{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:09:17Z","timestamp":1786133357640,"version":"build-2736575974"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1681\/asn.2009060631","type":"journal-article","created":{"date-parts":[[2009,10,22]],"date-time":"2009-10-22T22:24:43Z","timestamp":1256250283000},"page":"2651-2660","source":"Crossref","is-referenced-by-count":116,"title":["Left Ventricular Geometry Predicts Cardiovascular Outcomes Associated with Anemia Correction in CKD"],"prefix":"10.1681","volume":"20","author":[{"given":"Kai-Uwe","family":"Eckardt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Scherhag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain C.","family":"Macdougall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Tsakiris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Clyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Locatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Zaug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans U.","family":"Burger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman B.","family":"Drueke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-23-20230410","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/CIRCULATIONAHA.106.678342","article-title":"Chronic kidney disease: Effects on the cardiovascular system","volume":"116","author":"Schiffrin","year":"2007","journal-title":"Circulation"},{"key":"R2-23-20230410","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/ki.1995.22","article-title":"Clinical and echocardiographic disease in patients starting end-stage renal disease therapy","volume":"47","author":"Foley","year":"1995","journal-title":"Kidney Int"},{"key":"R3-23-20230410","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0272-6386(96)90357-1","article-title":"Prevalent left ventricular hypertrophy in the predialysis population: Identifying opportunities for intervention","volume":"27","author":"Levin","year":"1996","journal-title":"Am J Kidney Dis"},{"key":"R4-23-20230410","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1097\/HJH.0b013e3283220ecd","article-title":"Left ventricular hypertrophy and geometry in hypertensive patients with chronic kidney disease","volume":"27","author":"Nardi","year":"2009","journal-title":"J Hypertens"},{"key":"R5-23-20230410","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/ndt\/11.7.1277","article-title":"Outcome and risk factors for left ventricular disorders in chronic uraemia","volume":"11","author":"Parfrey","year":"1996","journal-title":"Nephrol Dial Transplant"},{"key":"R6-23-20230410","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1681\/ASN.V12122759","article-title":"Alterations of left ventricular hypertrophy in and survival of patients receiving hemodialysis: Follow-up of an interventional study","volume":"12","author":"London","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"R7-23-20230410","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1093\/ndt\/gfm417","article-title":"Predictors of cardiovascular events in patients with end-stage renal disease: An analysis from the Fosinopril in dialysis study","volume":"22","author":"Kessler","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"R8-23-20230410","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/ki.1989.192","article-title":"Impact of left ventricular hypertrophy on survival in end-stage renal disease","volume":"36","author":"Silberberg","year":"1989","journal-title":"Kidney Int"},{"key":"R9-23-20230410","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0272-6386(96)90130-4","article-title":"The impact of anemia on cardiomyopathy, morbidity, and mortality in end-stage renal disease","volume":"28","author":"Foley","year":"1996","journal-title":"Am J Kidney Dis"},{"key":"R10-23-20230410","first-page":"1","article-title":"Regression of left ventricular hypertrophy in dialysis patients following correction of anemia with recombinant human erythropoietin","volume":"6","author":"Silberberg","year":"1990","journal-title":"Can J Cardiol"},{"key":"R11-23-20230410","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0272-6386(99)70118-6","article-title":"Left ventricular mass index increase in early renal disease: impact of decline in hemoglobin","volume":"34","author":"Levin","year":"1999","journal-title":"Am J Kidney Dis"},{"key":"R12-23-20230410","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/CIRCULATIONAHA.105.582577","article-title":"Clinical correlates and consequences of anemia in a broad spectrum of patients with heart failure: Results of the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) Program","volume":"113","author":"O'Meara","year":"2006","journal-title":"Circulation"},{"key":"R13-23-20230410","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1681\/ASN.2004070597","article-title":"Effects