{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:12:35Z","timestamp":1792224755114,"version":"4.4.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1681\/asn.2009080857","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T22:01:59Z","timestamp":1267135319000},"page":"705-712","source":"Crossref","is-referenced-by-count":302,"title":["Oral Tolvaptan Is Safe and Effective in Chronic Hyponatremia"],"prefix":"10.1681","volume":"21","author":[{"given":"Tomas","family":"Berl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Quittnat-Pelletier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph G.","family":"Verbalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Schrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Bichet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank S.","family":"Czerwiec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-23-20230509","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1038\/sj.ki.5000432","article-title":"Vasopressin receptor antagonists.","volume":"69","author":"Greenberg","year":"2006","journal-title":"Kidney Int"},{"key":"R2-23-20230509","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/MAJ.0b013e31817b8148","article-title":"Efficacy and safety of oral conivaptan, a vasopressin-receptor antagonist, evaluated in a randomized, controlled trial in patients with euvolemic or hypervolemic hyponatremia.","volume":"337","author":"Annane","year":"2009","journal-title":"Am J Med Sci"},{"key":"R3-23-20230509","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S0002-9343(01)00678-7","article-title":"Long-term treatment of patients with inappropriate secretion of antidiuretic hormone by the vasopressin receptor antagonist conivaptan, urea, or furosemide.","volume":"110","author":"Decaux","year":"2001","journal-title":"Am J Med"},{"key":"R4-23-20230509","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1210\/jc.2005-2287","article-title":"Efficacy and safety of oral conivaptan: A V1A\/V2 vasopressin receptor antagonist, assessed in a randomized, placebo-controlled trial in patients with euvolemic or hypervolemic hyponatremia.","volume":"91","author":"Ghali","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"R5-23-20230509","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/hep.22293","article-title":"Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: A randomized trial.","volume":"48","author":"Gines","year":"2008","journal-title":"Hepatology"},{"key":"R6-23-20230509","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.2215\/CJN.00160106","article-title":"Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist.","volume":"1","author":"Soupart","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"key":"R7-23-20230509","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.amjcard.2005.10.050","article-title":"Vasopressin V(2) receptor blockade with tolvaptan versus fluid restriction in the treatment of hyponatremia.","volume":"97","author":"Gheorghiade","year":"2006","journal-title":"Am J Cardiol"},{"key":"R8-23-20230509","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1056\/NEJMoa065181","article-title":"Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia.","volume":"355","author":"Schrier","year":"2006","journal-title":"N Engl J Med"},{"key":"R9-23-20230509","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1053\/jhep.2003.50021","article-title":"A vasopressin receptor antagonist (VPA-985) improves serum sodium concentration in patients with hyponatremia: A multicenter, randomized, placebo-controlled trial.","volume":"37","author":"Wong","year":"2003","journal-title":"Hepatology"},{"key":"R10-23-20230509","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1001\/jama.297.12.1319","article-title":"Effects of oral tolvaptan in patients hospitalized for worsening heart failure: The EVEREST Outcome Trial.","volume":"297","author":"Konstam","year":"2007","journal-title":"JAMA"},{"key":"R11-23-20230509","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1159\/000106456","article-title":"Assessment of the efficacy and safety of intravenous conivaptan in euvolemic and hypervolemic hyponatremia.","volume":"27","author":"Zeltser","year":"2007","journal-title":"Am J Nephrol"},{"key":"R12-23-20230509","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0889-8529(03)00004-5","article-title":"Evaluation and management of hypo-osmolality in hospitalized patients.","volume":"32","author":"Janicic","year":"2003","journal-title":"Endocrinol Metab Clin North Am"},{"key":"R13-23-20230509","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cccn.2003.08.001","article-title":"Age and gender as risk factors for hyponatremia and hypernatremia.","volume":"337","author":"Hawkins","year":"2003","journal-title":"Clin Chim Acta"},{"key":"R14-23-20230509","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5414\/CNP65028","article-title":"Incidence and factors predictive of acute renal failure in patients with advanced liver cirrhosis.","volume":"65","author":"Wu","year":"2006","journal-title":"Clin Nephrol"},{"key":"R15-23-20230509","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1161\/01.CIR.0000165065.82609.3D","article-title":"Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure: Results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study.","volume":"111","author":"Klein","year":"2005","journal-title":"Circulation"},{"key":"R16-23-20230509","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/ana.20788","article-title":"Neurological impact of vasopressin dysregulation and hyponatremia.","volume":"59","author":"Bhardwaj","year":"2006","journal-title":"Ann Neurol"},{"key":"R17-23-20230509","doi-asserted-by":"crossref","first-page":"71.e1","DOI":"10.1016\/j.amjmed.2005.09.026","article-title":"Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits.","volume":"119","author":"Renneboog","year":"2006","journal-title":"Am J Med"},{"key":"R18-23-20230509","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/qjmed\/hcn061","article-title":"Mild hyponatremia and risk of fracture in the ambulatory elderly.","volume":"101","author":"Gankam Kengne","year":"2008","journal-title":"QJM"},{"key":"R19-23-20230509","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1111\/j.1532-5415.1995.tb06623.x","article-title":"Hyponatremia in a nursing home population.","volume":"43","author":"Miller","year":"1995","journal-title":"J Am Geriatr Soc"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201004000-00023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:32:18Z","timestamp":1786131138000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201004000-00023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2009080857","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.2669956.2333054","asserted-by":"object"}]},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}