experimental Crescentic GN"],"prefix":"10.1681","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2908-3627","authenticated-orcid":false,"given":"Shila","family":"Azizolli","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, Division of Nephrology, University Hospital Carl Gustav Carus at the Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9863-2764","authenticated-orcid":false,"given":"Sagor","family":"Halder","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Nephrology, University Hospital Carl Gustav Carus at the Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8698-0076","authenticated-orcid":false,"given":"Anne","family":"Steglich","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Nephrology, University Hospital Carl Gustav Carus at the Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5866-1403","authenticated-orcid":false,"given":"Akua","family":"Annoh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Nephrology, University Hospital Carl Gustav Carus at the Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2739-345X","authenticated-orcid":false,"given":"Florian","family":"Gembardt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Nephrology, University Hospital Carl Gustav Carus at the Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"5th Department of Medicine, Mannheim Medical Faculty, Heidelberg University, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5056-6921","authenticated-orcid":false,"given":"Irina","family":"Simonova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Nephrology, University Hospital Carl Gustav Carus at the Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4738-8933","authenticated-orcid":false,"given":"Jan","family":"Sradnick","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Nephrology, University Hospital Carl Gustav Carus at the Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2668-8371","authenticated-orcid":false,"given":"Andreas","family":"Dahl","sequence":"additional","affiliation":[{"name":"DRESDEN-Concept Genome Center (DcGC), Center for Molecular and Cellular Bioengineering (CMCB) Technology Platform, TUD Dresden University of Technology, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3342-2122","authenticated-orcid":false,"given":"Rajinder","family":"Gupta","sequence":"additional","affiliation":[{"name":"DRESDEN-Concept Genome Center (DcGC), Center for Molecular and Cellular Bioengineering (CMCB) Technology Platform, TUD Dresden University of Technology, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan R.","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Nephrology, University Hospital Carl Gustav Carus at the Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Department of Environmental and Public Health, College of Health Sciences, Abu Dhabi University, Abu Dhabi, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7011-8130","authenticated-orcid":false,"given":"Vladimir","family":"Todorov","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Nephrology, University Hospital Carl Gustav Carus at the Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Center of Biomedical Education and Research (ZBAF), Faculty of Health, Institute of Physiology, and Pathophysiology, Witten\/Herdecke University, Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-4368","authenticated-orcid":false,"given":"Hannah","family":"Weissbach","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Nephrology, University Hospital Carl Gustav Carus at the Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hugo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Nephrology, University Hospital Carl Gustav Carus at the Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"issue":"2","key":"B1-20261017","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00441-021-03509-5","article-title":"Immune-mediated glomerular diseases: new basic concepts and clinical implications","volume":"385","author":"Panzer","year":"2021","journal-title":"Cell Tissue Res."},{"issue":"6","key":"B2-20261017","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0272-6386(88)80079-9","article-title":"Rapidly progressive glomerulonephritis: classification, pathogenetic mechanisms, and therapy","volume":"11","author":"Couser","year":"1988","journal-title":"Am J Kidney Dis."},{"issue":"3","key":"B3-20261017","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1046\/j.1523-1755.2003.00843.x","article-title":"Rapidly progressive crescentic glomerulonephritis","volume":"63","author":"Jennette","year":"2003","journal-title":"Kidney Int."