{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:04:28Z","timestamp":1790460268084,"version":"4.1.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1681\/asn.2012020154","type":"journal-article","created":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T01:11:06Z","timestamp":1360890666000},"page":"456-464","source":"Crossref","is-referenced-by-count":52,"title":["Proximal Tubule Proliferation Is Insufficient to Induce Rapid Cyst Formation after Cilia Disruption"],"prefix":"10.1681","volume":"24","author":[{"given":"Neeraj","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik B.","family":"Malarkey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas F.","family":"Berbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber K.","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory B.","family":"Vanden Heuvel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Mrug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley K.","family":"Yoder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20230208","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0070-2153(08)00813-2","article-title":"Ciliary dysfunction in developmental abnormalities and diseases.","volume":"85","author":"Sharma","year":"2008","journal-title":"Curr Top Dev Biol"},{"key":"R2-16-20230208","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0070-2153(08)00802-8","article-title":"Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling.","volume":"85","author":"Pedersen","year":"2008","journal-title":"Curr Top Dev Biol"},{"key":"R3-16-20230208","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1242\/dev.127.11.2347","article-title":"The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination.","volume":"127","author":"Murcia","year":"2000","journal-title":"Development"},{"key":"R4-16-20230208","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1083\/jcb.145.4.825","article-title":"Left-right asymmetry and kinesin superfamily protein KIF3A: New insights in determination of laterality and mesoderm induction by kif3A-\/- mice analysis.","volume":"145","author":"Takeda","year":"1999","journal-title":"J Cell Biol"},{"key":"R5-16-20230208","doi-asserted-by":"crossref","first-page":"a000802","DOI":"10.1101\/cshperspect.a000802","article-title":"Left-right determination: Involvement of molecular motor KIF3, cilia, and nodal flow.","volume":"1","author":"Hirokawa","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"R6-16-20230208","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.cub.2007.08.034","article-title":"Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease.","volume":"17","author":"Davenport","year":"2007","journal-title":"Curr Biol"},{"key":"R7-16-20230208","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1093\/hmg\/ddn045","article-title":"Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.","volume":"17","author":"Patel","year":"2008","journal-title":"Hum Mol Genet"},{"key":"R8-16-20230208","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00232-001-0075-4","article-title":"Bending the MDCK cell primary cilium increases intracellular calcium.","volume":"184","author":"Praetorius","year":"2001","journal-title":"J Membr Biol"},{"key":"R9-16-20230208","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ng1076","article-title":"Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells.","volume":"33","author":"Nauli","year":"2003","journal-title":"Nat Genet"},{"key":"R10-16-20230208","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/nm1675","article-title":"A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1.","volume":"13","author":"Piontek","year":"2007","journal-title":"Nat Med"},{"key":"R11-16-20230208","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1093\/hmg\/ddm299","article-title":"Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice.","volume":"16","author":"Lantinga-van Leeuwen","year":"2007","journal-title":"Hum Mol Genet"},{"key":"R12-16-20230208","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng1701","article-title":"Defective planar cell polarity in polycystic kidney disease.","volume":"38","author":"Fischer","year":"2006","journal-title":"Nat Genet"},{"key":"R13-16-20230208","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1172\/JCI117214","article-title":"Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells.","volume":"93","author":"Witzgall","year":"1994","journal-title":"J Clin Invest"},{"key":"R14-16-20230208","first-page":"831","article-title":"Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia.","volume":"140","author":"Schumer","year":"1992","journal-title":"Am J Pathol"},{"key":"R15-16-20230208","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1038\/ki.1995.249","article-title":"Rapid DNA fragmentation from hypoxia along the thick ascending limb of rat kidneys.","volume":"47","author":"Beeri","year":"1995","journal-title":"Kidney Int"},{"key":"R16-16-20230208","first-page":"F794","article-title":"Postischemic renal injury is mediated by neutrophils and leukotrienes.","volume":"256","author":"Klausner","year":"1989","journal-title":"Am J Physiol"},{"key":"R17-16-20230208","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1046\/j.1523-1755.1999.00701.x","article-title":"Cell survival or death in renal tubular epithelium after ischemia-reperfusion injury.","volume":"56","author":"Gob\u00e9","year":"1999","journal-title":"Kidney Int"},{"key":"R18-16-20230208","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1681\/ASN.2011010084","article-title":"Macrophages promote cyst growth in polycystic kidney disease.","volume":"22","author":"Karihaloo","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"R19-16-20230208","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1172\/JCI45161","article-title":"Cellular pathophysiology of ischemic acute kidney injury.","volume":"121","author":"Bonventre","year":"2011","journal-title":"J Clin Invest"},{"key":"R20-16-20230208","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/ki.1996.336","article-title":"Expression of a cut-related homeobox gene in developing and polycystic mouse kidney.","volume":"50","author":"Vanden Heuvel","year":"1996","journal-title":"Kidney Int"},{"key":"R21-16-20230208","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1093\/emboj\/17.16.4680","article-title":"The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1\/CIP1\/SDI1 in S phase.","volume":"17","author":"Coqueret","year":"1998","journal-title":"EMBO J"},{"key":"R22-16-20230208","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/dbio.2002.0636","article-title":"Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia.","volume":"245","author":"Ledford","year":"2002","journal-title":"Dev Biol"},{"key":"R24-16-20230208","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1083\/jcb.151.3.709","article-title":"Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella.","volume":"151","author":"Pazour","year":"2000","journal-title":"J Cell Biol"},{"key":"R25-16-20230208","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1242\/dev.128.9.1493","article-title":"The C. elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms.","volume":"128","author":"Haycraft","year":"2001","journal-title":"Development"},{"key":"R26-16-20230208","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1681\/ASN.2004090800","article-title":"Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease.","volume":"17","author":"Omori","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"R27-16-20230208","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nature05348","article-title":"Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine.","volume":"444","author":"Bukanov","year":"2006","journal-title":"Nature"},{"key":"R28-16-20230208","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/dbio.2002.0597","article-title":"Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: A tool for temporally regulated gene activation\/inactivation in the mouse.","volume":"244","author":"Hayashi","year":"2002","journal-title":"Dev Biol"},{"key":"R29-16-20230208","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ydbio.2011.09.001","article-title":"Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation.","volume":"360","author":"Berbari","year":"2011","journal-title":"Dev Biol"},{"key":"R30-16-20230208","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1091\/mbc.e10-03-0269","article-title":"Soluble levels of cytosolic tubulin regulate ciliary length control.","volume":"22","author":"Sharma","year":"2011","journal-title":"Mol Biol Cell"},{"key":"R31-16-20230208","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1097\/01.ASN.0000029587.47950.25","article-title":"The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia.","volume":"13","author":"Yoder","year":"2002","journal-title":"J Am Soc Nephrol"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201303000-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:22:31Z","timestamp":1786130551000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201303000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2012020154","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}