{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:31:09Z","timestamp":1791959469144,"version":"4.3.4"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1681\/asn.2013121283","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T22:35:36Z","timestamp":1408660536000},"page":"876-887","source":"Crossref","is-referenced-by-count":319,"title":["The Cardiovascular Effect of the Uremic Solute Indole-3 Acetic Acid"],"prefix":"10.1681","volume":"26","author":[{"given":"Laetitia","family":"Dou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Sall\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Cerini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Poitevin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Gondouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemie","family":"Jourde-Chiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Fallague","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Brunet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Calaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Dussol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Mallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Dignat-George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Burtey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-16-20230208","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/MNH.0b013e32830f45b6","article-title":"New insights into uremic toxicity.","volume":"17","author":"Raff","year":"2008","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"R3-16-20230208","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1681\/ASN.2011121175","article-title":"Normal and pathologic concentrations of uremic toxins.","volume":"23","author":"Duranton","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"R4-16-20230208","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1525-139X.2011.00925.x","article-title":"Vascular incompetence in dialysis patients\u2014protein-bound uremic toxins and endothelial dysfunction.","volume":"24","author":"Jourde-Chiche","year":"2011","journal-title":"Semin Dial"},{"key":"R5-16-20230208","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1111\/j.1538-7836.2007.02540.x","article-title":"The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells.","volume":"5","author":"Dou","year":"2007","journal-title":"J Thromb Haemost"},{"key":"R6-16-20230208","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1525-139X.2009.00593.x","article-title":"Platelet\/leukocyte activation, inflammation, and uremia.","volume":"22","author":"Glorieux","year":"2009","journal-title":"Semin Dial"},{"key":"R7-16-20230208","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1525-139X.2009.00576.x","article-title":"Protein-bound toxins\u2014update 2009.","volume":"22","author":"Jourde-Chiche","year":"2009","journal-title":"Semin Dial"},{"key":"R8-16-20230208","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1046\/j.1523-1755.2003.00924.x","article-title":"Review on uremic toxins: Classification, concentration, and interindividual variability.","volume":"63","author":"Vanholder","year":"2003","journal-title":"Kidney Int"},{"key":"R9-16-20230208","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/ki.2013.133","article-title":"Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway.","volume":"84","author":"Gondouin","year":"2013","journal-title":"Kidney Int"},{"key":"R10-16-20230208","doi-asserted-by":"crossref","first-page":"11508","DOI":"10.1021\/bi980087p","article-title":"Activation of the Ah receptor by tryptophan and tryptophan metabolites.","volume":"37","author":"Heath-Pagliuso","year":"1998","journal-title":"Biochemistry"},{"key":"R11-16-20230208","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.bcp.2008.09.013","article-title":"Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways.","volume":"77","author":"Haarmann-Stemmann","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"R12-16-20230208","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.taap.2010.02.007","article-title":"2,3,7,8-tetrachlorodibenzo-p-dioxin increases reactive oxygen species production in human endothelial cells via induction of cytochrome P4501A1.","volume":"245","author":"Kopf","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"R13-16-20230208","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1161\/ATVBAHA.110.220202","article-title":"Activation of aryl hydrocarbon receptor induces vascular inflammation and promotes atherosclerosis in apolipoprotein E-\/- mice.","volume":"31","author":"Wu","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R14-16-20230208","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/03602530600632063","article-title":"The role of aryl hydrocarbon receptor in the pathogenesis of cardiovascular diseases.","volume":"38","author":"Korashy","year":"2006","journal-title":"Drug Metab Rev"},{"key":"R15-16-20230208","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.pharmthera.2008.01.002","article-title":"Cyclooxygenase and prostaglandin synthases in atherosclerosis: Recent insights and future perspectives.","volume":"118","author":"Cipollone","year":"2008","journal-title":"Pharmacol Ther"},{"key":"R16-16-20230208","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.2215\/CJN.03980609","article-title":"Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients.","volume":"4","author":"Barreto","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"R17-16-20230208","doi-asserted-by":"crossref","first-page":"e67168","DOI":"10.1371\/journal.pone.0067168","article-title":"Does p-cresylglucuronide have the same impact on mortality as other protein-bound uremic toxins?","volume":"8","author":"Liabeuf","year":"2013","journal-title":"PLoS ONE"},{"key":"R18-16-20230208","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1093\/ndt\/gfp592","article-title":"Free p-cresylsulphate is a predictor of mortality in patients at different stages of chronic kidney disease.","volume":"25","author":"Liabeuf","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"R19-16-20230208","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1093\/ndt\/gfr453","article-title":"Serum free p-cresyl sulfate levels predict cardiovascular and all-cause mortality in elderly hemodialysis patients\u2014a prospective cohort study.","volume":"27","author":"Wu","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"R20-16-20230208","doi-asserted-by":"crossref","first-page":"e76838","DOI":"10.1371\/journal.pone.0076838","article-title":"Does the adequacy parameter Kt\/V(urea) reflect uremic toxin concentrations in hemodialysis patients?","volume":"8","author":"Eloot","year":"2013","journal-title":"PLoS ONE"},{"key":"R21-16-20230208","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1002\/jps.22592","article-title":"Update on the pharmacokinetics and redox properties of protein-bound uremic toxins.","volume":"100","author":"Watanabe","year":"2011","journal-title":"J Pharm Sci"},{"key":"R22-16-20230208","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1093\/ndt\/gfm065","article-title":"Effect of the super-flux cellulose triacetate dialyser membrane on the removal of