{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:49:36Z","timestamp":1790542176760,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1681\/asn.2010040352","type":"journal-article","created":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T13:28:57Z","timestamp":1296653337000},"page":"262-273","source":"Crossref","is-referenced-by-count":70,"title":["The Tuberin\/mTOR Pathway Promotes Apoptosis of Tubular Epithelial Cells in Diabetes"],"prefix":"10.1681","volume":"22","author":[{"given":"Chakradhar","family":"Velagapudi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basant S.","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry","family":"Abboud-Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Simone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna E.","family":"Abboud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samy L.","family":"Habib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-13-20230423","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/jim-50-06-04","article-title":"Taurine prevents apoptosis induced by high ambient glucose in human tubule renal cells","volume":"50","author":"Verzola","year":"2002","journal-title":"J Investig Med"},{"key":"R2-13-20230423","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1096\/fj.02-0130fje","article-title":"High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases","volume":"17","author":"Allen","year":"2003","journal-title":"FASEB J"},{"key":"R3-13-20230423","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1681\/ASN.2007010074","article-title":"Overexpression of angiotensinogen increases tubular apoptosis in diabetes","volume":"19","author":"Liu","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"R4-13-20230423","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1097\/01.ASN.0000093370.20008.BC","article-title":"Oxidative stress mediates apoptotic changes induced by hyperglycemia in human tubular kidney cells","volume":"15","author":"Verzola","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"R5-13-20230423","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1046\/j.1523-1755.2001.0590051695.x","article-title":"High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress and TGF-\u03b21","volume":"59","author":"Park","year":"2001","journal-title":"Kidney Int"},{"key":"R6-13-20230423","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.2337\/db07-1579","article-title":"Mechanism of oxidative DNA damage in diabetes","volume":"57","author":"Simone","year":"2008","journal-title":"Diabetes"},{"key":"R7-13-20230423","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S1097-2765(03)00220-X","article-title":"Insulin activation of Rheb, a mediator of mTOR\/S6K\/4E-BP signaling is inhibited by TSC1 and TSC2","volume":"11","author":"Garami","year":"2003","journal-title":"Mol Cell"},{"key":"R8-13-20230423","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/ncb996","article-title":"Rheb promotes cell growth as a component of the insulin\/TOR signaling network","volume":"5","author":"Saucedo","year":"2003","journal-title":"Nat Cell Biol"},{"key":"R9-13-20230423","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0960-9822(03)00506-2","article-title":"Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb","volume":"13","author":"Tee","year":"2003","journal-title":"Curr Biol"},{"key":"R10-13-20230423","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ncb999","article-title":"Rheb is a direct target of the tuberous sclerosis tumor suppressor proteins","volume":"5","author":"Zhang","year":"2003","journal-title":"Nat Cell Biol"},{"key":"R11-13-20230423","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/toxsci\/kfi310","article-title":"Tsc2 expression increases the susceptibility of renal tumor cells to apoptosis","volume":"88","author":"Kolb","year":"2005","journal-title":"Toxicol Sci"},{"key":"R12-13-20230423","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.1038\/sj.onc.1209660","article-title":"Tuberin activates the proapoptotic molecule BAD","volume":"25","author":"Freilinger","year":"2006","journal-title":"Oncogene"},{"key":"R13-13-20230423","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1006\/excr.1999.4683","article-title":"Ribosomal S6 kinase signaling and the control of translation","volume":"253","author":"Dufner","year":"1999","journal-title":"Exp Cell Res"},{"key":"R14-13-20230423","doi-asserted-by":"crossref","first-page":"6172","DOI":"10.1038\/sj.onc.1204751","article-title":"Damaged microtubules can inactivate BCL-2 by means of the mTOR kinase","volume":"20","author":"Calastretti","year":"2001","journal-title":"Oncogene"},{"key":"R15-13-20230423","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrc883","article-title":"The BCL2 family: Regulators of the cellular life-or-death switch","volume":"2","author":"Cory","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"R16-13-20230423","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00240-004-0451-5","article-title":"Apoptosis induced by oxalate in human renal tubular epithelial HK2 cells","volume":"33","author":"Jeong","year":"2005","journal-title":"Urol Res"},{"key":"R17-13-20230423","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/376037a0","article-title":"Identification and inhibition of the CED-3 protease necessary for mammalian apoptosis","volume":"376","author":"Nicholson","year":"1995","journal-title":"Nature"},{"key":"R18-13-20230423","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0092-8674(95)90541-3","article-title":"Yama\/CPP32\u03b2, a mammalian homolog of CED-3 is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-Ribose) polymerase","volume":"81","author":"Tewari","year":"1995","journal-title":"Cell"},{"key":"R19-13-20230423","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/bbrc.1998.8257","article-title":"Cellular responses to DNA damage in the absence of poly(ADP-ribose) polymerase","volume":"245","author":"Rhun","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"R20-13-20230423","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/83241","article-title":"Diabetic endothelial dysfunction: The role of poly(ADP-ribose) polymerase activation","volume":"7","author":"Soriano","year":"2001","journal-title":"Nat Med"},{"key":"R21-13-20230423","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1172\/JCI18127","article-title":"Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells","volume":"112","author":"Du","year":"2003","journal-title":"J Clin Invest"},{"key":"R22-13-20230423","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"key":"R23-13-20230423","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1128\/MCB.25.9.3704-3714.2005","article-title":"Caspase-dependent regulation and subcellular redistribution of the transcriptional modulator YY1 during apoptosis","volume":"25","author":"Krippner-Heidenreich","year":"2005","journal-title":"Molec Cell Biol"},{"key":"R24-13-20230423","first-page":"3504","article-title":"A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells","volume":"60","author":"Sekulic","year":"2000","journal-title":"Cancer Res"},{"key":"R25-13-20230423","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0006-2952(02)01263-7","article-title":"A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling","volume":"64","author":"Chen","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"R26-13-20230423","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2119\/molmed.2010.00023","article-title":"Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes","volume":"16","author":"Anita","year":"2010","journal-title":"Mol Med"},{"key":"R27-13-20230423","first-page":"31","article-title":"Rapamycin induces autophagy and exacerbates metabolism associated complications in a mouse model of type 1 diabetes","volume":"48","author":"Zhou","year":"2010","journal-title":"Indian J Exp Biol"},{"key":"R28-13-20230423","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1146\/annurev.biochem.68.1.383","article-title":"Mammmalian caspases: structure, activation, substrates, and functions during apoptosis","volume":"68","author":"Earnshaw","year":"1999","journal-title":"Annu Rev Biochem"},{"key":"R29-13-20230423","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2307\/3576299","article-title":"Poly(ADP-ribose) in the cellular response to DNA damage","volume":"101","author":"Berger","year":"1985","journal-title":"Radiation Res"},{"key":"R30-13-20230423","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/carcin\/24.3.573","article-title":"Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat","volume":"24","author":"Habib","year":"2003","journal-title":"Carcinogenesis"},{"key":"R31-13-20230423","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"R32-13-20230423","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1476-4598-7-10","article-title":"Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors","volume":"7","author":"Habib","year":"2008","journal-title":"Molec Cancer"},{"key":"R33-13-20230423","doi-asserted-by":"crossref","first-page":"F281","DOI":"10.1152\/ajprenal.00370.2007","article-title":"Tuberin regulates the DNA repair enzyme OGG1","volume":"294","author":"Habib","year":"2008","journal-title":"Am J Physiol Renal Physiol"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201102000-00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:33:25Z","timestamp":1786131205000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201102000-00013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2010040352","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}