{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:10:29Z","timestamp":1793261429279,"version":"4.5.0"},"reference-count":62,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1681\/asn.2014040378","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T01:13:39Z","timestamp":1407287619000},"page":"20-29","source":"Crossref","is-referenced-by-count":112,"title":["Through a Glass Darkly"],"prefix":"10.1681","volume":"26","author":[{"given":"Mark D.","family":"Stegall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Gaston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando G.","family":"Cosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Matas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20230208","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1600-6143.2010.03283.x","article-title":"Long-term renal allograft survival in the United States: A critical reappraisal.","volume":"11","author":"Lamb","year":"2011","journal-title":"Am J Transplant"},{"key":"R3-7-20230208","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/ki.1991.240","article-title":"Histopathologic findings associated with a chronic, progressive decline in renal allograft function.","volume":"40","author":"Kasiske","year":"1991","journal-title":"Kidney Int"},{"key":"R4-7-20230208","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1399-0012.1994.tb00263.x","article-title":"Acute rejection episodes\u2014best predictor of long-term primary cadaveric renal transplant survival.","volume":"8","author":"Ferguson","year":"1994","journal-title":"Clin Transplant"},{"key":"R5-7-20230208","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev.med.58.061705.145143","article-title":"Why hasn\u2019t eliminating acute rejection improved graft survival?","volume":"58","author":"Tantravahi","year":"2007","journal-title":"Annu Rev Med"},{"key":"R6-7-20230208","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJM198409133111103","article-title":"Cyclosporine-associated chronic nephropathy.","volume":"311","author":"Myers","year":"1984","journal-title":"N Engl J Med"},{"key":"R7-7-20230208","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1056\/NEJMoa020009","article-title":"The natural history of chronic allograft nephropathy.","volume":"349","author":"Nankivell","year":"2003","journal-title":"N Engl J Med"},{"key":"R8-7-20230208","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/01.TP.0000128636.70499.6E","article-title":"Calcineurin inhibitor nephrotoxicity: Longitudinal assessment by protocol histology.","volume":"78","author":"Nankivell","year":"2004","journal-title":"Transplantation"},{"key":"R9-7-20230208","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5500\/wjt.v3.i2.7","article-title":"Is it time to give up with calcineurin inhibitors in kidney transplantation?","volume":"3","author":"Salvadori","year":"2013","journal-title":"World J Transplant"},{"key":"R10-7-20230208","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1097\/00007890-200212150-00013","article-title":"Improved renal function in sirolimus-treated renal transplant patients after early cyclosporine elimination.","volume":"74","author":"Gonwa","year":"2002","journal-title":"Transplantation"},{"key":"R11-7-20230208","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1097\/01.tp.0000258586.52777.4c","article-title":"Kidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugs.","volume":"83","author":"Flechner","year":"2007","journal-title":"Transplantation"},{"key":"R12-7-20230208","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1600-6143.2005.01177.x","article-title":"Complete avoidance of calcineurin inhibitors in renal transplantation: A randomized trial comparing sirolimus and tacrolimus.","volume":"6","author":"Larson","year":"2006","journal-title":"Am J Transplant"},{"key":"R13-7-20230208","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1097\/TP.0b013e3181db09e4","article-title":"Thymoglobulin induction and sirolimus versus tacrolimus in kidney transplant recipients receiving mycophenolate mofetil and steroids.","volume":"89","author":"Glotz","year":"2010","journal-title":"Transplantation"},{"key":"R14-7-20230208","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/j.1600-6143.2011.03573.x","article-title":"The ORION study: Comparison of two sirolimus-based regimens versus tacrolimus and mycophenolate mofetil in renal allograft recipients.","volume":"11","author":"Flechner","year":"2011","journal-title":"Am J Transplant"},{"key":"R15-7-20230208","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1056\/NEJMoa067411","article-title":"Reduced exposure to calcineurin inhibitors in renal transplantation.","volume":"357","author":"Ekberg","year":"2007","journal-title":"N Engl J Med"},{"key":"R16-7-20230208","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1600-6143.2009.02943.x","article-title":"Histopathologic