},{"issue":"12","key":"B4-20261017","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1681\/ASN.2009010122","article-title":"Tracing the origin of glomerular extracapillary lesions from parietal epithelial cells","volume":"20","author":"Smeets","year":"2009","journal-title":"J Am Soc Nephrol."},{"key":"B5-20261017","doi-asserted-by":"crossref","first-page":"724186","DOI":"10.3389\/fphys.2021.724186","article-title":"Crescentic glomerulonephritis: pathogenesis and therapeutic potential of human amniotic stem cells","volume":"12","author":"Al Mushafi","year":"2021","journal-title":"Front Physiol."},{"issue":"3","key":"B6-20261017","doi-asserted-by":"crossref","first-page":"F378","DOI":"10.1152\/ajprenal.00151.2021","article-title":"Patterns of differentiation of renin lineage cells during nephrogenesis","volume":"321","author":"Kessel","year":"2021","journal-title":"Am J Physiol Renal Physiol."},{"issue":"8","key":"B7-20261017","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/HYPERTENSIONAHA.123.20577","article-title":"Renin cells, from vascular development to blood pressure sensing","volume":"80","author":"Yamaguchi","year":"2023","journal-title":"Hypertension."},{"key":"B8-20261017","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/112_2020_27","article-title":"Beyond the paradigm: novel functions of renin-producing cells","volume":"177","author":"Steglich","year":"2020","journal-title":"Rev Physiol Biochem Pharmacol."},{"issue":"5","key":"B9-20261017","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S1534-5807(04)00134-0","article-title":"Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened","volume":"6","author":"Sequeira Lopez","year":"2004","journal-title":"Dev Cell."},{"issue":"5","key":"B10-20261017","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.kint.2018.01.014","article-title":"Detection of renin lineage cell transdifferentiation to podocytes in the kidney glomerulus with dual lineage tracing","volume":"93","author":"Eng","year":"2018","journal-title":"Kidney Int."},{"issue":"2","key":"B11-20261017","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.ajpath.2013.04.024","article-title":"Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease","volume":"183","author":"Pippin","year":"2013","journal-title":"Am J Pathol."},{"issue":"1","key":"B12-20261017","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1681\/ASN.2014030265","article-title":"Renin lineage cells repopulate the glomerular mesangium after injury","volume":"26","author":"Starke","year":"2015","journal-title":"J Am Soc Nephrol."},{"issue":"2","key":"B13-20261017","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/HYPERTENSIONAHA.123.21372","article-title":"Elusive and heterogenous nature of renin cells","volume":"81","author":"Almeida","year":"2024","journal-title":"Hypertension."},{"issue":"1","key":"B14-20261017","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.1038\/s41598-021-86629-w","article-title":"A primitive type of renin-expressing lymphocyte protects the organism against infections","volume":"11","author":"Belyea","year":"2021","journal-title":"Sci Rep."},{"issue":"7","key":"B15-20261017","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.3390\/biomedicines13071779","article-title":"Immunomodulatory effects of RAAS inhibitors: beyond hypertension and heart failure","volume":"13","author":"Haliga","year":"2025","journal-title":"Biomedicines."},{"issue":"7","key":"B16-20261017","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3390\/ijms17070797","article-title":"Role of the renin-angiotensin-aldosterone system beyond blood pressure regulation: molecular and cellular mechanisms involved in end-organ damage during arterial hypertension","volume":"17","author":"Munoz-Durango","year":"2016","journal-title":"Int J Mol Sci."},{"issue":"7","key":"B17-20261017","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/emmm.201000080","article-title":"Angiotensin II revisited: new roles in inflammation, immunology and aging","volume":"2","author":"Benigni","year":"2010","journal-title":"EMBO Mol Med."},{"issue":"12","key":"B18-20261017","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1681\/ASN.2017020173","article-title":"Interference with Gsalpha-coupled receptor signaling in renin-producing cells leads to renal endothelial damage","volume":"28","author":"Lachmann","year":"2017","journal-title":"J Am Soc Nephrol."},{"issue":"9","key":"B19-20261017","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s00424-019-02298-9","article-title":"Renin cells with defective Gsalpha\/cAMP signaling contribute to renal endothelial damage","volume":"471","author":"Steglich","year":"2019","journal-title":"Pflugers Arch."