{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:39:06Z","timestamp":1790786346822,"version":"4.1.0"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1681\/asn.2012030226","type":"journal-article","created":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T00:31:59Z","timestamp":1377822719000},"page":"1627-1642","source":"Crossref","is-referenced-by-count":81,"title":["TGF-\u03b21 Promotes Lymphangiogenesis during Peritoneal Fibrosis"],"prefix":"10.1681","volume":"24","author":[{"given":"Hiroshi","family":"Kinashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Terabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Nagura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Matsukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Nishio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enyu","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Takei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20230208","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1681\/ASN.V971285","article-title":"Increased peritoneal membrane transport is associated with decreased patient and technique survival for continuous peritoneal dialysis patients.","volume":"9","author":"Churchill","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"R2-16-20230208","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1681\/ASN.2005050566","article-title":"Higher peritoneal transport status is associated with higher mortality and technique failure in the Australian and New Zealand peritoneal dialysis patient populations.","volume":"17","author":"Rumpsfeld","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"R3-16-20230208","doi-asserted-by":"crossref","first-page":"S175","DOI":"10.1177\/089686080302302s36","article-title":"Searching for the reasons for drop-out from peritoneal dialysis: A nationwide survey in Japan.","volume":"23","author":"Kawaguchi","year":"2003","journal-title":"Perit Dial Int"},{"key":"R4-16-20230208","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s10157-011-0471-8","article-title":"Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan.","volume":"15","author":"Mizuno","year":"2011","journal-title":"Clin Exp Nephrol"},{"key":"R5-16-20230208","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1681\/ASN.2006030194","article-title":"Meta-analysis: Peritoneal membrane transport, mortality, and technique failure in peritoneal dialysis.","volume":"17","author":"Brimble","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"R6-16-20230208","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1681\/ASN.V132470","article-title":"Morphologic changes in the peritoneal membrane of patients with renal disease.","volume":"13","author":"Williams","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R7-16-20230208","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1177\/089686089901900605","article-title":"Vascular and interstitial changes in the peritoneum of CAPD patients with peritoneal sclerosis.","volume":"19","author":"Mateijsen","year":"1999","journal-title":"Perit Dial Int"},{"key":"R8-16-20230208","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1093\/ndt\/gfl054","article-title":"Quantitative assessment of the peritoneal vessel density and vasculopathy in CAPD patients.","volume":"21","author":"Sherif","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"R9-16-20230208","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cell.2010.01.045","article-title":"Lymphangiogenesis: Molecular mechanisms and future promise.","volume":"140","author":"Tammela","year":"2010","journal-title":"Cell"},{"key":"R10-16-20230208","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nature04480","article-title":"Lymphangiogenesis in development and human disease.","volume":"438","author":"Alitalo","year":"2005","journal-title":"Nature"},{"key":"R11-16-20230208","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/35067005","article-title":"Tie receptors: New modulators of angiogenic and lymphangiogenic responses.","volume":"2","author":"Jones","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"R12-16-20230208","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0002-9440(10)64255-1","article-title":"Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis.","volume":"161","author":"Schoppmann","year":"2002","journal-title":"Am J Pathol"},{"key":"R13-16-20230208","doi-asserted-by":"crossref","first-page":"7205","DOI":"10.1158\/1078-0432.CCR-08-0818","article-title":"Vascular endothelial growth factor C stimulates progression of human gastric cancer via both autocrine and paracrine mechanisms.","volume":"14","author":"Kodama","year":"2008","journal-title":"Clin Cancer Res"},{"key":"R14-16-20230208","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/ijc.20859","article-title":"Quantitative analysis of lymphangiogenic markers for predicting metastasis of human gastric carcinoma to lymph nodes.","volume":"115","author":"Kitadai","year":"2005","journal-title":"Int J Cancer"},{"key":"R15-16-20230208","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1349-7006.2004.tb03167.x","article-title":"Expression of VEGF-C and VEGF-D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma.","volume":"95","author":"Onogawa","year":"2004","journal-title":"Cancer Sci"},{"key":"R16-16-20230208","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1172\/JCI200522037","article-title":"Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation.","volume":"115","author":"Baluk","year":"2005","journal-title":"J Clin Invest"},{"key":"R17-16-20230208","first-page":"2954","article-title":"TNF-\u03b1 drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice.","volume":"119","author":"Baluk","year":"2009","journal-title":"J Clin Invest"},{"key":"R18-16-20230208","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.1073\/pnas.0813368106","article-title":"Abnormal lymphangiogenesis in idiopathic pulmonary fibrosis with insights into cellular and molecular