clusters differentiate subgroups within the nonspecific diagnoses of CAN or CR: Preliminary data from the DeKAF study.","volume":"10","author":"Matas","year":"2010","journal-title":"Am J Transplant"},{"key":"R17-7-20230208","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1399-0012.2007.00647.x","article-title":"Acute rejection in non-compliant renal allograft recipients: A distinct morphology.","volume":"21","author":"Lerut","year":"2007","journal-title":"Clin Transplant"},{"key":"R18-7-20230208","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1600-6143.2009.03005.x","article-title":"A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study).","volume":"10","author":"Vincenti","year":"2010","journal-title":"Am J Transplant"},{"key":"R19-7-20230208","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1600-6143.2008.02519.x","article-title":"Identifying specific causes of kidney allograft loss.","volume":"9","author":"El-Zoghby","year":"2009","journal-title":"Am J Transplant"},{"key":"R20-7-20230208","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/j.1600-6143.2010.03312.x","article-title":"The histology of solitary renal allografts at 1 and 5 years after transplantation.","volume":"11","author":"Stegall","year":"2011","journal-title":"Am J Transplant"},{"key":"R21-7-20230208","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1097\/TP.0b013e3182692b70","article-title":"Identification and characterization of kidney transplants with good glomerular filtration rate at 1 year but subsequent progressive loss of renal function.","volume":"94","author":"Park","year":"2012","journal-title":"Transplantation"},{"key":"R22-7-20230208","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1097\/01.ASN.0000056189.02819.32","article-title":"The impact of repeated subclinical acute rejection on the progression of chronic allograft nephropathy.","volume":"14","author":"Shishido","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"R23-7-20230208","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1111\/j.1600-6143.2005.01050.x","article-title":"Predicting subsequent decline in kidney allograft function from early surveillance biopsies.","volume":"5","author":"Cosio","year":"2005","journal-title":"Am J Transplant"},{"key":"R24-7-20230208","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1600-6143.2005.01230.x","article-title":"Subclinical rejection associated with chronic allograft nephropathy in protocol biopsies as a risk factor for late graft loss.","volume":"6","author":"Moreso","year":"2006","journal-title":"Am J Transplant"},{"key":"R25-7-20230208","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/ctr.12201","article-title":"Delayed allograft inflammation following alemtuzumab induction for kidney transplantation.","volume":"27","author":"Heilman","year":"2013","journal-title":"Clin Transplant"},{"key":"R26-7-20230208","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1600-6143.2012.04304.x","article-title":"Chronic histological damage in early indication biopsies is an independent risk factor for late renal allograft failure.","volume":"13","author":"Naesens","year":"2013","journal-title":"Am J Transplant"},{"key":"R27-7-20230208","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1681\/ASN.2010010049","article-title":"Fibrosis with inflammation at one year predicts transplant functional decline.","volume":"21","author":"Park","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"R28-7-20230208","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1111\/ajt.12370","article-title":"Kidney allograft survival after acute rejection, the value of follow-up biopsies.","volume":"13","author":"El Ters","year":"2013","journal-title":"Am J Transplant"},{"key":"R29-7-20230208","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/j.1600-6143.2011.03903.x","article-title":"The pathology and clinical features of early recurrent membranous glomerulonephritis.","volume":"12","author":"Rodriguez","year":"2012","journal-title":"Am J Transplant"},{"key":"R30-7-20230208","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/TP.0b013e3181e065de","article-title":"Evidence for antibody-mediated injury as a major determinant of late kidney allograft failure.","volume":"90","author":"Gaston","year":"2010","journal-title":"Transplantation"},{"key":"R31-7-20230208","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1600-6143.2011.03840.x","article-title":"Understanding the causes of kidney transplant failure: The dominant role of antibody-mediated rejection and nonadherence.","volume":"12","author":"Sellar\u00e9s","year":"2012","journal-title":"Am J Transplant"},{"key":"R33-7-20230208","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.humimm.2009.04.019","article-title":"Monitoring and treating posttransplant human