{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:48:51Z","timestamp":1790434131412,"version":"4.1.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1681\/asn.2013090988","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T21:46:06Z","timestamp":1389303966000},"page":"501-510","source":"Crossref","is-referenced-by-count":52,"title":["Lithium Causes G2 Arrest of Renal Principal Cells"],"prefix":"10.1681","volume":"25","author":[{"given":"Theun","family":"de Groot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Alsady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Jaklofsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Otte-H\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Baumgarten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel H.","family":"Giles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.T.","family":"Deen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20230306","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1681\/ASN.V103666","article-title":"Lithium intoxication.","volume":"10","author":"Timmer","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"R2-12-20230306","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1523-1755.2005.00081.x","article-title":"Lithium-induced reduction in urinary concentrating ability and urinary aquaporin 2 (AQP2) excretion in healthy volunteers.","volume":"67","author":"Walker","year":"2005","journal-title":"Kidney Int"},{"key":"R3-12-20230306","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2165\/00002018-199921060-00002","article-title":"Drug-induced diabetes insipidus: Incidence, prevention and management.","volume":"21","author":"Bendz","year":"1999","journal-title":"Drug Saf"},{"key":"R4-12-20230306","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/S0140-6736(13)60857-0","article-title":"Treatment of bipolar disorder.","volume":"381","author":"Geddes","year":"2013","journal-title":"Lancet"},{"key":"R5-12-20230306","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00424-008-0498-1","article-title":"Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.","volume":"456","author":"Boone","year":"2008","journal-title":"Pflugers Arch"},{"key":"R6-12-20230306","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/ki.2009.91","article-title":"Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus.","volume":"76","author":"Kortenoeven","year":"2009","journal-title":"Kidney Int"},{"key":"R7-12-20230306","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1681\/ASN.2010070734","article-title":"alphaENaC-mediated lithium absorption promotes nephrogenic diabetes insipidus.","volume":"22","author":"Christensen","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"R8-12-20230306","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1073\/pnas.74.7.3099","article-title":"Lithium efflux through the Na\/K pump in human erythrocytes.","volume":"74","author":"Dunham","year":"1977","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R9-12-20230306","doi-asserted-by":"crossref","first-page":"F455","DOI":"10.1152\/ajprenal.00144.2011","article-title":"Tissue injury after lithium treatment in human and rat postnatal kidney involves glycogen synthase kinase-3\u03b2-positive epithelium.","volume":"302","author":"Kjaersgaard","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"R10-12-20230306","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1681\/ASN.2009060672","article-title":"GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity.","volume":"21","author":"Rao","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"R11-12-20230306","doi-asserted-by":"crossref","first-page":"F642","DOI":"10.1152\/ajprenal.00287.2004","article-title":"Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria.","volume":"288","author":"Rao","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"R12-12-20230306","doi-asserted-by":"crossref","first-page":"C131","DOI":"10.1152\/ajpcell.00197.2011","article-title":"Lithium reduces aquaporin-2 transcription independent of prostaglandins.","volume":"302","author":"Kortenoeven","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"R13-12-20230306","doi-asserted-by":"crossref","first-page":"68","DOI":"10.5049\/EBP.2007.5.2.68","article-title":"Dysregulation of renal cyclooxygenase-2 in rats with lithium-induced nephrogenic diabetes insipidus.","volume":"5","author":"Kwon","year":"2007","journal-title":"Electrolyte Blood Press"},{"key":"R14-12-20230306","doi-asserted-by":"crossref","first-page":"C952","DOI":"10.1152\/ajpcell.00266.2003","article-title":"Changes in cellular composition of kidney collecting duct cells in rats with lithium-induced NDI.","volume":"286","author":"Christensen","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"R15-12-20230306","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1530\/eje.1.02038","article-title":"Lithium stimulates proliferation in cultured thyrocytes by activating Wnt\/beta-catenin signalling.","volume":"153","author":"Rao","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"R16-12-20230306","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1073\/pnas.0800001105","article-title":"Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: Mechanisms for aquaporin 2 down-regulation and cellular proliferation.","volume":"105","author":"Nielsen","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R17-12-20230306","doi-asserted-by":"crossref","first-page":"F39","DOI":"10.1152\/ajprenal.00383.2005","article-title":"Lithium treatment induces a marked proliferation of primarily principal cells in rat kidney inner medullary collecting duct.","volume":"291","author":"Christensen","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"R18-12-20230306","doi-asserted-by":"crossref","first-page":"F1276","DOI":"10.1152\/ajprenal.00305.2004","article-title":"Altered expression of selected genes in kidney of rats with lithium-induced NDI.","volume":"288","author":"Rojek","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"R19-12-20230306","doi-asserted-by":"crossref","first-page":"10379","DOI":"10.1074\/jbc.M111880200","article-title":"Long term regulation of aquaporin-2 expression in vasopressin-responsive renal collecting duct principal cells.","volume":"277","author":"Hasler","year":"2002","journal-title":"J Biol Chem"},{"key":"R20-12-20230306","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/ng.662","article-title":"Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy.","volume":"42","author":"Otto","year":"2010","journal-title":"Nat Genet"},{"key":"R21-12-20230306","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1101\/gad.12.22.3499","article-title":"Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.","volume":"12","author":"Diehl","year":"1998","journal-title":"Genes