{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:26:28Z","timestamp":1789950388538,"version":"4.0.1"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1681\/asn.2014010126","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T00:28:02Z","timestamp":1410222482000},"page":"1092-1102","source":"Crossref","is-referenced-by-count":57,"title":["Conditional Knockout of Proximal Tubule Mitofusin 2 Accelerates Recovery and Improves Survival after Renal Ischemia"],"prefix":"10.1681","volume":"26","author":[{"given":"Jonathan M.","family":"Gall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon G.","family":"Bonegio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Havasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Liesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradheep","family":"Vemula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Borkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-14-20230208","doi-asserted-by":"crossref","first-page":"C447","DOI":"10.1152\/ajpcell.00402.2010","article-title":"Fragmented mitochondria are sensitized to Bax insertion and activation during apoptosis.","volume":"300","author":"Brooks","year":"2011","journal-title":"Am J Physiol Cell Physiol"},{"key":"R2-14-20230208","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1089\/rej.2008.0783","article-title":"Over-expression of heat shock protein 70 in mice is associated with growth retardation, tumor formation, and early death.","volume":"11","author":"Vanhooren","year":"2008","journal-title":"Rejuvenation Res"},{"key":"R3-14-20230208","doi-asserted-by":"crossref","first-page":"11649","DOI":"10.1073\/pnas.0703976104","article-title":"Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.","volume":"104","author":"Brooks","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R4-14-20230208","doi-asserted-by":"crossref","first-page":"e31074","DOI":"10.1371\/journal.pone.0031074","article-title":"Role of mitofusin 2 in the renal stress response.","volume":"7","author":"Gall","year":"2012","journal-title":"PLoS ONE"},{"key":"R5-14-20230208","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1172\/JCI37829","article-title":"Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models.","volume":"119","author":"Brooks","year":"2009","journal-title":"J Clin Invest"},{"key":"R6-14-20230208","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1074\/jbc.M607279200","article-title":"Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.","volume":"282","author":"Taguchi","year":"2007","journal-title":"J Biol Chem"},{"key":"R7-14-20230208","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ncb1907","article-title":"Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice.","volume":"11","author":"Ishihara","year":"2009","journal-title":"Nat Cell Biol"},{"key":"R8-14-20230208","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","article-title":"Fission and selective fusion govern mitochondrial segregation and elimination by autophagy.","volume":"27","author":"Twig","year":"2008","journal-title":"EMBO J"},{"key":"R9-14-20230208","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cell.2010.02.026","article-title":"Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.","volume":"141","author":"Chen","year":"2010","journal-title":"Cell"},{"key":"R10-14-20230208","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.1073\/pnas.1108220109","article-title":"Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis.","volume":"109","author":"Sebasti\u00e1n","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R11-14-20230208","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/ncb1161","article-title":"Dysregulation of HSG triggers vascular proliferative disorders.","volume":"6","author":"Chen","year":"2004","journal-title":"Nat Cell Biol"},{"key":"R12-14-20230208","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1096\/fj.13-230037","article-title":"Role of mitofusin 2 (Mfn2) in controlling cellular proliferation.","volume":"28","author":"Chen","year":"2014","journal-title":"FASEB J"},{"key":"R13-14-20230208","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.5301\/jn.5000089","article-title":"Effect of mitofusin 2 overexpression on the proliferation and apoptosis of high-glucose-induced rat glomerular mesangial cells.","volume":"25","author":"Wan-Xin","year":"2012","journal-title":"J Nephrol"},{"key":"R14-14-20230208","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ki.2012.43","article-title":"Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury.","volume":"82","author":"Chen","year":"2012","journal-title":"Kidney Int"},{"key":"R15-14-20230208","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.ejcb.2006.06.001","article-title":"Signal transduction of MEK\/ERK and PI3K\/Akt activation by hypoxia\/reoxygenation in renal epithelial cells.","volume":"85","author":"Kwon","year":"2006","journal-title":"Eur J Cell Biol"},{"key":"R16-14-20230208","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1016\/j.bbadis.2013.07.001","article-title":"Activation of ERK accelerates repair of renal tubular epithelial cells, whereas it inhibits progression of fibrosis following ischemia\/reperfusion injury.","volume":"1832","author":"Jang","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"R17-14-20230208","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1681\/ASN.2009030253","article-title":"Beta-catenin