{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:45:09Z","timestamp":1791888309369,"version":"4.3.4"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1681\/asn.2013060653","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T23:31:04Z","timestamp":1392334264000},"page":"1163-1169","source":"Crossref","is-referenced-by-count":90,"title":["Inflammasome Activation by Cystine Crystals"],"prefix":"10.1681","volume":"25","author":[{"given":"Giusi","family":"Prencipe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Caiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Cherqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Whisenant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Petrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Emma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"De Benedetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20230208","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMra020552","article-title":"Cystinosis.","volume":"347","author":"Gahl","year":"2002","journal-title":"N Engl J Med"},{"key":"R2-9-20230208","doi-asserted-by":"crossref","first-page":"F905","DOI":"10.1152\/ajprenal.00318.2010","article-title":"The pathogenesis of cystinosis: Mechanisms beyond cystine accumulation.","volume":"299","author":"Wilmer","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"R3-9-20230208","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.smim.2009.05.002","article-title":"The NLRP3 inflammasome: A sensor of immune danger signals.","volume":"21","author":"Cassel","year":"2009","journal-title":"Semin Immunol"},{"key":"R4-9-20230208","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease.","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature"},{"key":"R5-9-20230208","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes.","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"R6-9-20230208","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1600-065X.2011.01043.x","article-title":"Sensing damage by the NLRP3 inflammasome.","volume":"243","author":"Leemans","year":"2011","journal-title":"Immunol Rev"},{"key":"R7-9-20230208","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ni.1631","article-title":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.","volume":"9","author":"Hornung","year":"2008","journal-title":"Nat Immunol"},{"key":"R8-9-20230208","doi-asserted-by":"crossref","first-page":"14867","DOI":"10.1073\/pnas.1111101108","article-title":"NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy.","volume":"108","author":"Jin","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R9-9-20230208","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome.","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"R10-9-20230208","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.4049\/jimmunol.1001284","article-title":"Basic calcium phosphate crystals induce monocyte\/macrophage IL-1\u03b2 secretion through the NLRP3 inflammasome in vitro.","volume":"186","author":"Paz\u00e1r","year":"2011","journal-title":"J Immunol"},{"key":"R11-9-20230208","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"R12-9-20230208","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.","volume":"320","author":"Dostert","year":"2008","journal-title":"Science"},{"key":"R13-9-20230208","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ni.2237","article-title":"Regulation of inflammasome signaling.","volume":"13","author":"Rathinam","year":"2012","journal-title":"Nat Immunol"},{"key":"R14-9-20230208","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nri2725","article-title":"NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"R15-9-20230208","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/BOR.0b013e32834dd2d5","article-title":"Familial Mediterranean fever and related periodic fever syndromes\/autoinflammatory diseases.","volume":"24","author":"Savic","year":"2012","journal-title":"Curr Opin Rheumatol"},{"key":"R16-9-20230208","doi-asserted-by":"crossref","first-page":"7622","DOI":"10.1128\/MCB.22.21.7622-7632.2002","article-title":"Intralysosomal cystine accumulation in mice lacking cystinosin, the protein defective in cystinosis.","volume":"22","author":"Cherqui","year":"2002","journal-title":"Mol Cell Biol"},{"key":"R17-9-20230208","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1172\/JCI63679","article-title":"Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1\u03b2 secretion.","volume":"123","author":"Mulay","year":"2013","journal-title":"J Clin Invest"},{"key":"R18-9-20230208","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1681\/ASN.2004121075","article-title":"IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment.","volume":"16","author":"Kitching","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"R19-9-20230208","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.clim.2008.03.501","article-title":"Deletion of IL-18 receptor ameliorates renal injury in bovine serum albumin-induced glomerulonephritis.","volume":"128","author":"Sugiyama","year":"2008","journal-title":"Clin Immunol"},{"key":"R20-9-20230208","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1681\/ASN.2008020170","article-title":"IL-18 contributes to renal damage after ischemia-reperfusion.","volume":"19","author":"Wu","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"R21-9-20230208","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile inflammation: Sensing and reacting to damage.","volume":"10","author":"Chen","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"R22-9-20230208","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1046\/j.1523-1755.2002.00103.x","article-title":"BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells.","volume":"61","author":"Gould","year":"2002","journal-title":"Kidney Int"},{"key":"R23-9-20230208","first-page":"137","article-title":"Infantile cystinosis: A reappraisal of early and late symptoms.","volume":"10","author":"Broyer","year":"1981","journal-title":"Adv Nephrol Necker Hosp"},{"key":"R24-9-20230208","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1056\/NEJM199304223281604","article-title":"Improved renal function in children with cystinosis treated with cysteamine.","volume":"328","author":"Markello","year":"1993","journal-title":"N Engl J Med"},{"key":"R25-9-20230208","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1126\/science.1191968","article-title":"Crystal growth inhibitors for the prevention of L-cystine kidney stones through molecular design.","volume":"330","author":"Rimer","year":"2010","journal-title":"Science"},{"key":"R26-9-20230208","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/clinchem\/43.4.687","article-title":"Novel reductant for determination of total plasma homocysteine.","volume":"43","author":"Gilfix","year":"1997","journal-title":"Clin Chem"},{"key":"R27-9-20230208","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data.","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201406000-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:23:50Z","timestamp":1786130630000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201406000-00009"}},"subtitle":["Implications for the Pathogenesis of Cystinosis"],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2013060653","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}