of anemia and left ventricular hypertrophy on cardiovascular disease in patients with chronic kidney disease","volume":"16","author":"Weiner","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"R14-23-20230410","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/ndt\/14.5.1317","article-title":"Cardiovascular consequences of renal anaemia and erythropoietin therapy","volume":"14","author":"Eckardt","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"R15-23-20230410","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/ki.1989.274","article-title":"Vascular changes in hemodialysis patients in response to recombinant human erythropoietin","volume":"36","author":"London","year":"1989","journal-title":"Kidney Int"},{"key":"R16-23-20230410","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0140-6736(90)90733-L","article-title":"Long-term cardiorespiratory effects of amelioration of renal anaemia by erythropoietin","volume":"335","author":"Macdougall","year":"1990","journal-title":"Lancet"},{"key":"R17-23-20230410","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1525-1594.1993.tb03179.x","article-title":"Analysis of heart morphology and function following erythropoietin treatment of anemic dialysis patients","volume":"17","author":"Sikole","year":"1993","journal-title":"Artif Organs"},{"key":"R18-23-20230410","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0272-6386(97)90335-8","article-title":"Cardiovascular effects of recombinant human erythropoietin in predialysis patients","volume":"29","author":"Portol\u00e9s","year":"1997","journal-title":"Am J Kidney Dis"},{"key":"R19-23-20230410","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1046\/j.1523-1755.2000.00289.x","article-title":"Effect of hemoglobin levels in hemodialysis patients with asymptomatic cardiomyopathy","volume":"58","author":"Foley","year":"2000","journal-title":"Kidney Int"},{"key":"R20-23-20230410","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/01.ASN.0000102471.89084.8B","article-title":"Effects of early and late intervention with epoetin alpha on left ventricular mass among patients with chronic kidney disease (stage 3 or 4): Results of a randomised clinical trial","volume":"15","author":"Roger","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"R21-23-20230410","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1053\/j.ajkd.2005.08.007","article-title":"Canadian randomized trial of hemoglobin maintenance to prevent or delay left ventricular mass growth in patients with CKD","volume":"46","author":"Levin","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"R22-23-20230410","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1681\/ASN.2004121039","article-title":"Double-blind comparison of full and partial anaemia correction in incident hemodialysis patients without symptomatic heart disease","volume":"16","author":"Parfrey","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"R23-23-20230410","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1056\/NEJMoa062276","article-title":"Normalization of hemoglobin level in patients with chronic kidney disease and anemia","volume":"355","author":"Dr\u00fceke","year":"2006","journal-title":"N Engl J Med"},{"key":"R24-23-20230410","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/ndt\/gfl483","article-title":"Is early treatment of anaemia with epoetin alfa beneficial to predialysis chronic kidney disease patients? Results of a multicentre, open-label, prospective, randomised, comparative group trial","volume":"22","author":"Macdougall","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"R25-23-20230410","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1053\/j.ajkd.2006.11.032","article-title":"Anemia Correction in Diabetes Study Investigators: Target level for hemoglobin correction in patients with diabetes and CKD: Primary results of the Anemia Correction in Diabetes (ACORD) Study [erratum appears in Am J Kidney Dis 49: 562, 2007]","volume":"49","author":"Ritz","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"R26-23-20230410","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1056\/NEJMoa065485","article-title":"Correction of anemia with epoetin alfa in chronic kidney disease","volume":"355","author":"Singh","year":"2006","journal-title":"N Engl J Med"},{"key":"R27-23-20230410","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1056\/NEJM199808273390903","article-title":"The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin","volume":"339","author":"Besarab","year":"1998","journal-title":"N Engl J Med"},{"key":"R28-23-20230410","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1681\/ASN.V5122024","article-title":"The prognostic importance of left ventricular geometry in uremic cardiomyopathy","volume":"5","author":"Foley","year":"1995","journal-title":"J Am Soc