{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:11:53Z","timestamp":1790521913802,"version":"4.1.0"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1681\/asn.2012121236","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T01:40:35Z","timestamp":1371174035000},"page":"1435-1450","source":"Crossref","is-referenced-by-count":75,"title":["Cdc42 Deficiency Causes Ciliary Abnormalities and Cystic Kidneys"],"prefix":"10.1681","volume":"24","author":[{"given":"Soo Young","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F.","family":"Chacon-Heszele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Perry","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua H.","family":"Lipschutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20230208","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/ar.1091820307","article-title":"Fine structure of mammalian renal cilia.","volume":"182","author":"Webber","year":"1975","journal-title":"Anat Rec"},{"key":"R3-15-20230208","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ydbio.2005.08.047","article-title":"Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer\u2019s vesicle are required for specification of the zebrafish left-right axis.","volume":"287","author":"Bisgrove","year":"2005","journal-title":"Dev Biol"},{"key":"R4-15-20230208","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1681\/ASN.2006040412","article-title":"Polycystin-2 immunolocalization and function in zebrafish.","volume":"17","author":"Obara","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"R5-15-20230208","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1242\/dev.02827","article-title":"Zebrafish curly up encodes a Pkd2 ortholog that restricts left-side-specific expression of southpaw.","volume":"134","author":"Schottenfeld","year":"2007","journal-title":"Development"},{"key":"R6-15-20230208","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1242\/dev.01240","article-title":"A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney.","volume":"131","author":"Sun","year":"2004","journal-title":"Development"},{"key":"R7-15-20230208","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1242\/jcs.062968","article-title":"Molecular mechanisms of protein and lipid targeting to ciliary membranes.","volume":"123","author":"Emmer","year":"2010","journal-title":"J Cell Sci"},{"key":"R8-15-20230208","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0092-8674(80)90128-2","article-title":"Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway.","volume":"21","author":"Novick","year":"1980","journal-title":"Cell"},{"key":"R9-15-20230208","doi-asserted-by":"crossref","first-page":"R212","DOI":"10.1016\/S0960-9822(02)00753-4","article-title":"Exocytosis: The many masters of the exocyst.","volume":"12","author":"Lipschutz","year":"2002","journal-title":"Curr Biol"},{"key":"R10-15-20230208","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0896-6273(00)80251-2","article-title":"The mammalian brain rsec6\/8 complex.","volume":"17","author":"Hsu","year":"1996","journal-title":"Neuron"},{"key":"R11-15-20230208","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbrc.2004.04.165","article-title":"The exocyst localizes to the primary cilium in MDCK cells.","volume":"319","author":"Rogers","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"R12-15-20230208","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1091\/mbc.e08-07-0772","article-title":"The exocyst protein Sec10 is necessary for primary ciliogenesis and cystogenesis in vitro.","volume":"20","author":"Zuo","year":"2009","journal-title":"Mol Biol Cell"},{"key":"R13-15-20230208","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1093\/emboj\/18.4.1071","article-title":"The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis.","volume":"18","author":"Guo","year":"1999","journal-title":"EMBO J"},{"key":"R14-15-20230208","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0092-8674(00)81435-X","article-title":"Sec6\/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells.","volume":"93","author":"Grindstaff","year":"1998","journal-title":"Cell"},{"key":"R15-15-20230208","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1091\/mbc.11.12.4259","article-title":"Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins.","volume":"11","author":"Lipschutz","year":"2000","journal-title":"Mol Biol Cell"},{"key":"R16-15-20230208","doi-asserted-by":"crossref","first-page":"20954","DOI":"10.1074\/jbc.M213210200","article-title":"The exocyst affects protein synthesis by acting on the translocation machinery of the endoplasmic reticulum.","volume":"278","author":"Lipschutz","year":"2003","journal-title":"J Biol Chem"},{"key":"R17-15-20230208","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/ncb728","article-title":"The exocyst is a Ral effector complex.","volume":"4","author":"Moskalenko","year":"2002","journal-title":"Nat Cell Biol"},{"key":"R18-15-20230208","doi-asserted-by":"crossref","first-page":"22469","DOI":"10.1074\/jbc.M111.238469","article-title":"The small GTPase Cdc42 is necessary for primary ciliogenesis in renal tubular epithelial cells.","volume":"286","author":"Zuo","year":"2011","journal-title":"J Biol Chem"},{"key":"R19-15-20230208","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/35019573","article-title":"The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42.","volume":"2","author":"Joberty","year":"2000","journal-title":"Nat Cell Biol"},{"key":"R20-15-20230208","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/35019582","article-title":"A mammalian PAR-3-PAR-6 complex implicated in Cdc42\/Rac1 and aPKC signalling and cell polarity.","volume":"2","author":"Lin","year":"2000","journal-title":"Nat Cell