promotes survival of renal epithelial cells by inhibiting Bax.","volume":"20","author":"Wang","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"R18-14-20230208","doi-asserted-by":"crossref","first-page":"F1481","DOI":"10.1152\/ajprenal.00064.2008","article-title":"An androgen-inducible proximal tubule-specific Cre recombinase transgenic model.","volume":"294","author":"Li","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"R19-14-20230208","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1242\/jcs.109.11.2727","article-title":"Dual functions of transglutaminase in novel cell adhesion.","volume":"109","author":"Ueki","year":"1996","journal-title":"J Cell Sci"},{"key":"R20-14-20230208","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1681\/ASN.2009080828","article-title":"GSK3beta promotes apoptosis after renal ischemic injury.","volume":"21","author":"Wang","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"R21-14-20230208","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/ki.2010.527","article-title":"Induction of heat shock protein 70 inhibits ischemic renal injury.","volume":"79","author":"Wang","year":"2011","journal-title":"Kidney Int"},{"key":"R22-14-20230208","doi-asserted-by":"crossref","first-page":"15032","DOI":"10.1074\/jbc.M308734200","article-title":"Cell type-specific activation of intracellular transglutaminase 2 by oxidative stress or ultraviolet irradiation: implications of transglutaminase 2 in age-related cataractogenesis.","volume":"279","author":"Shin","year":"2004","journal-title":"J Biol Chem"},{"key":"R23-14-20230208","doi-asserted-by":"crossref","first-page":"F608","DOI":"10.1152\/ajprenal.00284.2002","article-title":"Cell death induced by acute renal injury: A perspective on the contributions of apoptosis and necrosis.","volume":"284","author":"Padanilam","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"R24-14-20230208","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ki.1978.87","article-title":"Ischemic damage and repair in the rat proximal tubule: Differences among the S1, S2, and S3 segments.","volume":"14","author":"Venkatachalam","year":"1978","journal-title":"Kidney Int"},{"key":"R25-14-20230208","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1046\/j.1523-1755.2001.00930.x","article-title":"Difficulties in understanding human \u201cacute tubular necrosis\u201d: Limited data and flawed animal models.","volume":"60","author":"Rosen","year":"2001","journal-title":"Kidney Int"},{"key":"R26-14-20230208","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1128\/MCB.00911-10","article-title":"Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes.","volume":"31","author":"Papanicolaou","year":"2011","journal-title":"Mol Cell Biol"},{"key":"R27-14-20230208","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1681\/ASN.2006010017","article-title":"Update on mechanisms of ischemic acute kidney injury.","volume":"17","author":"Devarajan","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"R28-14-20230208","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ajpath.2012.09.017","article-title":"Histone acetyl transferase (HAT) HBO1 and JADE1 in epithelial cell regeneration.","volume":"182","author":"Havasi","year":"2013","journal-title":"Am J Pathol"},{"key":"R29-14-20230208","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1172\/JCI22593","article-title":"Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells.","volume":"115","author":"Duffield","year":"2005","journal-title":"J Clin Invest"},{"key":"R30-14-20230208","first-page":"546","article-title":"Dissociation of tubular cell detachment and tubular cell death in clinical and experimental \u201cacute tubular necrosis\u201d.","volume":"64","author":"Racusen","year":"1991","journal-title":"Lab Invest"},{"key":"R31-14-20230208","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000313743","article-title":"Pathophysiology of acute kidney injury: a new perspective.","volume":"165","author":"Wen","year":"2010","journal-title":"Contrib Nephrol"},{"key":"R32-14-20230208","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/stem.310","article-title":"Mouse kidney progenitor cells accelerate renal regeneration and prolong survival after ischemic injury.","volume":"28","author":"Lee","year":"2010","journal-title":"Stem Cells"},{"key":"R33-14-20230208","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2353\/ajpath.2009.080295","article-title":"Inhibition of autoregulated TGFbeta signaling simultaneously enhances proliferation and differentiation of kidney epithelium and promotes repair following renal ischemia.","volume":"174","author":"Geng","year":"2009","journal-title":"Am J Pathol"},{"key":"R34-14-20230208","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1111\/j.1600-6143.2006.01559.x","article-title":"Risk factors for early epithelial to mesenchymal transition in renal grafts.","volume":"6","author":"Hertig","year":"2006","journal-title":"Am J Transplant"},{"key":"R35-14-20230208","first-page":"1334","article-title":"Effects of ulinastatin on renal ischemia-reperfusion injury in rats.","volume":"25","author":"Chen","year":"2004","journal-title":"Acta Pharmacol