{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:28:39Z","timestamp":1790652519881,"version":"4.1.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1681\/asn.2009020188","type":"journal-article","created":{"date-parts":[[2009,10,22]],"date-time":"2009-10-22T22:24:43Z","timestamp":1256250283000},"page":"2570-2580","source":"Crossref","is-referenced-by-count":59,"title":["Cystin Localizes to Primary Cilia via Membrane Microdomains and a Targeting Motif"],"prefix":"10.1681","volume":"20","author":[{"given":"Binli","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Siroky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Kappes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kispert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Guay-Woodford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20230410","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/ki.1994.354","article-title":"Hereditary and acquired cystic disease of the kidney","volume":"46","author":"Fick","year":"1994","journal-title":"Kidney Int"},{"key":"R2-15-20230410","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1056\/NEJMra022161","article-title":"Polycystic kidney disease","volume":"350","author":"Wilson","year":"2004","journal-title":"N Engl J Med"},{"key":"R3-15-20230410","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s00467-006-0164-9","article-title":"Renal cystic diseases: Diverse phenotypes converge on the cilium\/centrosome complex","volume":"21","author":"Guay-Woodford","year":"2006","journal-title":"Pediatr Nephrol"},{"key":"R4-15-20230410","doi-asserted-by":"crossref","first-page":"F1034","DOI":"10.1152\/ajprenal.00195.2003","article-title":"Murine models of polycystic kidney disease: Molecular and therapeutic insights","volume":"285","author":"Guay-Woodford","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"R5-15-20230410","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/nrg1727","article-title":"Cilia and centrosomes: A unifying pathogenic concept for cystic kidney disease?","volume":"6","author":"Hildebrandt","year":"2005","journal-title":"Nat Rev Genet"},{"key":"R6-15-20230410","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ncpneph0070","article-title":"Mechanisms of disease: Autosomal dominant and recessive polycystic kidney diseases","volume":"2","author":"Torres","year":"2006","journal-title":"Nat Clin Pract Nephrol"},{"key":"R7-15-20230410","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1681\/ASN.2006111215","article-title":"Role of primary cilia in the pathogenesis of polycystic kidney disease","volume":"18","author":"Yoder","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"R8-15-20230410","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000163955","article-title":"Primary cilia in normal and pathological tissues","volume":"63","author":"Wheatley","year":"1995","journal-title":"Pathobiology"},{"key":"R9-15-20230410","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/cbir.1996.0011","article-title":"Expression of primary cilia in mammalian cells","volume":"20","author":"Wheatley","year":"1996","journal-title":"Cell Biol Int"},{"key":"R10-15-20230410","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0092-8674(03)00511-7","article-title":"Two populations of node monocilia initiate left-right asymmetry in the mouse","volume":"114","author":"McGrath","year":"2003","journal-title":"Cell"},{"key":"R11-15-20230410","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00232-001-0075-4","article-title":"Bending the MDCK cell primary cilium increases intracellular calcium","volume":"184","author":"Praetorius","year":"2001","journal-title":"J Membr Biol"},{"key":"R12-15-20230410","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ng1076","article-title":"Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells","volume":"33","author":"Nauli","year":"2003","journal-title":"Nat Genet"},{"key":"R13-15-20230410","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0962-8924(02)02410-8","article-title":"Intraflagellar transport and cilia-dependent diseases","volume":"12","author":"Pazour","year":"2002","journal-title":"Trends Cell Biol"},{"key":"R14-15-20230410","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s004240000492","article-title":"Molecular physiology of odor detection: Current views","volume":"441","author":"Paysan","year":"2001","journal-title":"Pflugers Arch"},{"key":"R15-15-20230410","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1172\/JCI0214099","article-title":"Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease","volume":"109","author":"Hou","year":"2002","journal-title":"J Clin Invest"},{"key":"R16-15-20230410","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1097\/01.ASN.0000029587.47950.25","article-title":"The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia","volume":"13","author":"Yoder","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R17-15-20230410","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0092-8674(94)90104-X","article-title":"Myristoylation