{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:51:56Z","timestamp":1791564716490,"version":"4.3.4"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"abstract":"\n Background:<\/jats:title>\n Activated parietal epithelial cells (PECs) and podocytes are key effector cells in the development of crescentic glomerulonephritis and focal segmental glomerulosclerosis (FSGS). Platelet-derived growth factor (PDGF)-C has been found to be important for tubulointerstitial fibrosis development, but its relevance for crescentic glomerulonephritis and FSGS was previously unknown.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n To address this, expression analyses for both PDGF-C and its receptor PDGFR\u03b1 were carried out in mouse and human kidney tissues. To further elucidate a functional role of PDGF-C, the murine nephrotoxic nephritis model of crescentic glomerulonephritis was induced in a)\n Pdgfc<\/jats:italic>\n -deficient mice, b) mice treated with a neutralizing PDGF-C antibody, and c)\n Pax8-cre::Pdgfc<\/jats:italic>\n fl<\/jats:sup>\n \/<\/jats:italic>\n fl<\/jats:sup>\n mice with conditional\n Pdgfc<\/jats:italic>\n deletion in kidney epithelial cells. We also subjected the collapsing FSGS model of the anti-Thy1.1 transgenic mouse to pharmacological PDGF-C inhibition. The studies were supplemented by PEC\n in vitro<\/jats:italic>\n analyses.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Our data showed that PDGF-C was upregulated in PECs and expressed\n de novo<\/jats:italic>\n in podocytes under disease conditions. It promoted the proliferation and activation of primary as well as conditionally immortalized PECs\n in vitro<\/jats:italic>\n . In both the genetic and pharmacological PDGF-C intervention studies in murine crescentic glomerulonephritis and FSGS, significant improvements in glomerular crescent formation, glomerular sclerosis, renal inflammation and kidney function parameters were observed upon PDGF-C deficiency or antagonism. Mechanistically, transcription factor FOXM1 was identified as a mediator of disease-related PDGF-C expression in PECs.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Our studies identified epithelial PDGF-C as a contributor to disease progression in crescentic glomerulonephritis and FSGS, acting in part through the activation of parietal epithelial cells.<\/jats:p>\n <\/jats:sec>","DOI":"10.1681\/asn.0000001274","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:01:38Z","timestamp":1791561698000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Epithelial PDGF-C Contributes to Crescentic Glomerulonephritis and FSGS in Part via Activation of Parietal Epithelial Cells"],"prefix":"10.1681","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1638-8604","authenticated-orcid":false,"given":"Ina V.","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension, Rheumatology and Immunology (Medical Clinic II), Medical Faculty RWTH Aachen, Aachen, Germany; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Dusseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8337-0637","authenticated-orcid":false,"given":"Yingying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Rheumatology and Immunology (Medical Clinic II), Medical Faculty RWTH Aachen, Aachen, Germany; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Dusseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4798-2908","authenticated-orcid":false,"given":"Dickson W.L.","family":"Wong","sequence":"additional","affiliation":[{"name":"Institute of Pathology, RWTH Aachen University, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8527-7353","authenticated-orcid":false,"given":"Roman D.","family":"B\u00fclow","sequence":"additional","affiliation":[{"name":"Institute of Pathology, RWTH Aachen University, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0838-8137","authenticated-orcid":false,"given":"Mirna","family":"Barsoum","sequence":"additional","affiliation":[{"name":"Proteomics Facility of the Interdisciplinary Center for Clinical Research (IZKF), Medical Faculty RWTH Aachen, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9272-3980","authenticated-orcid":false,"given":"Lisa","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Pathology, RWTH Aachen University, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6095-3258","authenticated-orcid":false,"given":"Rachel P.L.","family":"van Swelm","sequence":"additional","affiliation":[{"name":"Translational Metabolic Laboratory (TML 830), Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9921-4284","authenticated-orcid":false,"given":"Peter","family":"Boor","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Rheumatology and Immunology (Medical Clinic II), Medical Faculty RWTH Aachen, Aachen, Germany; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Dusseldorf"},{"name":"Institute of Pathology, RWTH Aachen University, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4439-3980","authenticated-orcid":false,"given":"Ulf","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4162-9107","authenticated-orcid":false,"given":"Maja T.","family":"Lindenmeyer","sequence":"additional","affiliation":[{"name":"III Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"},{"name":"Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens D.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Nephrological Center, Medical Clinic and Policlinic IV, University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9449-0722","authenticated-orcid":false,"given":"Ulf","family":"Panzer","sequence":"additional","affiliation":[{"name":"Hamburg Center for Translational Immunology (HCTI), III. Department of Medicine, Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2739-5578","authenticated-orcid":false,"given":"Christian F.","family":"Krebs","sequence":"additional","affiliation":[{"name":"Hamburg Center for Translational Immunology (HCTI), III. Department of Medicine, Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-6351","authenticated-orcid":false,"given":"Rafael","family":"Kramann","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Rheumatology and Immunology (Medical Clinic II), Medical Faculty RWTH Aachen, Aachen, Germany; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Dusseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Floege","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Rheumatology and Immunology (Medical Clinic II), Medical Faculty RWTH Aachen, Aachen, Germany; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Dusseldorf"},{"name":"Department of Cardiology, RWTH Aachen University, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7236-9793","authenticated-orcid":false,"given":"Ute","family":"Raffetseder","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Rheumatology and Immunology (Medical Clinic II), Medical Faculty RWTH Aachen, Aachen, Germany; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Dusseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8466-3367","authenticated-orcid":false,"given":"Bart","family":"Smeets","sequence":"additional","affiliation":[{"name":"Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4783-9669","authenticated-orcid":false,"given":"Gerald S.","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Rheumatology and Immunology (Medical Clinic II), Medical Faculty RWTH Aachen, Aachen, Germany; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Dusseldorf"},{"name":"Department of Nephrology, Klinikum Coburg, Coburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7472-4907","authenticated-orcid":false,"given":"Eleni","family":"Stamellou","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Rheumatology and Immunology (Medical Clinic II), Medical Faculty RWTH Aachen, Aachen, Germany; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Dusseldorf"},{"name":"Department of Nephrology, School of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2889-5371","authenticated-orcid":false,"given":"Tammo","family":"Ostendorf","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Rheumatology and Immunology (Medical Clinic II), Medical Faculty RWTH Aachen, Aachen, Germany; Center of Excellence in Nephrology, University Hospitals Aachen, Cologne, Dusseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,10,9]]},"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.0000001274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:01:39Z","timestamp":1791561699000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.0000001274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1681\/asn.0000001274","relation":{},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]},"assertion":[{"value":"2026-03-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}