Sin"},{"key":"R36-14-20230208","doi-asserted-by":"crossref","first-page":"26546","DOI":"10.1016\/S0021-9258(18)47229-8","article-title":"The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion.","volume":"269","author":"Pombo","year":"1994","journal-title":"J Biol Chem"},{"key":"R37-14-20230208","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/01.ASN.0000102470.12285.C6","article-title":"Prevention of acute ischemic renal failure by targeted delivery of growth factors to the proximal tubule in transgenic mice: The efficacy of parathyroid hormone-related protein and hepatocyte growth factor.","volume":"15","author":"Fiaschi-Taesch","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"R38-14-20230208","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0960-9822(99)80192-4","article-title":"Akt\/PKB localisation and 3\u2032 phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction.","volume":"9","author":"Watton","year":"1999","journal-title":"Curr Biol"},{"key":"R39-14-20230208","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1681\/ASN.2004080626","article-title":"Ghrelin improves renal function in mice with ischemic acute renal failure.","volume":"17","author":"Takeda","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"R40-14-20230208","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases.","volume":"298","author":"Johnson","year":"2002","journal-title":"Science"},{"key":"R41-14-20230208","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/j.1523-1755.2004.00500.x","article-title":"Activation of ERK or inhibition of JNK ameliorates H(2)O(2) cytotoxicity in mouse renal proximal tubule cells.","volume":"65","author":"Arany","year":"2004","journal-title":"Kidney Int"},{"key":"R42-14-20230208","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/sj.ki.5001604","article-title":"STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells.","volume":"70","author":"Arany","year":"2006","journal-title":"Kidney Int"},{"key":"R43-14-20230208","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/bbrc.1998.9902","article-title":"Extracellular signal-regulated kinase mediates renal regeneration in rats with myoglobinuric acute renal injury.","volume":"254","author":"Ishizuka","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"R44-14-20230208","doi-asserted-by":"crossref","first-page":"452","DOI":"10.2353\/ajpath.2007.060805","article-title":"Extracellular signal-regulated kinase activation during renal ischemia\/reperfusion mediates focal adhesion dissolution and renal injury.","volume":"171","author":"Alderliesten","year":"2007","journal-title":"Am J Pathol"},{"key":"R45-14-20230208","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/jat.1081","article-title":"Role of ERK activation in cisplatin-induced apoptosis in OK renal epithelial cells.","volume":"25","author":"Kim","year":"2005","journal-title":"J Appl Toxicol"},{"key":"R46-14-20230208","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.bbadis.2013.05.023","article-title":"ERK-mediated suppression of cilia in cisplatin-induced tubular cell apoptosis and acute kidney injury.","volume":"1832","author":"Wang","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"R47-14-20230208","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1083\/jcb.200211046","article-title":"Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development.","volume":"160","author":"Chen","year":"2003","journal-title":"J Cell Biol"},{"key":"R48-14-20230208","doi-asserted-by":"crossref","first-page":"C1483","DOI":"10.1152\/ajpcell.00049.2003","article-title":"HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells.","volume":"285","author":"Ruchalski","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"key":"R49-14-20230208","doi-asserted-by":"crossref","first-page":"C917","DOI":"10.1152\/ajpcell.00517.2001","article-title":"Heat stress prevents mitochondrial injury in ATP-depleted renal epithelial cells.","volume":"283","author":"Li","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"R50-14-20230208","first-page":"F527","article-title":"Hepatic alpha 2 mu-globulin: A potential metabolic role in the rat proximal tubule.","volume":"271","author":"Borkan","year":"1996","journal-title":"Am J Physiol"},{"key":"R51-14-20230208","doi-asserted-by":"crossref","first-page":"7873","DOI":"10.1074\/jbc.M513728200","article-title":"Distinct hsp70 domains mediate apoptosis-inducing factor release and nuclear accumulation.","volume":"281","author":"Ruchalski","year":"2006","journal-title":"J Biol Chem"},{"key":"R52-14-20230208","doi-asserted-by":"crossref","first-page":"C1803","DOI":"10.1152\/ajpcell.1994.266.6.C1803","article-title":"Method for recovering ATP content and mitochondrial function after chemical anoxia in renal cell cultures.","volume":"266","author":"Doctor","year":"1994","journal-title":"Am J Physiol"},{"key":"R53-14-20230208","doi-asserted-by":"crossref","first-page":"F760","DOI":"10.1152\/ajprenal.00052.2009","article-title":"Hsp27 inhibits sublethal, Src-mediated renal epithelial cell injury.","volume":"297","author":"Havasi","year":"2009","journal-title":"Am J Physiol Renal Physiol"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201505000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:25:01Z","timestamp":1786130701000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201505000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2014010126","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}