leukocyte antigen antibodies.","volume":"70","author":"Everly","year":"2009","journal-title":"Hum Immunol"},{"key":"R34-7-20230208","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1034\/j.1600-6143.2003.00171.x","article-title":"Complement C4d in graft capillaries \u2014 the missing link in the recognition of humoral alloreactivity.","volume":"3","author":"Feucht","year":"2003","journal-title":"Am J Transplant"},{"key":"R35-7-20230208","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1111\/j.1600-6143.2009.02813.x","article-title":"Outcome of subclinical antibody-mediated rejection in kidney transplant recipients with preformed donor-specific antibodies.","volume":"9","author":"Loupy","year":"2009","journal-title":"Am J Transplant"},{"key":"R36-7-20230208","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/ajt.12150","article-title":"Molecular diagnosis of antibody-mediated rejection in human kidney transplants.","volume":"13","author":"Sellar\u00e9s","year":"2013","journal-title":"Am J Transplant"},{"key":"R37-7-20230208","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/MOT.0b013e32833b9c11","article-title":"The (re)emergence of B cells in organ transplantation.","volume":"15","author":"Stegall","year":"2010","journal-title":"Curr Opin Organ Transplant"},{"key":"R38-7-20230208","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1681\/ASN.2004121130","article-title":"Frequency and clinical implications of development of donor-specific and non-donor-specific HLA antibodies after kidney transplantation.","volume":"16","author":"Hourmant","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"R39-7-20230208","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1600-6143.2012.04013.x","article-title":"Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant.","volume":"12","author":"Wiebe","year":"2012","journal-title":"Am J Transplant"},{"key":"R40-7-20230208","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/TP.0b013e31827d62e3","article-title":"Incidence and impact of de novo donor-specific alloantibody in primary renal allografts.","volume":"95","author":"Everly","year":"2013","journal-title":"Transplantation"},{"key":"R41-7-20230208","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1111\/j.1600-6143.2009.02727.x","article-title":"Scoring total inflammation is superior to the current Banff inflammation score in predicting outcome and the degree of molecular disturbance in renal allografts.","volume":"9","author":"Mengel","year":"2009","journal-title":"Am J Transplant"},{"key":"R42-7-20230208","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1111\/j.1600-6143.2010.03240.x","article-title":"Inflammation in areas of tubular atrophy in kidney allograft biopsies: A potent predictor of allograft failure.","volume":"10","author":"Mannon","year":"2010","journal-title":"Am J Transplant"},{"key":"R43-7-20230208","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1111\/j.1600-6143.2009.02761.x","article-title":"Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining.","volume":"9","author":"Sis","year":"2009","journal-title":"Am J Transplant"},{"key":"R44-7-20230208","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/ki.2013.300","article-title":"Antibody-mediated rejection, T cell-mediated rejection and the injury-repair response: New insights from the Genome Canada studies of kidney transplant biopsies.","volume":"85","author":"Halloran","year":"2014","journal-title":"Kidney Int"},{"key":"R45-7-20230208","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s11255-014-0655-8","article-title":"Effect of donor-recipient age difference on long-term graft survival in living kidney transplantation.","volume":"46","author":"Tasaki","year":"2014","journal-title":"Int Urol Nephrol"},{"key":"R46-7-20230208","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/TP.0b013e318277b2be","article-title":"Outcomes of kidney transplantation from older living donors.","volume":"95","author":"Lim","year":"2013","journal-title":"Transplantation"},{"key":"R47-7-20230208","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.1073\/pnas.1101148108","article-title":"Ectopic B-cell clusters that infiltrate transplanted human kidneys are clonal.","volume":"108","author":"Cheng","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R48-7-20230208","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/gm253","article-title":"Biomarkers in solid organ transplantation: Establishing personalized transplantation medicine.","volume":"3","author":"Roedder","year":"2011","journal-title":"Genome Med"},{"key":"R49-7-20230208","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrneph.2013.281","article-title":"Biomarkers for kidney transplant rejection.","volume":"10","author":"Lo","year":"2014","journal-title":"Nat Rev