},{"issue":"5","key":"B20-20261017","doi-asserted-by":"crossref","first-page":"F783","DOI":"10.1152\/ajprenal.00279.2012","article-title":"Transcutaneous measurement of renal function in conscious mice","volume":"303","author":"Schreiber","year":"2012","journal-title":"Am J Physiol Renal Physiol."},{"key":"B21-20261017","doi-asserted-by":"crossref","first-page":"982722","DOI":"10.3389\/fphys.2022.982722","article-title":"Intravital imaging of hemodynamic glomerular effects of enalapril or\/and empagliflozin in STZ-diabetic mice","volume":"13","author":"Kroeger","year":"2022","journal-title":"Front Physiol."},{"issue":"5","key":"B22-20261017","doi-asserted-by":"crossref","first-page":"F1299","DOI":"10.1152\/ajprenal.00254.2009","article-title":"Thrombospondin-2 therapy ameliorates experimental glomerulonephritis via inhibition of cell proliferation, inflammation, and TGF-beta activation","volume":"297","author":"Daniel","year":"2009","journal-title":"Am J Physiol Renal Physiol."},{"key":"B23-20261017","doi-asserted-by":"crossref","first-page":"109335","DOI":"10.1016\/j.cellsig.2019.05.020","article-title":"New automatic quantification method of immunofluorescence and histochemistry in whole histological sections","volume":"62","author":"Kessel","year":"2019","journal-title":"Cell Signal."},{"issue":"6","key":"B24-20261017","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1681\/ASN.2015030321","article-title":"Extrarenal progenitor cells do not contribute to renal endothelial repair","volume":"27","author":"Sradnick","year":"2016","journal-title":"J Am Soc Nephrol."},{"issue":"6","key":"B27-20261017","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.kint.2017.04.014","article-title":"Persistent and inducible neogenesis repopulates progenitor renin lineage cells in the kidney","volume":"92","author":"Hickmann","year":"2017","journal-title":"Kidney Int."},{"issue":"4","key":"B28-20261017","doi-asserted-by":"crossref","first-page":"e14014","DOI":"10.1111\/apha.14014","article-title":"Cells of the renin lineage promote kidney regeneration post-release of ureteral obstruction in neonatal mice","volume":"238","author":"Nagalakshmi","year":"2023","journal-title":"Acta Physiol (Oxf)."},{"issue":"4","key":"B29-20261017","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrneph.2017.186","article-title":"Renin cells in homeostasis, regeneration and immune defence mechanisms","volume":"14","author":"Gomez","year":"2018","journal-title":"Nat Rev Nephrol."},{"issue":"8","key":"B30-20261017","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00424-022-02694-8","article-title":"Flexible and multifaceted: the plasticity of renin-expressing cells","volume":"474","author":"Broeker","year":"2022","journal-title":"Pflugers Arch."},{"issue":"3","key":"B31-20261017","doi-asserted-by":"crossref","first-page":"R474","DOI":"10.1152\/ajpregu.00426.2003","article-title":"Ablation of renin-expressing juxtaglomerular cells results in a distinct kidney phenotype","volume":"286","author":"Pentz","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"issue":"24","key":"B32-20261017","doi-asserted-by":"crossref","first-page":"e154337","DOI":"10.1172\/jci.insight.154337","article-title":"Inhibition of the renin-angiotensin system causes concentric hypertrophy of renal arterioles in mice and humans","volume":"6","author":"Watanabe","year":"2021","journal-title":"JCI Insight."},{"issue":"7","key":"B33-20261017","doi-asserted-by":"crossref","first-page":"e68167","DOI":"10.1371\/journal.pone.0068167","article-title":"Distinct contributions of TNF receptor 1 and 2 to TNF-induced glomerular inflammation in mice","volume":"8","author":"Taubitz","year":"2013","journal-title":"PLoS One."},{"issue":"4","key":"B34-20261017","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1681\/ASN.2011050449","article-title":"Subtotal ablation of parietal epithelial cells induces crescent formation","volume":"23","author":"Sicking","year":"2012","journal-title":"J Am Soc Nephrol."},{"issue":"1","key":"B35-20261017","first-page":"20","article-title":"Nephrotoxic nephritis in nude mice","volume":"46","author":"Kusuyama","year":"1981","journal-title":"Clin Exp Immunol."},{"issue":"5","key":"B36-20261017","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.kint.2016.10.037","article-title":"Glomerular common gamma chain confers B- and T-cell-independent protection against glomerulonephritis","volume":"91","author":"Luque","year":"2017","journal-title":"Kidney Int."