non-protein-bound and protein-bound uraemic solutes.","volume":"22","author":"De Smet","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"R23-16-20230208","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1093\/ndt\/gfq053","article-title":"Serological cardiovascular and mortality risk predictors in dialysis patients receiving sevelamer: a prospective study.","volume":"25","author":"Brandenburg","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"R24-16-20230208","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.2215\/CJN.09981110","article-title":"Estimated glomerular filtration rate is a poor predictor of concentration for a broad range of uremic toxins.","volume":"6","author":"Eloot","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"R25-16-20230208","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0009-2797(02)00067-4","article-title":"Induction of cellular oxidative stress by aryl hydrocarbon receptor activation.","volume":"141","author":"Dalton","year":"2002","journal-title":"Chem Biol Interact"},{"key":"R26-16-20230208","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1080\/01635580701485585","article-title":"Cyclooxygenase-2 promoter activation by the aromatic hydrocarbon receptor in breast cancer mcf-7 cells: Repressive effects of conjugated linoleic acid.","volume":"59","author":"Degner","year":"2007","journal-title":"Nutr Cancer"},{"key":"R27-16-20230208","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1476-5381.2011.01276.x","article-title":"Endothelium-mediated control of vascular tone: COX-1 and COX-2 products.","volume":"164","author":"F\u00e9l\u00e9tou","year":"2011","journal-title":"Br J Pharmacol"},{"key":"R28-16-20230208","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1161\/hc3401.093152","article-title":"Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability.","volume":"104","author":"Cipollone","year":"2001","journal-title":"Circulation"},{"key":"R29-16-20230208","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/eurheartj\/ehi016","article-title":"Monocyte cyclooxygenase-2 overactivity: A new marker of subclinical atherosclerosis in asymptomatic subjects with cardiovascular risk factors?","volume":"26","author":"Beloqui","year":"2005","journal-title":"Eur Heart J"},{"key":"R30-16-20230208","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1161\/01.CIR.0000014927.74465.7F","article-title":"Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice.","volume":"105","author":"Burleigh","year":"2002","journal-title":"Circulation"},{"key":"R31-16-20230208","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000156715","article-title":"Effect of exercise on cardiac tissue oxidative and inflammatory mediators in chronic kidney disease.","volume":"29","author":"Bai","year":"2009","journal-title":"Am J Nephrol"},{"key":"R32-16-20230208","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000316479","article-title":"ApoA-1 mimetic peptide reverses uremia-induced upregulation of pro-atherogenic pathways in the aorta.","volume":"32","author":"Vaziri","year":"2010","journal-title":"Am J Nephrol"},{"key":"R33-16-20230208","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00109-009-0543-3","article-title":"Increased type IIA secretory phospholipase A(2) expression contributes to oxidative stress in end-stage renal disease.","volume":"88","author":"van der Giet","year":"2010","journal-title":"J Mol Med (Berl"},{"key":"R34-16-20230208","doi-asserted-by":"crossref","first-page":"e43374","DOI":"10.1371\/journal.pone.0043374","article-title":"NF\u03baB in the development of endothelial activation and damage in uremia: An in vitro approach.","volume":"7","author":"Caballo","year":"2012","journal-title":"PLoS ONE"},{"key":"R35-16-20230208","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1478-811X-11-8","article-title":"Up-regulation of COX-2\/PGE2 by endothelin-1 via MAPK-dependent NF-\u03baB pathway in mouse brain microvascular endothelial cells.","volume":"11","author":"Lin","year":"2013","journal-title":"Cell Commun Signal"},{"key":"R36-16-20230208","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1742-2094-9-152","article-title":"c-Src-dependent EGF receptor transactivation contributes to ET-1-induced COX-2 expression in brain microvascular endothelial cells.","volume":"9","author":"Hsieh","year":"2012","journal-title":"J Neuroinflammation"},{"key":"R37-16-20230208","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.bcp.2009.08.031","article-title":"TCDD-induced cyclooxygenase-2 expression is mediated by the nongenomic pathway in mouse MMDD1 macula densa cells and kidneys.","volume":"79","author":"Dong","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"R38-16-20230208","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1515\/bc.2010.126","article-title":"Non-genomic action of TCDD to induce inflammatory responses in HepG2 human hepatoma cells and in liver of C57BL\/6J mice.","volume":"391","author":"Li","year":"2010","journal-title":"Biol Chem"},{"key":"R39-16-20230208","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/carcin\/21.5.973","article-title":"The COX-2 inhibitor nimesulide suppresses superoxide and 8-hydroxy-deoxyguanosine formation, and stimulates apoptosis in mucosa during early colonic inflammation in rats.","volume":"21","author":"Tardieu","year":"2000","journal-title":"Carcinogenesis"},{"key":"R40-16-20230208","doi-asserted-by":"crossref","first-page":"S332","DOI":"10.1097\/01.fjc.0000166267.17174.0e","article-title":"Endothelin-1 induces cyclooxygenase-2 expression and generation of reactive oxygen species in endothelial cells.","volume":"44","author":"Sugiyama","year":"2004","journal-title":"J Cardiovasc Pharmacol"},{"key":"R41-16-20230208","doi-asserted-by":"crossref","first-page":"H2023","DOI":"10.1152\/ajpheart.01283.2006","article-title":"Mitochondrial reactive oxygen species-mediated signaling in endothelial cells.","volume":"292","author":"Zhang","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R42-16-20230208","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1046\/j.1523-1755.2003.00906.x","article-title":"Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells.","volume":"63","author":"Motojima","year":"2003","journal-title":"Kidney Int"},{"key":"R43-16-20230208","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.jchromb.2011.06.014","article-title":"Determination of uremic solutes in biological fluids of chronic kidney disease patients by HPLC assay.","volume":"879","author":"Calaf","year":"2011","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"R44-16-20230208","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1172\/JCI107470","article-title":"Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.","volume":"52","author":"Jaffe","year":"1973","journal-title":"J Clin Invest"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201504000-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:24:41Z","timestamp":1786130681000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201504000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2013121283","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}