{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:08:11Z","timestamp":1790842091922,"version":"4.1.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1681\/asn.2012101006","type":"journal-article","created":{"date-parts":[[2013,5,17]],"date-time":"2013-05-17T00:54:40Z","timestamp":1368752080000},"page":"1330-1338","source":"Crossref","is-referenced-by-count":284,"title":["A Combined Epidemiologic and Metabolomic Approach Improves CKD Prediction"],"prefix":"10.1681","volume":"24","author":[{"given":"Eugene P.","family":"Rhee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clary B.","family":"Clish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahita","family":"Ghorbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sammy","family":"Elmariah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"McCabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Deik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Farrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly","family":"Domos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Palacios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Rosenfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramachandran S.","family":"Vasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose C.","family":"Florez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline S.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Gerszten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-21-20230208","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0140-6736(10)60674-5","article-title":"Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: A collaborative meta-analysis.","volume":"375","author":"Matsushita","year":"2010","journal-title":"Lancet"},{"key":"R2-21-20230208","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1681\/ASN.2009111132","article-title":"Metabolite profiling identifies markers of uremia.","volume":"21","author":"Rhee","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"R3-21-20230208","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/hr.2010.113","article-title":"Metabolomic profiling of uremic solutes in CKD patients.","volume":"33","author":"Toyohara","year":"2010","journal-title":"Hypertens Res"},{"key":"R4-21-20230208","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1681\/ASN.2009070696","article-title":"SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation.","volume":"20","author":"Toyohara","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"R5-21-20230208","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nm.2307","article-title":"Metabolite profiles and the risk of developing diabetes.","volume":"17","author":"Wang","year":"2011","journal-title":"Nat Med"},{"key":"R6-21-20230208","first-page":"E437","article-title":"Renal arginine synthesis: studies in vitro and in vivo.","volume":"259","author":"Dhanakoti","year":"1990","journal-title":"Am J Physiol"},{"key":"R7-21-20230208","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/ajcn\/79.2.185","article-title":"Renal metabolism of amino acids: Its role in interorgan amino acid exchange.","volume":"79","author":"van de Poll","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"R8-21-20230208","doi-asserted-by":"crossref","first-page":"7820","DOI":"10.1073\/pnas.88.17.7820","article-title":"Accumulation of glycerophosphocholine (GPC) by renal cells: Osmotic regulation of GPC:choline phosphodiesterase.","volume":"88","author":"Zablocki","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R9-21-20230208","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1194\/jlr.R700019-JLR200","article-title":"Phosphatidylcholine and choline homeostasis.","volume":"49","author":"Li","year":"2008","journal-title":"J Lipid Res"},{"key":"R10-21-20230208","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1146\/annurev.me.39.020188.002341","article-title":"Serum creatinine and renal function.","volume":"39","author":"Levey","year":"1988","journal-title":"Annu Rev Med"},{"key":"R11-21-20230208","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation.","volume":"130","author":"Levey","year":"1999","journal-title":"Ann Intern Med"},{"key":"R13-21-20230208","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate.","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"R14-21-20230208","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJMoa1114248","article-title":"Estimating glomerular filtration rate from serum creatinine and cystatin C.","volume":"367","author":"Inker","year":"2012","journal-title":"N Engl J Med"},{"key":"R15-21-20230208","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1172\/JCI104713","article-title":"Amino acid extraction and ammonia metabolism by the human kidney during the prolonged administration of ammonium chloride.","volume":"42","author":"Owen","year":"1963","journal-title":"J Clin Invest"},{"key":"R16-21-20230208","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1172\/JCI109771","article-title":"Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency.","volume":"65","author":"Tizianello","year":"1980","journal-title":"J Clin Invest"},{"key":"R17-21-20230208","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0272-6386(12)80312-X","article-title":"Tubulointerstitial changes as a major determinant in the progression of renal damage.","volume":"20","author":"Nath","year":"1992","journal-title":"Am J Kidney Dis"},{"key":"R18-21-20230208","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1681\/ASN.2005070757","article-title":"Chronic hypoxia and tubulointerstitial injury: A final common pathway to end-stage renal failure.","volume":"17","author":"Nangaku","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"R19-21-20230208","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1152\/physrev.1986.66.2.469","article-title":"Renal substrate metabolism.","volume":"66","author":"Wirthensohn","year":"1986","journal-title":"Physiol Rev"},{"key":"R20-21-20230208","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1515\/bchm3.1996.377.2.129","article-title":"Determination of choline dehydrogenase activity along the rat nephron.","volume":"377","author":"Miller","year":"1996","journal-title":"Biol Chem Hoppe Seyler"},{"key":"R23-21-20230208","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1007\/s00424-003-1089-9","article-title":"The SLC22 drug transporter family.","volume":"447","author":"Koepsell","year":"2004","journal-title":"Pflugers Arch"},{"key":"R24-21-20230208","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.phrs.2011.11.003","article-title":"Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3.","volume":"65","author":"Uwai","year":"2012","journal-title":"Pharmacol Res"},{"key":"R25-21-20230208","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"R26-21-20230208","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2174\/138920007780362509","article-title":"The human indoleamine 2,3-dioxygenase gene and related human genes.","volume":"8","author":"Murray","year":"2007","journal-title":"Curr Drug Metab"},{"key":"R27-21-20230208","doi-asserted-by":"crossref","first-page":"F226","DOI":"10.1152\/ajprenal.00567.2007","article-title":"Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injury.","volume":"295","author":"Mohib","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"R28-21-20230208","doi-asserted-by":"crossref","first-page":"19189","DOI":"10.1074\/jbc.M109.024042","article-title":"Kynurenic acid triggers firm arrest of leukocytes to vascular endothelium under flow conditions.","volume":"284","author":"Barth","year":"2009","journal-title":"J Biol Chem"},{"key":"R29-21-20230208","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nm.2092","article-title":"Kynurenine is an endothelium-derived relaxing factor produced during inflammation.","volume":"16","author":"Wang","year":"2010","journal-title":"Nat Med"},{"key":"R30-21-20230208","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2362.2010.02398.x","article-title":"Metabolomic analysis of human plasma from haemodialysis patients.","volume":"41","author":"Sato","year":"2011","journal-title":"Eur J Clin Invest"},{"key":"R31-21-20230208","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1053\/j.ajkd.2012.01.014","article-title":"Serum metabolite concentrations and decreased GFR in the general population.","volume":"60","author":"Goek","year":"2012","journal-title":"Am J Kidney Dis"},{"key":"R33-21-20230208","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/oxfordjournals.aje.a112813","article-title":"An investigation of coronary heart disease in families. The Framingham offspring study.","volume":"110","author":"Kannel","year":"1979","journal-title":"Am J Epidemiol"},{"key":"R34-21-20230208","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1001\/jama.291.7.844","article-title":"Predictors of new-onset kidney disease in a community-based population.","volume":"291","author":"Fox","year":"2004","journal-title":"JAMA"},{"key":"R35-21-20230208","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1172\/JCI44442","article-title":"Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans.","volume":"121","author":"Rhee","year":"2011","journal-title":"J Clin Invest"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201308000-00021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:25:14Z","timestamp":1786130714000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201308000-00021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2012101006","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718130948.793484805","asserted-by":"object"}]},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]}}}