{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:02:29Z","timestamp":1793325749271,"version":"4.5.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1681\/asn.2011010084","type":"journal-article","created":{"date-parts":[[2011,9,16]],"date-time":"2011-09-16T06:32:36Z","timestamp":1316154756000},"page":"1809-1814","source":"Crossref","is-referenced-by-count":234,"title":["Macrophages Promote Cyst Growth in Polycystic Kidney Disease"],"prefix":"10.1681","volume":"22","author":[{"given":"Anil","family":"Karihaloo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farrukh","family":"Koraishy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C.","family":"Huen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Merrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Caplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Somlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd G.","family":"Cantley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20230423","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1053\/j.ackd.2010.01.002","article-title":"Molecular advances in autosomal dominant polycystic kidney disease","volume":"17","author":"Gallagher","year":"2010","journal-title":"Adv Chronic Kidney Dis"},{"key":"R2-8-20230423","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/ki.2009.128","article-title":"Autosomal dominant polycystic kidney disease: The last 3 years","volume":"76","author":"Torres","year":"2009","journal-title":"Kidney Int"},{"key":"R3-8-20230423","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.med.60.101707.125712","article-title":"Polycystic kidney disease","volume":"60","author":"Harris","year":"2009","journal-title":"Annu Rev Med"},{"key":"R4-8-20230423","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1681\/ASN.2009121224","article-title":"Activator of G protein signaling 3 promotes epithelial cell proliferation in PKD","volume":"21","author":"Nadella","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"R5-8-20230423","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/ki.1991.87","article-title":"Cytokines in fluids from polycystic kidneys","volume":"39","author":"Gardner","year":"1991","journal-title":"Kidney Int"},{"key":"R6-8-20230423","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nm1783","article-title":"A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease","volume":"14","author":"Li","year":"2008","journal-title":"Nat Med"},{"key":"R7-8-20230423","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1097\/01.ASN.0000088720.61783.19","article-title":"Urinary excretion of monocyte chemoattractant protein-1 in autosomal dominant polycystic kidney disease","volume":"14","author":"Zheng","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"R9-8-20230423","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1046\/j.1523-1755.2001.00065.x","article-title":"Increased renal expression of monocyte chemoattractant protein-1 and osteopontin in ADPKD in rats","volume":"60","author":"Cowley","year":"2001","journal-title":"Kidney Int"},{"key":"R10-8-20230423","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/sj.ki.5002627","article-title":"Overexpression of innate immune response genes in a model of recessive polycystic kidney disease","volume":"73","author":"Mrug","year":"2008","journal-title":"Kidney Int"},{"key":"R11-8-20230423","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.semnephrol.2010.03.003","article-title":"Macrophages and immunologic inflammation of the kidney","volume":"30","author":"Duffield","year":"2010","journal-title":"Semin Nephrol"},{"key":"R12-8-20230423","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/MNH.0b013e3283262ab0","article-title":"Advances in the pathogenesis and treatment of polycystic kidney disease","volume":"18","author":"Patel","year":"2009","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"R13-8-20230423","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1093\/hmg\/ddn045","article-title":"Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia","volume":"17","author":"Patel","year":"2008","journal-title":"Hum Mol Genet"},{"key":"R14-8-20230423","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1681\/ASN.2009060615","article-title":"Distinct macrophage phenotypes contribute to kidney injury and repair","volume":"22","author":"Lee","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"R15-8-20230423","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1681\/ASN.2009060603","article-title":"Loss of oriented cell division does not initiate cyst formation","volume":"21","author":"Nishio","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"R16-8-20230423","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/ki.2008.395","article-title":"Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo","volume":"74","author":"Wei","year":"2008","journal-title":"Kidney Int"},{"key":"R17-8-20230423","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1093\/hmg\/ddn039","article-title":"Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1","volume":"17","author":"Shibazaki","year":"2008","journal-title":"Hum Mol Genet"},{"key":"R18-8-20230423","first-page":"1","article-title":"The pathology of human renal cystic disease","volume":"88","author":"Wilson","year":"1995","journal-title":"Curr Top Pathol"},{"key":"R19-8-20230423","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0022-1759(96)00056-7","article-title":"Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine","volume":"193","author":"van Rooijen","year":"1996","journal-title":"J Immunol Methods"},{"key":"R20-8-20230423","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/ndt\/gfk047","article-title":"Macrophages contribute to the initiation of ischaemic acute renal failure in rats","volume":"21","author":"Jo","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"R21-8-20230423","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/269804a0","article-title":"Activated macrophages induce vascular proliferation","volume":"269","author":"Polverini","year":"1977","journal-title":"Nature"},{"key":"R22-8-20230423","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.4049\/jimmunol.0901473","article-title":"Bone marrow Ly6Chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populations","volume":"183","author":"Lin","year":"2009","journal-title":"J Immunol"},{"key":"R23-8-20230423","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.4049\/jimmunol.164.4.2110","article-title":"Activated macrophages direct apoptosis and suppress mitosis of mesangial cells","volume":"164","author":"Duffield","year":"2000","journal-title":"J Immunol"},{"key":"R24-8-20230423","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1182\/blood-2005-05-1902","article-title":"The intracellular domain of CD44 promotes the fusion of macrophages","volume":"107","author":"Cui","year":"2006","journal-title":"Blood"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201110000-00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:34:09Z","timestamp":1786131249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201110000-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2011010084","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}