{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:46:55Z","timestamp":1791823615135,"version":"4.3.4"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"abstract":"\n Background:<\/jats:title>\n Aging is associated with declining kidney health as defined by lower eGFR and higher albuminuria. Age-related changes in kidney tubule health have not been well studied.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We analyzed a subset of participants from 2 cohorts, the Coronary Artery Risk Development in Young Adults (CARDIA) Year 20 (n=939) and the Multi-Ethnic Study of Atherosclerosis (MESA) Exam 1 (n=1,014); 780 and 668, respectively, who completed 10-year follow-up. Seven urine biomarkers were measured reflecting tubular synthetic function (EGF and UMOD), tubule reabsorption function (\u03b11m), proximal tubular injury (IL-18 and KIM-1), and interstitial fibrosis\/repair (MCP-1 and YKL-40), and were compared with albuminuria and eGFR. In pooled data, cross-sectional analyses evaluated age associations across the range of 37-84 years, and longitudinal analyses were performed to quantify changes over 10-years of follow-up.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Age ranges were 37-55 and 45-84 years for CARDIA and MESA at baseline, respectively; mean eGFR was 96\u00b115 and 78\u00b116 ml\/min\/1.73m\n 2<\/jats:sup>\n , and median urine albumin-to-creatinine ratios (UACR) were 4.5 [IQR: 3.3, 1.2] and 5.2 [3.3, 11] mg\/g. In multivariable cross-sectional analyses, older age (per decade) was associated with higher urine \u03b11m\/UCr (23%, 95% CI: 17, 28%), IL-18\/UCr (5%: 0.4, 9%), KIM-1\/UCr (16%:12, 20%), MCP-1\/UCr (20%: 16, 23%), YKL-40\/UCr (12%: 5, 20%), UACR (30%: 23, 38%), and lower urine EGF\/UCr (-13%: -15, -11%) and eGFR (-9%; -10, -8%). Age at baseline was not significantly associated with urine UMOD\/UCr. In longitudinal analyses over 10-years of follow up, EGF\/UCr (-20%: 95% CI: -22, -19%) and UMOD\/UCr (-22%: -25, -18%) decreased and \u03b11m\/UCr (30%: 24, 35%), MCP-1\/UCr (9%: 6, 13%), and YKL-40\/UCr (29%: 20, 39%) increased; additionally, albuminuria increased by 29% (23, 36%) and eGFR decreased by 10% (9, 10.4%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n In community-based adults aged 37\u201384 years, aging was associated with worsening tubular function and injury.<\/jats:p>\n <\/jats:sec>","DOI":"10.1681\/asn.0000001284","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:00:24Z","timestamp":1791820824000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Kidney Tubule Aging Across Adulthood"],"prefix":"10.1681","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6567-7629","authenticated-orcid":false,"given":"Merve","family":"Postalcioglu","sequence":"first","affiliation":[{"name":"Kidney Health Research Collaborative, San Francisco VA Healthcare System, and University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7723-7469","authenticated-orcid":false,"given":"Ronit","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1860-6302","authenticated-orcid":false,"given":"Mark J.","family":"Sarnak","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Tufts Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6593-3571","authenticated-orcid":false,"given":"Orlando M.","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7232-0543","authenticated-orcid":false,"given":"David R.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6449-4535","authenticated-orcid":false,"given":"Ankeet S.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California, Oakland, California; Department of Cardiology, Kaiser Permanente San Francisco Medical Center, San Francisco, California; Department of Medicine, Stanford University, Palo Alto, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2301-5796","authenticated-orcid":false,"given":"Cora E.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8084-9869","authenticated-orcid":false,"given":"Joachim H.","family":"Ix","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, University of California San Diego and San Diego VA Healthcare System, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9559-204X","authenticated-orcid":false,"given":"Michael G.","family":"Shlipak","sequence":"additional","affiliation":[{"name":"Kidney Health Research Collaborative, San Francisco VA Healthcare System, and University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,10,12]]},"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.0000001284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:00:25Z","timestamp":1791820825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.0000001284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,12]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1681\/asn.0000001284","relation":{},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,12]]},"assertion":[{"value":"2026-04-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}