and palmitoylation of SRC family members: The fats of the matter","volume":"76","author":"Resh","year":"1994","journal-title":"Cell"},{"key":"R18-15-20230410","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-4889(99)00075-0","article-title":"Fatty acylation of proteins: New insights into membrane targeting of myristoylated and palmitoylated proteins","volume":"1451","author":"Resh","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"R19-15-20230410","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/978-1-4757-5806-1_6","article-title":"Membrane targeting of lipid modified signal transduction proteins","volume":"37","author":"Resh","year":"2004","journal-title":"Subcell Biochem"},{"key":"R20-15-20230410","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/42408","article-title":"Functional rafts in cell membranes","volume":"387","author":"Simons","year":"1997","journal-title":"Nature"},{"key":"R21-15-20230410","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1194\/jlr.E600002-JLR200","article-title":"Rafts defined: A report on the Keystone symposium on lipid rafts and cell function","volume":"47","author":"Pike","year":"2006","journal-title":"J Lipid Res"},{"key":"R22-15-20230410","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1194\/jlr.D400041-JLR200","article-title":"A simplified method for the preparation of detergent-free lipid rafts","volume":"46","author":"Macdonald","year":"2005","journal-title":"J Lipid Res"},{"key":"R23-15-20230410","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1128\/jvi.68.4.2556-2569.1994","article-title":"Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids","volume":"68","author":"Zhou","year":"1994","journal-title":"J Virol"},{"key":"R24-15-20230410","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1242\/jcs.02818","article-title":"Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif","volume":"119","author":"Geng","year":"2006","journal-title":"J Cell Sci"},{"key":"R25-15-20230410","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.cub.2006.04.034","article-title":"Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17","volume":"16","author":"Jenkins","year":"2006","journal-title":"Curr Biol"},{"key":"R26-15-20230410","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/emboj.2008.267","article-title":"Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4","volume":"28","author":"Mazelova","year":"2009","journal-title":"EMBO J"},{"key":"R27-15-20230410","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1053\/snep.2001.20929","article-title":"The genetics and physiology of polycystic kidney disease","volume":"21","author":"Calvet","year":"2001","journal-title":"Semin Nephrol"},{"key":"R28-15-20230410","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1242\/dev.02595","article-title":"The roles of cilia in developmental disorders and disease","volume":"133","author":"Bisgrove","year":"2006","journal-title":"Development"},{"key":"R29-15-20230410","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/01.mnh.0000222690.53970.ca","article-title":"Cilium-generated signaling: A cellular GPS?","volume":"15","author":"Benzing","year":"2006","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"R30-15-20230410","first-page":"2398A","article-title":"The cytoplasmic tail of fibrocystin\/polyduction contains a ciliary targeting sequence","volume":"16","author":"Li","year":"2005","journal-title":"Mol Biol Cell"},{"key":"R31-15-20230410","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1038\/sj.emboj.7600885","article-title":"Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia","volume":"24","author":"Schermer","year":"2005","journal-title":"EMBO J"},{"key":"R32-15-20230410","doi-asserted-by":"crossref","first-page":"F930","DOI":"10.1152\/ajprenal.00285.2006","article-title":"Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling","volume":"292","author":"Xu","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"R33-15-20230410","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1091\/mbc.e04-06-0457","article-title":"SMP-1, a member of a new family of small myristoylated proteins in kinetoplastid parasites, is targeted to the flagellum membrane in Leishmania","volume":"15","author":"Tull","year":"2004","journal-title":"Mol Biol Cell"},{"key":"R34-15-20230410","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1083\/jcb.151.7.1369","article-title":"Identification of an outer segment targeting signal in the COOH terminus of rhodopsin using transgenic Xenopus laevis","volume":"151","author":"Tam","year":"2000","journal-title":"J Cell Biol"},{"key":"R35-15-20230410","doi-asserted-by":"crossref","first-page":"24115","DOI":"10.1074\/jbc.M001876200","article-title":"A