mechanisms.","volume":"106","author":"El-Chemaly","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R19-16-20230208","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0002-9440(10)65021-3","article-title":"Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing.","volume":"156","author":"Paavonen","year":"2000","journal-title":"Am J Pathol"},{"key":"R20-16-20230208","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nm1340","article-title":"Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants.","volume":"12","author":"Kerjaschki","year":"2006","journal-title":"Nat Med"},{"key":"R21-16-20230208","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/01.ASN.0000113316.52371.2E","article-title":"Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates.","volume":"15","author":"Kerjaschki","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"R22-16-20230208","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/ki.2008.661","article-title":"Lymphatic vessels develop during tubulointerstitial fibrosis.","volume":"75","author":"Sakamoto","year":"2009","journal-title":"Kidney Int"},{"key":"R23-16-20230208","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/ki.2011.464","article-title":"Transforming growth factor-\u03b2 induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction.","volume":"81","author":"Suzuki","year":"2012","journal-title":"Kidney Int"},{"key":"R24-16-20230208","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1177\/089686080402400616","article-title":"Analysis of the prevalence and causes of ultrafiltration failure during long-term peritoneal dialysis: A cross-sectional study.","volume":"24","author":"Smit","year":"2004","journal-title":"Perit Dial Int"},{"key":"R25-16-20230208","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/ndt\/gfq343","article-title":"The time course of peritoneal transport parameters in peritoneal dialysis patients who develop encapsulating peritoneal sclerosis.","volume":"26","author":"Sampimon","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"R26-16-20230208","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ki.1990.231","article-title":"Peritoneal transport in CAPD patients with permanent loss of ultrafiltration capacity.","volume":"38","author":"Heimb\u00fcrger","year":"1990","journal-title":"Kidney Int"},{"key":"R27-16-20230208","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1681\/ASN.V1341055","article-title":"Peritoneal fluid and solute transport: Influence of treatment time, peritoneal dialysis modality, and peritonitis incidence.","volume":"13","author":"Fussh\u00f6ller","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R28-16-20230208","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/089686080402400402","article-title":"The effective lymphatic absorption rate is an accurate and useful concept in the physiology of peritoneal dialysis.","volume":"24","author":"Krediet","year":"2004","journal-title":"Perit Dial Int"},{"key":"R29-16-20230208","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1177\/089686080402400403","article-title":"Effective lymphatic absorption rate is not a useful or accurate term to use in the physiology of peritoneal dialysis.","volume":"24","author":"Flessner","year":"2004","journal-title":"Perit Dial Int"},{"key":"R30-16-20230208","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1046\/j.1523-1755.2003.00169.x","article-title":"Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress peritoneal fibrosis in rats.","volume":"64","author":"Nishino","year":"2003","journal-title":"Kidney Int"},{"key":"R31-16-20230208","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1093\/ndt\/gfm323","article-title":"Inhibitory effects of matrix metalloproteinase inhibitor ONO-4817 on morphological alterations in chlorhexidine gluconate-induced peritoneal sclerosis rats.","volume":"22","author":"Ro","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"R32-16-20230208","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1093\/ndt\/gfr068","article-title":"Effects of liposome-encapsulated clodronate on chlorhexidine gluconate-induced peritoneal fibrosis in rats.","volume":"26","author":"Kushiyama","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"R33-16-20230208","doi-asserted-by":"crossref","first-page":"F721","DOI":"10.1152\/ajprenal.00368.2009","article-title":"Connective tissue growth factor (CTGF\/CCN2) is increased in peritoneal dialysis patients with high peritoneal solute transport rate.","volume":"298","author":"Mizutani","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"R34-16-20230208","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/nm1689","article-title":"Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation.","volume":"13","author":"Tammela","year":"2007","journal-title":"Nat Med"},{"key":"R35-16-20230208","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ccr.2011.12.026","article-title":"VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium.","volume":"21","author":"Karnezis","year":"2012","journal-title":"Cancer Cell"},{"key":"R36-16-20230208","doi-asserted-by":"crossref","first-page":"10181","DOI":"10.1158\/0008-5472.CAN-07-2366","article-title":"Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis.","volume":"67","author":"Iwata","year":"2007","journal-title":"Cancer Res"},{"key":"R37-16-20230208","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1177\/089686080902902S24","article-title":"Update on mechanisms of ultrafiltration failure.","volume":"29","author":"Kim","year":"2009","journal-title":"Perit Dial Int"},{"key":"R38-16-20230208","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1038\/sj.ki.5001861","article-title":"Analysis of fluid transport pathways and their determinants in peritoneal dialysis patients with ultrafiltration failure.","volume":"70","author":"Parikova","year":"2006","journal-title":"Kidney Int"},{"key":"R39-16-20230208","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/sj.ki.5000285","article-title":"Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis.","volume":"69","author":"Ni","year":"2006","journal-title":"Kidney Int"},{"key":"R40-16-20230208","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1093\/ndt\/gfr533","article-title":"High-dose steroid treatment