{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:10:15Z","timestamp":1786133415578,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1681\/asn.2011030256","type":"journal-article","created":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T22:17:04Z","timestamp":1302214624000},"page":"791-793","source":"Crossref","is-referenced-by-count":2,"title":["Tying TAZ and Nek1 into Polycystic Kidney Disease through Polycystin 2 Levels"],"prefix":"10.1681","volume":"22","author":[{"given":"Susan K.","family":"Dutcher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-1-20230423","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1097\/01.ASN.0000028643.17901.42","article-title":"Genetics and pathogenesis of polycystic kidney disease","volume":"13","author":"Igarashi","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R2-1-20230423","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1681\/ASN.2010010127","article-title":"Aberrant regulation of planar cell polarity in polycystic kidney disease","volume":"21","author":"Luyten","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"R3-1-20230423","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1681\/ASN.2006111215","article-title":"Role of primary cilia in the pathogenesis of polycystic kidney disease","volume":"18","author":"Yoder","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"R4-1-20230423","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1681\/ASN.2009060603","article-title":"Loss of oriented cell division does not initiate cyst formation","volume":"21","author":"Nishio","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"R5-1-20230423","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1681\/ASN.2009030271","article-title":"Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin","volume":"20","author":"Kim","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"R6-1-20230423","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1681\/ASN.2010090992","article-title":"Nek1 and TAZ interact to maintain normal levels of polycystin 2","volume":"22","author":"Yim","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"R7-1-20230423","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1110955","article-title":"TAZ, a transcriptional modulator of mesenchymal stem cell differentiation","volume":"309","author":"Hong","year":"2005","journal-title":"Science"},{"key":"R8-1-20230423","doi-asserted-by":"crossref","first-page":"F542","DOI":"10.1152\/ajprenal.00201.2007","article-title":"Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ","volume":"294","author":"Makita","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"R9-1-20230423","doi-asserted-by":"crossref","first-page":"6383","DOI":"10.1128\/MCB.00254-07","article-title":"TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex","volume":"27","author":"Tian","year":"2007","journal-title":"Mol Cell Biol"},{"key":"R10-1-20230423","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1128\/MCB.01874-07","article-title":"TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway","volume":"28","author":"Lei","year":"2008","journal-title":"Mol Cell Biol"},{"key":"R11-1-20230423","doi-asserted-by":"crossref","first-page":"37159","DOI":"10.1074\/jbc.M110.152942","article-title":"The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCFbeta-TrCP E3 ligase","volume":"285","author":"Liu","year":"2010","journal-title":"J Biol Chem"},{"key":"R12-1-20230423","doi-asserted-by":"crossref","first-page":"e1076","DOI":"10.1371\/journal.pone.0001076","article-title":"Phylogenetic analysis of the Neks reveals early diversification of ciliary-cell cycle kinases","volume":"2","author":"Parker","year":"2007","journal-title":"PLoS One"},{"key":"R13-1-20230423","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1073\/pnas.97.1.217","article-title":"Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice","volume":"97","author":"Upadhya","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R14-1-20230423","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ajhg.2010.12.004","article-title":"NEK1 mutations cause short-rib polydactyly syndrome type Majewski","volume":"88","author":"Thiel","year":"2011","journal-title":"Am J Hum Genet"},{"key":"R15-1-20230423","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.devcel.2010.03.007","article-title":"The Hippo pathway regulates Wnt\/beta-catenin signaling","volume":"18","author":"Varelas","year":"2010","journal-title":"Dev Cell"},{"key":"R16-1-20230423","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1093\/hmg\/ddn208","article-title":"Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling","volume":"17","author":"Lal","year":"2008","journal-title":"Hum Mol Genet"},{"key":"R17-1-20230423","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1681\/ASN.2010070774","article-title":"Balancing the Wnts in polycystic kidney disease","volume":"21","author":"Patel","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"R18-1-20230423","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1101\/gad.2008011","article-title":"Strange as it may seem: The many links between Wnt signaling, planar cell polarity, and cilia","volume":"25","author":"Wallingford","year":"2011","journal-title":"Genes Dev"},{"key":"R19-1-20230423","doi-asserted-by":"crossref","first-page":"e6839","DOI":"10.1371\/journal.pone.0006839","article-title":"Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo","volume":"4","author":"Ocbina","year":"2009","journal-title":"PLoS One"},{"key":"R20-1-20230423","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1083\/jcb.200808137","article-title":"Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease","volume":"183","author":"Jonassen","year":"2008","journal-title":"J Cell Biol"},{"key":"R21-1-20230423","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1083\/jcb.200809144","article-title":"Inactivation of Chibby affects function of motile airway cilia","volume":"185","author":"Voronina","year":"2009","journal-title":"J Cell Biol"},{"key":"R22-1-20230423","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1128\/EC.3.5.1307-1319.2004","article-title":"Regulation of flagellar assembly by glycogen synthase kinase 3 in Chlamydomonas reinhardtii","volume":"3","author":"Wilson","year":"2004","journal-title":"Eukaryot Cell"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201105000-00001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:33:38Z","timestamp":1786131218000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201105000-00001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2011030256","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}