{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:10:13Z","timestamp":1788199813251,"version":"build-2803163510"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1681\/asn.2009070725","type":"journal-article","created":{"date-parts":[[2009,12,3]],"date-time":"2009-12-03T22:44:01Z","timestamp":1259880241000},"page":"337-344","source":"Crossref","is-referenced-by-count":144,"title":["Uromodulin Levels Associate with a Common UMOD Variant and Risk for Incident CKD"],"prefix":"10.1681","volume":"21","author":[{"given":"Anna","family":"K\u00f6ttgen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Jen","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Van Eyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelia J.","family":"Benjamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Dehghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Glazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.H. Linda","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara B.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilmundur","family":"Gudnason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Shlipak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Coresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline S.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20230410","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1471-2458-8-117","article-title":"Prevalence of chronic kidney disease in population-based studies: systematic review","volume":"8","author":"Zhang","year":"2008","journal-title":"BMC Public Health"},{"key":"R2-19-20230410","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1001\/jama.298.17.2038","article-title":"Prevalence of chronic kidney disease in the United States","volume":"298","author":"Coresh","year":"2007","journal-title":"JAMA"},{"key":"R3-19-20230410","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/fampra\/cmi026","article-title":"Identifying patients with chronic kidney disease from general practice computer records","volume":"22","author":"de Lusignan","year":"2005","journal-title":"Fam Pract"},{"key":"R4-19-20230410","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1161\/01.HYP.0000102971.85504.7c","article-title":"Kidney disease as a risk factor for development of cardiovascular disease: A statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention","volume":"42","author":"Sarnak","year":"2003","journal-title":"Hypertension"},{"key":"R5-19-20230410","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1097\/01.ASN.0000123691.46138.E2","article-title":"Chronic kidney disease as a risk factor for cardiovascular disease and all-cause mortality: A pooled analysis of community-based studies","volume":"15","author":"Weiner","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"R6-19-20230410","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1525-139X.2007.00282.x","article-title":"Familial clustering of chronic kidney disease","volume":"20","author":"Satko","year":"2007","journal-title":"Semin Dial"},{"key":"R7-19-20230410","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ng.377","article-title":"Multiple loci associated with indices of renal function and chronic kidney disease","volume":"41","author":"K\u00f6ttgen","year":"2009","journal-title":"Nat Genet"},{"key":"R8-19-20230410","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1136\/jmg.39.12.882","article-title":"Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy","volume":"39","author":"Hart","year":"2002","journal-title":"J Med Genet"},{"key":"R9-19-20230410","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0272-6386(03)00829-1","article-title":"Tamm-Horsfall glycoprotein: Biology and clinical relevance","volume":"42","author":"Serafini-Cessi","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"R10-19-20230410","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3181\/00379727-74-17825","article-title":"Characterization and separation of an inhibitor of viral hemagglutination present in urine","volume":"74","author":"Tamm","year":"1950","journal-title":"Proc Soc Exp Biol Med"},{"key":"R11-19-20230410","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1126\/science.2409603","article-title":"Uromodulin: A unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women","volume":"229","author":"Muchmore","year":"1985","journal-title":"Science"},{"key":"R12-19-20230410","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1093\/hmg\/ddg353","article-title":"Allelism of MCKD, FJHN and GCKD caused by impairment of uromodulin export dynamics","volume":"12","author":"Rampoldi","year":"2003","journal-title":"Hum Mol Genet"},{"key":"R13-19-20230410","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1097\/01.ASN.0000092147.83480.B5","article-title":"A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin","volume":"14","author":"Dahan","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"R14-19-20230410","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/j.1523-1755.2004.00845.x","article-title":"Mutations in the uromodulin gene decrease urinary excretion of Tamm-Horsfall protein","volume":"66","author":"Bleyer","year":"2004","journal-title":"Kidney Int"},{"key":"R15-19-20230410","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1042\/cs0680529","article-title":"Human Tamm-Horsfall glycoprotein: Urinary and plasma levels in normal subjects and patients with renal disease determined by a fully validated radioimmunoassay","volume":"68","author":"Thornley","year":"1985","journal-title":"Clin Sci (Lond"},{"key":"R16-19-20230410","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1111\/j.1600-0854.2006.00481.x","article-title":"Defective intracellular trafficking of uromodulin mutant isoforms","volume":"7","author":"Bernascone","year":"2006","journal-title":"Traffic"},{"key":"R17-19-20230410","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/sj.ki.5001728","article-title":"Alterations of uromodulin biology: A common denominator of the genetically heterogeneous FJHN\/MCKD syndrome","volume":"70","author":"Vylet'al","year":"2006","journal-title":"Kidney Int"},{"key":"R18-19-20230410","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1093\/hmg\/ddp235","article-title":"Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum","volume":"18","author":"Williams","year":"2009","journal-title":"Hum Mol Genet"},{"key":"R19-19-20230410","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.4049\/jimmunol.158.7.3449","article-title":"Uromodulin and Tamm-Horsfall protein induce human monocytes to secrete TNF and express tissue factor","volume":"158","author":"Su","year":"1997","journal-title":"J Immunol"},{"key":"R20-19-20230410","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/abbi.2000.2265","article-title":"Conditions for solubilization of Tamm-Horsfall protein\/uromodulin in human urine and establishment of a sensitive and accurate enzyme-linked immunosorbent assay (ELISA) method","volume":"388","author":"Kobayashi","year":"2001","journal-title":"Arch Biochem Biophys"},{"key":"R21-19-20230410","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/cs0620021","article-title":"Factors affecting excretion of human urinary Tamm-Horsfall glycoprotein","volume":"62","author":"Lynn","year":"1982","journal-title":"Clin Sci (Lond"},{"key":"R22-19-20230410","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1042\/bj2060461","article-title":"An improved radioimmunoassay for urinary Tamm-Horsfall glycoprotein: Investigation and resolution of factors affecting its quantification","volume":"206","author":"Dawnay","year":"1982","journal-title":"Biochem J"},{"key":"R23-19-20230410","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/oxfordjournals.aje.a112813","article-title":"An investigation of coronary heart disease in families. The Framingham Offspring Study","volume":"110","author":"Kannel","year":"1979","journal-title":"Am J Epidemiol"},{"key":"R26-19-20230410","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of Diet in Renal Disease Study Group","volume":"130","author":"Levey","year":"1999","journal-title":"Ann Intern Med"},{"key":"R27-19-20230410","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1001\/jama.291.7.844","article-title":"Predictors of new-onset kidney disease in a community-based population","volume":"291","author":"Fox","year":"2004","journal-title":"JAMA"},{"key":"R28-19-20230410","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1053\/ajkd.2002.32765","article-title":"Calibration and random variation of the serum creatinine assay as critical elements of using equations to estimate glomerular filtration rate","volume":"39","author":"Coresh","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"R29-19-20230410","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1002\/pmic.200402048","article-title":"A robust, streamlined, and reproducible method for proteomic analysis of serum by delipidation, albumin and IgG depletion, and two-dimensional gel electrophoresis","volume":"5","author":"Fu","year":"2005","journal-title":"Proteomics"},{"key":"R30-19-20230410","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.yjmcc.2007.08.011","article-title":"Proteomic alterations in heat shock protein 27 and identification of phosphoproteins in ascending aortic aneurysm associated with bicuspid and tricuspid aortic valve","volume":"43","author":"Matt","year":"2007","journal-title":"J Mol Cell Cardiol"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201002000-00019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:33:03Z","timestamp":1786131183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201002000-00019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2009070725","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1405956.881054","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1405956.1503054","asserted-by":"object"}]},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}