increases free water transport in peritoneal dialysis patients.","volume":"26","author":"de Arteaga","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"R41-16-20230208","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000218008","article-title":"Intraperitoneal vascular endothelial growth factor C level is related to peritoneal dialysis ultrafiltration.","volume":"28","author":"Yang","year":"2009","journal-title":"Blood Purif"},{"key":"R42-16-20230208","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1097\/01.ASN.0000076078.50889.43","article-title":"Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: Aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels.","volume":"14","author":"Matsui","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"R43-16-20230208","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1172\/JCI26354","article-title":"The crucial role of macrophages in lymphangiogenesis.","volume":"115","author":"Kerjaschki","year":"2005","journal-title":"J Clin Invest"},{"key":"R44-16-20230208","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.2353\/ajpath.2009.090133","article-title":"Role of CD11b+ macrophages in intraperitoneal lipopolysaccharide-induced aberrant lymphangiogenesis and lymphatic function in the diaphragm.","volume":"175","author":"Kim","year":"2009","journal-title":"Am J Pathol"},{"key":"R45-16-20230208","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1172\/JCI23874","article-title":"Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages.","volume":"115","author":"Maruyama","year":"2005","journal-title":"J Clin Invest"},{"key":"R46-16-20230208","doi-asserted-by":"crossref","first-page":"8413","DOI":"10.1074\/jbc.273.14.8413","article-title":"Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C.","volume":"273","author":"Ristim\u00e4ki","year":"1998","journal-title":"J Biol Chem"},{"key":"R47-16-20230208","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1159\/000013488","article-title":"Growth factors in continuous ambulatory peritoneal dialysis effluent. Their relation with peritoneal transport of small solutes.","volume":"19","author":"Lai","year":"1999","journal-title":"Am J Nephrol"},{"key":"R48-16-20230208","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0022-2143(99)90116-6","article-title":"Growth factors VEGF and TGF-beta1 in peritoneal dialysis.","volume":"134","author":"Zweers","year":"1999","journal-title":"J Lab Clin Med"},{"key":"R49-16-20230208","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/089686089901900307","article-title":"High glucose solution and spent dialysate stimulate the synthesis of transforming growth factor-beta1 of human peritoneal mesothelial cells: Effect of cytokine costimulation.","volume":"19","author":"Kang","year":"1999","journal-title":"Perit Dial Int"},{"key":"R50-16-20230208","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1093\/ndt\/gfl271","article-title":"Myofibroblast transdifferentiation of mesothelial cells is mediated by RAGE and contributes to peritoneal fibrosis in uraemia.","volume":"21","author":"De Vriese","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"R51-16-20230208","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/ndt\/gfn524","article-title":"Regulation of CCN2\/CTGF and related cytokines in cultured peritoneal cells under conditions simulating peritoneal dialysis.","volume":"24","author":"Leung","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"R52-16-20230208","first-page":"453","article-title":"The role of the diaphragm in lymphatic absorption from the peritoneal cavity.","volume":"186","author":"Abu-Hijleh","year":"1995","journal-title":"J Anat"},{"key":"R53-16-20230208","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1172\/JCI113207","article-title":"Contribution of lymphatic absorption to loss of ultrafiltration and solute clearances in continuous ambulatory peritoneal dialysis.","volume":"80","author":"Mactier","year":"1987","journal-title":"J Clin Invest"},{"key":"R55-16-20230208","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0272-6386(00)70011-4","article-title":"Changes of cytokine profiles during peritonitis in patients on continuous ambulatory peritoneal dialysis.","volume":"35","author":"Lai","year":"2000","journal-title":"Am J Kidney Dis"},{"key":"R56-16-20230208","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1525-139X.1990.tb00029.x","article-title":"The fast peritoneal equilibration test.","volume":"3","author":"Twardowski","year":"1990","journal-title":"Semin Dial"},{"key":"R57-16-20230208","doi-asserted-by":"crossref","first-page":"720","DOI":"10.2215\/CJN.03630807","article-title":"Impact of uremia, diabetes, and peritoneal dialysis itself on the pathogenesis of peritoneal sclerosis: A quantitative study of peritoneal membrane morphology.","volume":"3","author":"Honda","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"R58-16-20230208","doi-asserted-by":"crossref","first-page":"F1084","DOI":"10.1152\/ajprenal.00565.2007","article-title":"Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model.","volume":"294","author":"Nishimura","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"R59-16-20230208","doi-asserted-by":"crossref","first-page":"H876","DOI":"10.1152\/ajpheart.01276.2005","article-title":"Functional arrangement of rat diaphragmatic initial lymphatic network.","volume":"291","author":"Grimaldi","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R60-16-20230208","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/ndt\/gfr302","article-title":"Atrial natriuretic peptide ameliorates peritoneal fibrosis in rat peritonitis model.","volume":"27","author":"Kato","year":"2012","journal-title":"Nephrol Dial Transplant"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201310000-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:23:12Z","timestamp":1786130592000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201310000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":59,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2012030226","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}