Biol"},{"key":"R21-15-20230208","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.cub.2004.08.025","article-title":"Polarity proteins control ciliogenesis via kinesin motor interactions.","volume":"14","author":"Fan","year":"2004","journal-title":"Curr Biol"},{"key":"R22-15-20230208","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1083\/jcb.200709111","article-title":"Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells.","volume":"179","author":"Sfakianos","year":"2007","journal-title":"J Cell Biol"},{"key":"R23-15-20230208","doi-asserted-by":"crossref","first-page":"46745","DOI":"10.1074\/jbc.M107464200","article-title":"Cdc42 interacts with the exocyst and regulates polarized secretion.","volume":"276","author":"Zhang","year":"2001","journal-title":"J Biol Chem"},{"key":"R24-15-20230208","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1083\/jcb.142.1.85","article-title":"Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity.","volume":"142","author":"Jou","year":"1998","journal-title":"J Cell Biol"},{"key":"R25-15-20230208","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1083\/jcb.142.1.101","article-title":"Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases.","volume":"142","author":"Jou","year":"1998","journal-title":"J Cell Biol"},{"key":"R26-15-20230208","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1046\/j.1523-1755.2003.00902.x","article-title":"The Rho family of small GTPases is involved in epithelial cystogenesis and tubulogenesis.","volume":"63","author":"Rogers","year":"2003","journal-title":"Kidney Int"},{"key":"R27-15-20230208","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1242\/jcs.014902","article-title":"Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC.","volume":"120","author":"Atwood","year":"2007","journal-title":"J Cell Sci"},{"key":"R28-15-20230208","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1046\/j.1365-2443.2001.00453.x","article-title":"PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.","volume":"6","author":"Yamanaka","year":"2001","journal-title":"Genes Cells"},{"key":"R29-15-20230208","doi-asserted-by":"crossref","first-page":"e1001361","DOI":"10.1371\/journal.pgen.1001361","article-title":"The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes.","volume":"7","author":"Fogelgren","year":"2011","journal-title":"PLoS Genet"},{"key":"R30-15-20230208","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.neuron.2011.03.002","article-title":"Cilia in the CNS: The quiet organelle claims center stage.","volume":"69","author":"Louvi","year":"2011","journal-title":"Neuron"},{"key":"R31-15-20230208","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ydbio.2007.11.025","article-title":"Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants.","volume":"314","author":"Sullivan-Brown","year":"2008","journal-title":"Dev Biol"},{"key":"R32-15-20230208","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1242\/dev.01772","article-title":"Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer\u2019s vesicle is required for normal organogenesis.","volume":"132","author":"Kramer-Zucker","year":"2005","journal-title":"Development"},{"key":"R33-15-20230208","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1242\/dev.020735","article-title":"Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning.","volume":"136","author":"Serluca","year":"2009","journal-title":"Development"},{"key":"R34-15-20230208","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1101\/gad.361406","article-title":"Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.","volume":"20","author":"Wu","year":"2006","journal-title":"Genes Dev"},{"key":"R35-15-20230208","doi-asserted-by":"crossref","first-page":"5286","DOI":"10.1073\/pnas.0836980100","article-title":"Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease.","volume":"100","author":"Lin","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R36-15-20230208","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1159\/000070812","article-title":"Following the expression of a kidney-specific gene from early development to adulthood.","volume":"94","author":"Igarashi","year":"2003","journal-title":"Nephron, Exp Nephrol"},{"key":"R37-15-20230208","first-page":"F599","article-title":"Ksp-cadherin gene promoter. II. Kidney-specific activity in transgenic mice.","volume":"277","author":"Igarashi","year":"1999","journal-title":"Am J Physiol"},{"key":"R38-15-20230208","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/ng.400","article-title":"Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis.","volume":"41","author":"Karner","year":"2009","journal-title":"Nat Genet"},{"key":"R39-15-20230208","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.cell.2006.11.051","article-title":"PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.","volume":"128","author":"Martin-Belmonte","year":"2007","journal-title":"Cell"},{"key":"R40-15-20230208","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/ng2072","article-title":"Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis.","volume":"39","author":"Attanasio","year":"2007","journal-title":"Nat Genet"},{"key":"R41-15-20230208","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1681\/ASN.2004090800","article-title":"Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease.","volume":"17","author":"Omori","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"R42-15-20230208","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0091-679X(08)94014-0","article-title":"Polycystic kidney disease, cilia, and planar polarity.","volume":"94","author":"Menezes","year":"2009","journal-title":"Methods Cell