possible role for caveolin as a signaling organizer in olfactory sensory membranes","volume":"275","author":"Schreiber","year":"2000","journal-title":"J Biol Chem"},{"key":"R36-15-20230410","first-page":"F602","article-title":"Polycystin expression is temporally and spatially regulated during renal development","volume":"272","author":"van Adelsberg","year":"1997","journal-title":"Am J Physiol"},{"key":"R37-15-20230410","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0002-9440(10)64919-X","article-title":"Expression of PKD1 and PKD2 transcripts and proteins in human embryo and during normal kidney development","volume":"160","author":"Chauvet","year":"2002","journal-title":"Am J Pathol"},{"key":"R38-15-20230410","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/j.1523-1755.2004.00844.x","article-title":"Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium and cytoplasm","volume":"66","author":"Menezes","year":"2004","journal-title":"Kidney Int"},{"key":"R39-15-20230410","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1006\/jmbi.2002.5425","article-title":"N-terminal N-myristoylation of proteins: Refinement of the sequence motif and its taxon-specific differences","volume":"317","author":"Maurer-Stroh","year":"2002","journal-title":"J Mol Biol"},{"key":"R40-15-20230410","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0955-0674(00)00238-6","article-title":"Roles of lipid rafts in membrane transport","volume":"13","author":"Ikonen","year":"2001","journal-title":"Curr Opin Cell Biol"},{"key":"R41-15-20230410","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/09687860500466857","article-title":"Visualizing membrane microdomains by Laurdan 2-photon microscopy","volume":"23","author":"Gaus","year":"2006","journal-title":"Mol Membr Biol"},{"key":"R42-15-20230410","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/cbic.200700003","article-title":"A two-photon fluorescent probe for lipid raft imaging: C-laurdan","volume":"8","author":"Kim","year":"2007","journal-title":"Chembiochem"},{"key":"R43-15-20230410","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1529\/biophysj.106.096586","article-title":"Diffusion analysis within single nanometric apertures reveals the ultrafine cell membrane organization","volume":"92","author":"Wenger","year":"2007","journal-title":"Biophys J"},{"key":"R44-15-20230410","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1371\/journal.pgen.0010053","article-title":"Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function","volume":"1","author":"Haycraft","year":"2005","journal-title":"PLoS Genet"},{"key":"R45-15-20230410","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1042\/BJ20050645","article-title":"A polycystin multiprotein complex constitutes a cholesterol-containing signalling microdomain in human kidney epithelia","volume":"392","author":"Roitbak","year":"2005","journal-title":"Biochem J"},{"key":"R46-15-20230410","first-page":"581A","article-title":"Lipid raft mediates JAK2 activation by polycystin-1 [Abstract]","volume":"16","author":"Bhunia","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"R47-15-20230410","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.1143609","article-title":"The Chlamydomonas genome reveals the evolution of key animal and plant functions","volume":"318","author":"Merchant","year":"2007","journal-title":"Science"},{"key":"R48-15-20230410","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/ng0906-961","article-title":"The ciliary proteome database: An integrated community resource for the genetic and functional dissection of cilia","volume":"38","author":"Gherman","year":"2006","journal-title":"Nat Genet"},{"key":"R49-15-20230410","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1681\/ASN.V11101837","article-title":"Development of autosomal recessive polycystic kidney disease in BALB\/c-cpk\/cpk mice","volume":"11","author":"Ricker","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"R50-15-20230410","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0076-6879(93)25025-W","article-title":"Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts","volume":"225","author":"Wilkinson","year":"1993","journal-title":"Methods Enzymol"},{"key":"R51-15-20230410","first-page":"F347","article-title":"Electrogenic sodium absorption and chloride secretion by an inner medullary collecting duct cell line (mIMCD-K2)","volume":"268","author":"Kizer","year":"1995","journal-title":"Am J Physiol"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-200912000-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:31:52Z","timestamp":1786131112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-200912000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2009020188","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}