Nephrol"},{"key":"R29-23-20230410","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2215\/CJN.02730608","article-title":"Erythropoietin therapy and left ventricular mass index in CKD and ESRD patients: A meta-analysis","volume":"4","author":"Parfrey","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"R30-23-20230410","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1056\/NEJM199910213411706","article-title":"Signaling pathways for cardiac hypertrophy and failure","volume":"341","author":"Hunter","year":"1999","journal-title":"N Engl J Med"},{"key":"R31-23-20230410","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.hfc.2005.03.006","article-title":"Mechanisms of cardiac hypertrophy","volume":"1","author":"Selvetella","year":"2005","journal-title":"Heart Fail Clin"},{"key":"R32-23-20230410","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/ncpneph0441","article-title":"How important is echocardiography for risk stratification in follow-up of patients with chronic kidney disease?","volume":"3","author":"Zoccali","year":"2007","journal-title":"Nat Clin Pract Nephrol"},{"key":"R33-23-20230410","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1093\/ndt\/gfm224","article-title":"Are we overestimating left ventricular abnormalities in end-stage renal disease?","volume":"22","author":"Mark","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"R34-23-20230410","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1097\/00007890-200008270-00006","article-title":"Long-term changes in left ventricular hypertrophy after renal transplantation","volume":"70","author":"Rigatto","year":"2000","journal-title":"Transplantation"},{"key":"R35-23-20230410","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1111\/j.1600-6143.2008.02407.x","article-title":"Severe left ventricular systolic dysfunction may reverse with renal transplantation: Uremic cardiomyopathy and cardiorenal syndrome","volume":"8","author":"Zolty","year":"2008","journal-title":"Am J Transplant"},{"key":"R36-23-20230410","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1113\/jphysiol.2006.122689","article-title":"Erythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volume","volume":"578","author":"Lundby","year":"2007","journal-title":"J Physiol"},{"key":"R37-23-20230410","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0272-6386(12)80056-4","article-title":"Body fluid spaces and blood pressure in hemodialysis patients during amelioration of anemia with erythropoietin","volume":"16","author":"Abraham","year":"1990","journal-title":"Am J Kidney Dis"},{"key":"R38-23-20230410","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1681\/ASN.V9197","article-title":"Hemodynamic and hormonal changes during erythropoietin therapy in hemodialysis patients","volume":"9","author":"Lebel","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"R39-23-20230410","first-page":"621","article-title":"Influence of blood volume on the blood pressure of predialysis and peritoneal dialysis patients treated with erythropoietin","volume":"8","author":"Anastassiades","year":"1993","journal-title":"Nephrol Dial Transplant"},{"key":"R40-23-20230410","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/pgmj.67.783.9","article-title":"The use of erythropoietin in renal failure","volume":"67","author":"Macdougall","year":"1991","journal-title":"Postgrad Med J"},{"key":"R41-23-20230410","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/ki.2008.295","article-title":"Secondary analysis of the CHOIR trial epoetin-alpha dose and achieved hemoglobin outcomes","volume":"74","author":"Szczech","year":"2008","journal-title":"Kidney Int"},{"key":"R42-23-20230410","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ndt\/16.suppl_2.16","article-title":"The CREATE trial: Building the evidence","volume":"16","author":"Eckardt","year":"2001","journal-title":"Nephrol Dial Transplant"},{"key":"R43-23-20230410","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0894-7317(89)80014-8","article-title":"Recommendations for quantitation of the left ventricle by two-dimensional echocardiography","volume":"2","author":"Schiller","year":"1989","journal-title":"J Am Soc Echocardiogr"},{"key":"R44-23-20230410","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/0002-9149(92)90213-I","article-title":"A new classification of left ventricular geometry in patients with cardiac disease based on M-mode echocardiography","volume":"70","author":"Huwez","year":"1992","journal-title":"Am J Cardiol"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-200912000-00023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:32:47Z","timestamp":1786131167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-200912000-00023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2009060631","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}