Nephrol"},{"key":"R50-7-20230208","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.cca.2012.04.014","article-title":"Cytokines as predictive biomarkers of alloreactivity.","volume":"413","author":"Brunet","year":"2012","journal-title":"Clin Chim Acta"},{"key":"R51-7-20230208","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/ki.2013.200","article-title":"Serum aminoacylase-1 is a novel biomarker with potential prognostic utility for long-term outcome in patients with delayed graft function following renal transplantation.","volume":"84","author":"Welberry Smith","year":"2013","journal-title":"Kidney Int"},{"key":"R52-7-20230208","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/ki.2013.172","article-title":"Serum \u03b22-microglobulin at discharge predicts mortality and graft loss following kidney transplantation.","volume":"84","author":"Astor","year":"2013","journal-title":"Kidney Int"},{"key":"R53-7-20230208","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1111\/ajt.12426","article-title":"Multicenter validation of urinary CXCL9 as a risk-stratifying biomarker for kidney transplant injury.","volume":"13","author":"Hricik","year":"2013","journal-title":"Am J Transplant"},{"key":"R54-7-20230208","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/TP.0b013e31826690fd","article-title":"Increased urinary CCL2: Cr ratio at 6 months is associated with late renal allograft loss.","volume":"95","author":"Ho","year":"2013","journal-title":"Transplantation"},{"key":"R55-7-20230208","doi-asserted-by":"crossref","first-page":"e60702","DOI":"10.1371\/journal.pone.0060702","article-title":"Expression of miR-142-5p in peripheral blood mononuclear cells from renal transplant patients with chronic antibody-mediated rejection.","volume":"8","author":"Danger","year":"2013","journal-title":"PLoS ONE"},{"key":"R56-7-20230208","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1681\/ASN.2007101056","article-title":"Tribbles-1 as a novel biomarker of chronic antibody-mediated rejection.","volume":"19","author":"Ashton-Chess","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"R57-7-20230208","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1111\/j.1600-6143.2012.04253.x","article-title":"A peripheral blood diagnostic test for acute rejection in renal transplantation.","volume":"12","author":"Li","year":"2012","journal-title":"Am J Transplant"},{"key":"R58-7-20230208","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.molimm.2013.01.013","article-title":"Kidney injury molecule-1 and osteopontin: New markers for prediction of early kidney transplant rejection.","volume":"54","author":"Jin","year":"2013","journal-title":"Mol Immunol"},{"key":"R59-7-20230208","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/1354750X.2013.867536","article-title":"Urinary neutrophil gelatinase-associated lipocalin predicts graft loss after acute kidney injury in kidney transplant.","volume":"19","author":"Ram\u00edrez-Sandoval","year":"2014","journal-title":"Biomarkers"},{"key":"R60-7-20230208","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1046\/j.1600-6135.2003.00275.x","article-title":"Poor predictive value of serum creatinine for renal allograft loss.","volume":"3","author":"Kaplan","year":"2003","journal-title":"Am J Transplant"},{"key":"R61-7-20230208","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1056\/NEJMoa1302506","article-title":"Complement-binding anti-HLA antibodies and kidney-allograft survival.","volume":"369","author":"Loupy","year":"2013","journal-title":"N Engl J Med"},{"key":"R62-7-20230208","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/978-1-62703-493-7_16","article-title":"C1q assay for the detection of complement fixing antibody to HLA antigens.","volume":"1034","author":"Chen","year":"2013","journal-title":"Methods Mol Biol"},{"key":"R63-7-20230208","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1111\/j.1600-6143.2010.03201.x","article-title":"NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: Evidence for NK cell involvement in antibody-mediated rejection.","volume":"10","author":"Hidalgo","year":"2010","journal-title":"Am J Transplant"},{"key":"R64-7-20230208","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1111\/ajt.12465","article-title":"Microarray diagnosis of antibody-mediated rejection in kidney transplant biopsies: An international prospective study (INTERCOM).","volume":"13","author":"Halloran","year":"2013","journal-title":"Am J Transplant"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201501000-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:45:06Z","timestamp":1786131906000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201501000-00007"}},"subtitle":["Seeking Clarity in Preventing Late Kidney Transplant Failure"],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2014040378","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}