{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:30:30Z","timestamp":1791286230794,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1681\/asn.2009060603","type":"journal-article","created":{"date-parts":[[2009,12,3]],"date-time":"2009-12-03T22:44:01Z","timestamp":1259880241000},"page":"295-302","source":"Crossref","is-referenced-by-count":132,"title":["Loss of Oriented Cell Division Does not Initiate Cyst Formation"],"prefix":"10.1681","volume":"21","author":[{"given":"Saori","family":"Nishio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Rachel","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Somlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20230410","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.med.60.101707.125712","article-title":"Polycystic kidney disease","volume":"60","author":"Harris","year":"2009","journal-title":"Annu Rev Med"},{"key":"R2-15-20230410","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1091\/mbc.12.3.589","article-title":"Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia","volume":"12","author":"Taulman","year":"2001","journal-title":"Mol Biol Cell"},{"key":"R3-15-20230410","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1242\/dev.01240","article-title":"A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney","volume":"131","author":"Sun","year":"2004","journal-title":"Development"},{"key":"R4-15-20230410","first-page":"533","article-title":"Cystin, a novel cilial-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease","volume":"109","author":"Hou","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R5-15-20230410","doi-asserted-by":"crossref","first-page":"5286","DOI":"10.1073\/pnas.0836980100","article-title":"Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease","volume":"100","author":"Lin","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R6-15-20230410","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1086\/368295","article-title":"Mutations in PRKCSH cause isolated autosomal dominant polycystic liver disease","volume":"72","author":"Li","year":"2003","journal-title":"Am J Hum Genet"},{"key":"R7-15-20230410","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/ng1357","article-title":"Mutations in SEC63 cause autosomal dominant polycystic liver disease","volume":"36","author":"Davila","year":"2004","journal-title":"Nat Genet"},{"key":"R8-15-20230410","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.devcel.2008.03.010","article-title":"Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways","volume":"14","author":"Kishimoto","year":"2008","journal-title":"Dev Cell"},{"key":"R9-15-20230410","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.genet.42.110807.091432","article-title":"Planar cell polarity signaling: From fly development to human disease","volume":"42","author":"Simons","year":"2008","journal-title":"Annu Rev Genet"},{"key":"R10-15-20230410","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/ng1552","article-title":"Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways","volume":"37","author":"Simons","year":"2005","journal-title":"Nat Genet"},{"key":"R11-15-20230410","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/ng0505-455","article-title":"Linking cilia to Wnts","volume":"37","author":"Germino","year":"2005","journal-title":"Nat Genet"},{"key":"R12-15-20230410","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nature02796","article-title":"Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation","volume":"430","author":"Gong","year":"2004","journal-title":"Nature"},{"key":"R13-15-20230410","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng1701","article-title":"Defective planar cell polarity in polycystic kidney disease","volume":"38","author":"Fischer","year":"2006","journal-title":"Nat Genet"},{"key":"R14-15-20230410","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1093\/hmg\/ddn045","article-title":"Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia","volume":"17","author":"Patel","year":"2008","journal-title":"Hum Mol Genet"},{"key":"R15-15-20230410","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/ng.179","article-title":"Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease","volume":"40","author":"Saburi","year":"2008","journal-title":"Nat Genet"},{"key":"R16-15-20230410","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2353\/ajpath.2008.070381","article-title":"Biliary and pancreatic dysgenesis in mice harboring a mutation in Pkhd1","volume":"172","author":"Gallagher","year":"2008","journal-title":"Am J Pathol"},{"key":"R17-15-20230410","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00467-007-0735-4","article-title":"Kidney cysts, pancreatic cysts, and biliary disease in a mouse model of autosomal recessive polycystic kidney disease","volume":"23","author":"Williams","year":"2008","journal-title":"Pediatr Nephrol"},{"key":"R18-15-20230410","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1093\/hmg\/ddn039","article-title":"Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1","volume":"17","author":"Shibazaki","year":"2008","journal-title":"Hum Mol Genet"},{"key":"R19-15-20230410","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/gene.10117","article-title":"Temporal Cre-mediated recombination exclusively in endothelial cells using Tie2 regulatory elements","volume":"33","author":"Forde","year":"2002","journal-title":"Genesis"},{"key":"R20-15-20230410","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/gene.10021","article-title":"A Cre recombinase transgene with mosaic, widespread tamoxifen-inducible action","volume":"32","author":"Guo","year":"2002","journal-title":"Genesis"},{"key":"R21-15-20230410","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/nm1675","article-title":"A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1","volume":"13","author":"Piontek","year":"2007","journal-title":"Nat Med"},{"key":"R22-15-20230410","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/ng.400","article-title":"Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis","volume":"41","author":"Karner","year":"2009","journal-title":"Nat Genet"},{"key":"R23-15-20230410","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1093\/hmg\/ddm141","article-title":"Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway","volume":"16","author":"Garcia-Gonzalez","year":"2007","journal-title":"Hum Mol Genet"},{"key":"R24-15-20230410","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature04375","article-title":"Planar cell polarity signalling couples cell division and morphogenesis during neurulation","volume":"439","author":"Ciruna","year":"2006","journal-title":"Nature"},{"key":"R25-15-20230410","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0092-8674(00)81793-6","article-title":"The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I","volume":"87","author":"Qian","year":"1996","journal-title":"Cell"},{"key":"R26-15-20230410","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/hep.20655","article-title":"A mouse model for cystic biliary dysgenesis in autosomal recessive polycystic kidney disease (ARPKD)","volume":"41","author":"Moser","year":"2005","journal-title":"Hepatology"},{"key":"R27-15-20230410","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/sj.ki.5002294","article-title":"A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation","volume":"72","author":"Woollard","year":"2007","journal-title":"Kidney Int"},{"key":"R28-15-20230410","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1242\/dev.022087","article-title":"A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney","volume":"136","author":"Yu","year":"2009","journal-title":"Development"},{"key":"R29-15-20230410","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1093\/hmg\/ddm299","article-title":"Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice","volume":"16","author":"Lantinga-van Leeuwen","year":"2007","journal-title":"Hum Mol Genet"},{"key":"R30-15-20230410","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1172\/JCI22850","article-title":"Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation","volume":"115","author":"Nishio","year":"2005","journal-title":"J Clin Invest"},{"key":"R31-15-20230410","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1093\/hmg\/ddp147","article-title":"Renal injury is a third hit promoting rapid development of adult polycystic kidney disease","volume":"18","author":"Takakura","year":"2009","journal-title":"Hum Mol Genet"},{"key":"R32-15-20230410","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1093\/hmg\/ddp190","article-title":"Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways","volume":"18","author":"Happe","year":"2009","journal-title":"Hum Mol Genet"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201002000-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:32:02Z","timestamp":1786131122000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201002000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2009060603","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}