},{"issue":"5","key":"B37-20261017","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1681\/ASN.2008050556","article-title":"The IL-23\/Th17 axis contributes to renal injury in experimental glomerulonephritis","volume":"20","author":"Paust","year":"2009","journal-title":"J Am Soc Nephrol."},{"issue":"10","key":"B38-20261017","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41419-024-07103-9","article-title":"High mitochondrial DNA content is a key determinant of stemness, proliferation, cell migration, and cancer metastasis in vivo","volume":"15","author":"Mauro-Lizcano","year":"2024","journal-title":"Cell Death Dis."},{"issue":"2","key":"B39-20261017","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ajpath.2013.04.017","article-title":"The antiviral cytokines IFN-alpha and IFN-beta modulate parietal epithelial cells and promote podocyte loss: implications for IFN toxicity, viral glomerulonephritis, and glomerular regeneration","volume":"183","author":"Migliorini","year":"2013","journal-title":"Am J Pathol."},{"issue":"1","key":"B40-20261017","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1038\/s41467-025-59819-7","article-title":"Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice","volume":"16","author":"Wang","year":"2025","journal-title":"Nat Commun."},{"issue":"3","key":"B41-20261017","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1046\/j.1365-2249.2002.01859.x","article-title":"Effects of CTLA4-Fc on glomerular injury in humorally-mediated glomerulonephritis in BALB\/c mice","volume":"128","author":"Kitching","year":"2002","journal-title":"Clin Exp Immunol."},{"key":"B42-20261017","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/B978-0-12-800100-4.00005-2","article-title":"The CD200-CD200R1 inhibitory signaling pathway: immune regulation and host-pathogen interactions","volume":"121","author":"Vaine","year":"2014","journal-title":"Adv Immunol."},{"issue":"7841","key":"B43-20261017","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41586-020-2941-1","article-title":"Decoding myofibroblast origins in human kidney fibrosis","volume":"589","author":"Kuppe","year":"2021","journal-title":"Nature."},{"issue":"9","key":"B44-20261017","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/ki.2011.217","article-title":"Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis","volume":"80","author":"Anders","year":"2011","journal-title":"Kidney Int."},{"issue":"12","key":"B45-20261017","doi-asserted-by":"crossref","first-page":"e1005734","DOI":"10.1371\/journal.pgen.1005734","article-title":"The inflammatory transcription factors NFkappaB, STAT1 and STAT3 drive age-associated transcriptional changes in the human kidney","volume":"11","author":"O'Brown","year":"2015","journal-title":"PLoS Genet."},{"issue":"9","key":"B46-20261017","doi-asserted-by":"crossref","first-page":"e126183","DOI":"10.1172\/jci.insight.126183","article-title":"Signaling pathways predisposing to chronic kidney disease progression","volume":"5","author":"Zaidan","year":"2020","journal-title":"JCI Insight."},{"issue":"10","key":"B47-20261017","doi-asserted-by":"crossref","first-page":"110473","DOI":"10.1016\/j.celrep.2022.110473","article-title":"Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration","volume":"38","author":"Ajay","year":"2022","journal-title":"Cell Rep."},{"issue":"6","key":"B48-20261017","doi-asserted-by":"crossref","first-page":"F1151","DOI":"10.1152\/ajprenal.00034.2019","article-title":"Targeting STAT3 signaling in kidney disease","volume":"316","author":"Pace","year":"2019","journal-title":"Am J Physiol Renal Physiol."},{"issue":"7","key":"B49-20261017","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.7150\/ijbs.71595","article-title":"Smad3 signatures in renal inflammation and fibrosis","volume":"18","author":"Wu","year":"2022","journal-title":"Int J Biol Sci."},{"key":"B50-20261017","doi-asserted-by":"crossref","first-page":"4609502","DOI":"10.1155\/2017\/4609502","article-title":"Endothelial STAT3 modulates protective mechanisms in a mouse ischemia-reperfusion model of acute kidney injury","volume":"2017","author":"Dube","year":"2017","journal-title":"J Immunol Res."}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.0000001239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:01:23Z","timestamp":1792249283000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.0000001239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":48,"URL":"https:\/\/doi.org\/10.1681\/asn.0000001239","relation":{},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]},"assertion":[{"value":"2026-02-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}