Dev"},{"key":"R22-12-20230306","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.carrev.2006.02.002","article-title":"A concise review of DNA damage checkpoints and repair in mammalian cells.","volume":"7","author":"Houtgraaf","year":"2006","journal-title":"Cardiovasc Revasc Med"},{"key":"R23-12-20230306","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1038\/onc.2011.135","article-title":"Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM\/p53\/p21 pathway is functional.","volume":"30","author":"Lossaint","year":"2011","journal-title":"Oncogene"},{"key":"R24-12-20230306","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nm.2144","article-title":"Epithelial cell cycle arrest in G2\/M mediates kidney fibrosis after injury.","volume":"16","author":"Yang","year":"2010","journal-title":"Nat Med"},{"key":"R25-12-20230306","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/ncb0901-831","article-title":"Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly.","volume":"3","author":"O\u2019Brien","year":"2001","journal-title":"Nat Cell Biol"},{"key":"R26-12-20230306","first-page":"526","article-title":"Effects of long-term lithium administration on renal structure and function in rats. A distinctive tubular lesion.","volume":"50","author":"Kling","year":"1984","journal-title":"Lab Invest"},{"key":"R27-12-20230306","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.4161\/cc.3.11.1225","article-title":"Chk1 versus Cdc25: Chking one\u2019s levels of cellular proliferation.","volume":"3","author":"Lam","year":"2004","journal-title":"Cell Cycle"},{"key":"R28-12-20230306","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1158\/1078-0432.CCR-06-1424","article-title":"CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo.","volume":"13","author":"Tse","year":"2007","journal-title":"Clin Cancer Res"},{"key":"R29-12-20230306","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1002\/jcb.21693","article-title":"Involvement of the role of Chk1 in lithium-induced G2\/M phase cell cycle arrest in hepatocellular carcinoma cells.","volume":"104","author":"Wang","year":"2008","journal-title":"J Cell Biochem"},{"key":"R30-12-20230306","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.canlet.2007.06.018","article-title":"23,24-Dihydrocucurbitacin B induces G2\/M cell-cycle arrest and mitochondria-dependent apoptosis in human breast cancer cells (Bcap37).","volume":"256","author":"Yang","year":"2007","journal-title":"Cancer Lett"},{"key":"R31-12-20230306","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.toxlet.2013.02.012","article-title":"Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages.","volume":"219","author":"Solhaug","year":"2013","journal-title":"Toxicol Lett"},{"key":"R32-12-20230306","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1248\/bpb.34.831","article-title":"Natural plant extract tubeimoside I promotes apoptosis-mediated cell death in cultured human hepatoma (HepG2) cells.","volume":"34","author":"Wang","year":"2011","journal-title":"Biol Pharm Bull"},{"key":"R33-12-20230306","doi-asserted-by":"crossref","first-page":"F300","DOI":"10.1152\/ajprenal.00182.2012","article-title":"Chronic interstitial fibrosis in the rat kidney induced by long-term (6-mo) exposure to lithium.","volume":"304","author":"Walker","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"R34-12-20230306","first-page":"298","article-title":"Early changes in renal distal convoluted tubules and collecting ducts of lithium-treated rats: Light microscopy, enzyme histochemistry, and 3H-thymidine autoradiography.","volume":"46","author":"Jacobsen","year":"1982","journal-title":"Lab Invest"},{"key":"R35-12-20230306","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1681\/ASN.2012080866","article-title":"Aqp2-expressing cells give rise to renal intercalated cells.","volume":"24","author":"Wu","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"R36-12-20230306","doi-asserted-by":"crossref","first-page":"F37","DOI":"10.1152\/ajprenal.00046.2006","article-title":"Lithium treatment and remodeling of the collecting duct.","volume":"291","author":"Ecelbarger","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"R37-12-20230306","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/BF00215513","article-title":"A morphometric and ultrastructural study of lithium-induced changes in the medullary collecting ducts of the rat kidney.","volume":"249","author":"Ottosen","year":"1987","journal-title":"Cell Tissue Res"},{"key":"R38-12-20230306","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/ki.1976.40","article-title":"Lithium-induced impairment of urine acidification.","volume":"9","author":"Roscoe","year":"1976","journal-title":"Kidney Int"},{"key":"R39-12-20230306","first-page":"386","article-title":"Incomplete syndrome of renal tubular acidosis induced by lithium carbonate.","volume":"86","author":"Perez","year":"1975","journal-title":"J Lab Clin Med"},{"key":"R40-12-20230306","doi-asserted-by":"crossref","first-page":"F1244","DOI":"10.1152\/ajprenal.00176.2003","article-title":"Altered expression of renal acid-base transporters in rats with lithium-induced NDI.","volume":"285","author":"Kim","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"R41-12-20230306","doi-asserted-by":"crossref","first-page":"e25240","DOI":"10.1371\/journal.pone.0025240","article-title":"Proliferation of acid-secretory cells in the kidney during adaptive remodelling of the collecting duct.","volume":"6","author":"Welsh-Bacic","year":"2011","journal-title":"PLoS ONE"},{"key":"R42-12-20230306","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.humpath.2009.12.015","article-title":"High levels of p53 expression correlate with DNA aneuploidy in (pre)malignancies of the vulva.","volume":"41","author":"van der Avoort","year":"2010","journal-title":"Hum Pathol"},{"key":"R43-12-20230306","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1093\/emboj\/18.9.2394","article-title":"An impaired routing of wild-type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus.","volume":"18","author":"Kamsteeg","year":"1999","journal-title":"EMBO J"},{"key":"R44-12-20230306","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1681\/ASN.2008060648","article-title":"LIP5 interacts with aquaporin 2 and facilitates its lysosomal degradation.","volume":"20","author":"van Balkom","year":"2009","journal-title":"J Am Soc Nephrol"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201403000-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:23:39Z","timestamp":1786130619000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201403000-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2013090988","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}