Biol"},{"key":"R43-15-20230208","doi-asserted-by":"crossref","first-page":"5329","DOI":"10.1242\/dev.02153","article-title":"Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus.","volume":"132","author":"Banizs","year":"2005","journal-title":"Development"},{"key":"R44-15-20230208","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1091\/mbc.e05-01-0061","article-title":"Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells.","volume":"16","author":"Czuchra","year":"2005","journal-title":"Mol Biol Cell"},{"key":"R45-15-20230208","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1681\/ASN.2011121206","article-title":"Podocyte-specific loss of Cdc42 leads to congenital nephropathy.","volume":"23","author":"Scott","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"R46-15-20230208","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1073\/pnas.96.9.5043","article-title":"Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II.","volume":"96","author":"Marszalek","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R47-15-20230208","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1083\/jcb.145.4.825","article-title":"Left-right asymmetry and kinesin superfamily protein KIF3A: New insights in determination of laterality and mesoderm induction by kif3A-\/- mice analysis.","volume":"145","author":"Takeda","year":"1999","journal-title":"J Cell Biol"},{"key":"R48-15-20230208","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00467-010-1585-z","article-title":"Nephronophthisis.","volume":"26","author":"Wolf","year":"2011","journal-title":"Pediatr Nephrol"},{"key":"R49-15-20230208","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations.","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat Methods"},{"key":"R50-15-20230208","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1101\/gr.212802","article-title":"Accounting for human polymorphisms predicted to affect protein function.","volume":"12","author":"Ng","year":"2002","journal-title":"Genome Res"},{"key":"R52-15-20230208","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0272-6386(12)80507-5","article-title":"Polycystic kidney disease: neoplasia in disguise.","volume":"15","author":"Grantham","year":"1990","journal-title":"Am J Kidney Dis"},{"key":"R53-15-20230208","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1681\/ASN.2007070730","article-title":"The subcellular localization of TRPP2 modulates its function.","volume":"19","author":"Fu","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"R54-15-20230208","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/ncb1977","article-title":"Intraflagellar transport is required for polarized recycling of the TCR\/CD3 complex to the immune synapse.","volume":"11","author":"Finetti","year":"2009","journal-title":"Nat Cell Biol"},{"key":"R55-15-20230208","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1083\/jcb.201002097","article-title":"Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation.","volume":"189","author":"Qin","year":"2010","journal-title":"J Cell Biol"},{"key":"R56-15-20230208","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/nature08895","article-title":"Functional genomic screen for modulators of ciliogenesis and cilium length.","volume":"464","author":"Kim","year":"2010","journal-title":"Nature"},{"key":"R57-15-20230208","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1083\/jcb.201002047","article-title":"The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis.","volume":"189","author":"Rodriguez-Fraticelli","year":"2010","journal-title":"J Cell Biol"},{"key":"R58-15-20230208","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/002215540205000411","article-title":"Improvement of non-radioactive in situ hybridization in human airway tissues: Use of PCR-generated templates for synthesis of probes and an antibody sandwich technique for detection of hybridization.","volume":"50","author":"Divjak","year":"2002","journal-title":"J Histochem Cytochem"},{"key":"R59-15-20230208","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2164-11-13","article-title":"Sex-dimorphic gene expression and ineffective dosage compensation of Z-linked genes in gastrulating chicken embryos.","volume":"11","author":"Zhang","year":"2010","journal-title":"BMC Genomics"},{"key":"R60-15-20230208","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nprot.2007.514","article-title":"High-resolution in situ hybridization to whole-mount zebrafish embryos.","volume":"3","author":"Thisse","year":"2008","journal-title":"Nat Protoc"},{"key":"R61-15-20230208","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0091-679X(10)97022-2","article-title":"Imaging cilia in zebrafish.","volume":"97","author":"Jaffe","year":"2010","journal-title":"Methods Cell Biol"},{"key":"R62-15-20230208","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1097\/01.ASN.0000016444.90348.50","article-title":"Epithelial-specific Cre\/lox recombination in the developing kidney and genitourinary tract.","volume":"13","author":"Shao","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R63-15-20230208","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1477-5956-6-25","article-title":"A simple and reliable protocol for mouse serum proteome profiling studies by use of two-dimensional electrophoresis and MALDI TOF\/TOF mass spectrometry.","volume":"6","author":"Ritorto","year":"2008","journal-title":"Proteome Sci"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201309000-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:23:01Z","timestamp":1786130581000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201309000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":61,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2012121236","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718227614.793489243","asserted-by":"object"}]},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}