{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:02:04Z","timestamp":1786132924742,"version":"build-2736575974"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1681\/asn.2014050485","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T22:53:05Z","timestamp":1426719185000},"page":"2659-2668","source":"Crossref","is-referenced-by-count":50,"title":["Zinc-\u03b12-Glycoprotein Exerts Antifibrotic Effects in Kidney and Heart"],"prefix":"10.1681","volume":"26","author":[{"given":"Inga","family":"S\u00f6rensen-Zender","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar","family":"Bhayana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Susnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Rolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandor","family":"Batkai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpita","family":"Baisantry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siamak","family":"Bahram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payel","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beina","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Schiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Thum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Melk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Haller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20230208","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/MNH.0b013e3283521cfa","article-title":"Renal interstitial fibrosis: Mechanisms and evaluation.","volume":"21","author":"Farris","year":"2012","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"R2-12-20230208","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1681\/ASN.2008010035","article-title":"Zag expression during aging suppresses proliferation after kidney injury.","volume":"19","author":"Schmitt","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"R3-12-20230208","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0021-9258(18)64243-7","article-title":"Preparation and properties of Zn-alpha 2-glycoprotein of normal human plasma.","volume":"236","author":"Burgi","year":"1961","journal-title":"J Biol Chem"},{"key":"R4-12-20230208","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1158\/1541-7786.MCR-07-2195","article-title":"Zinc alpha 2-glycoprotein: A multidisciplinary protein.","volume":"6","author":"Hassan","year":"2008","journal-title":"Mol Cancer Res"},{"key":"R5-12-20230208","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.febslet.2006.12.047","article-title":"Lipolysis is altered in MHC class I zinc-alpha(2)-glycoprotein deficient mice.","volume":"581","author":"Rolli","year":"2007","journal-title":"FEBS Lett"},{"key":"R6-12-20230208","first-page":"2359","article-title":"Biological evaluation of a lipid-mobilizing factor isolated from the urine of cancer patients.","volume":"58","author":"Hirai","year":"1998","journal-title":"Cancer Res"},{"key":"R7-12-20230208","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.bbalip.2011.12.003","article-title":"Role of \u03b2-adrenergic receptors in the anti-obesity and anti-diabetic effects of zinc-\u03b12-glycoprotien (ZAG).","volume":"1821","author":"Russell","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"R8-12-20230208","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1073\/pnas.0308647100","article-title":"Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia.","volume":"101","author":"Bing","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R9-12-20230208","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1210\/en.2010-0532","article-title":"Mechanism of attenuation of skeletal muscle atrophy by zinc-alpha2-glycoprotein.","volume":"151","author":"Russell","year":"2010","journal-title":"Endocrinology"},{"key":"R10-12-20230208","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1172\/JCI108371","article-title":"Renal handling of Zn-alpha2-glycoprotein as compared with that of albumin and the retinol-binding protein.","volume":"57","author":"Ekman","year":"1976","journal-title":"J Clin Invest"},{"key":"R11-12-20230208","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.3109\/0886022X.2012.712859","article-title":"Zinc-\u03b12-glycoprotein: Is there association between this new adipokine and body composition in hemodialysis patients?","volume":"34","author":"Leal","year":"2012","journal-title":"Ren Fail"},{"key":"R12-12-20230208","first-page":"669","article-title":"Serum levels of the adipokine zinc-\u03b12-glycoprotein are increased in chronic hemodialysis.","volume":"60","author":"Philipp","year":"2011","journal-title":"Metabolism"},{"key":"R13-12-20230208","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1471-2369-14-145","article-title":"Zinc-alpha2-glycoprotein in patients with acute and chronic kidney disease.","volume":"14","author":"S\u00f6rensen-Zender","year":"2013","journal-title":"BMC Nephrol"},{"key":"R14-12-20230208","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/ki.2013.9","article-title":"White adipose tissue overproduces the lipid-mobilizing factor zinc \u03b12-glycoprotein in chronic kidney disease.","volume":"83","author":"Pelletier","year":"2013","journal-title":"Kidney Int"},{"key":"R15-12-20230208","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.cca.2011.12.002","article-title":"Is zinc-\u03b12-glycoprotein a cardiovascular protective factor for patients undergoing hemodialysis?","volume":"413","author":"Leal","year":"2012","journal-title":"Clin Chim Acta"},{"key":"R16-12-20230208","doi-asserted-by":"crossref","first-page":"C216","DOI":"10.1152\/ajpcell.00328.2012","article-title":"Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis.","volume":"304","author":"Zeisberg","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"key":"R17-12-20230208","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.7150\/ijbs.7.1056","article-title":"Diverse roles of TGF-\u03b2\/Smads in renal fibrosis and inflammation.","volume":"7","author":"Lan","year":"2011","journal-title":"Int J Biol Sci"},{"key":"R18-12-20230208","doi-asserted-by":"crossref","first-page":"632","DOI":"10.2353\/ajpath.2010.091012","article-title":"Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells.","volume":"177","author":"Koesters","year":"2010","journal-title":"Am J Pathol"},{"key":"R19-12-20230208","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/MNH.0b013e3283046507","article-title":"Epithelial-mesenchymal-epithelial cycling in kidney repair.","volume":"17","author":"Ishibe","year":"2008","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"R20-12-20230208","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1073\/pnas.0304146101","article-title":"Gene expression profiling identifies clinically relevant subtypes of prostate cancer.","volume":"101","author":"Lapointe","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R21-12-20230208","doi-asserted-by":"crossref","first-page":"e69155","DOI":"10.1371\/journal.pone.0069155","article-title":"Decreased expression of AZGP1 is associated with poor prognosis in primary gastric cancer.","volume":"8","author":"Huang","year":"2013","journal-title":"PLoS ONE"},{"key":"R22-12-20230208","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/ijc.28497","article-title":"Additive effect of the AZGP1, PIP, S100A8 and UBE2C molecular biomarkers improves outcome prediction in breast carcinoma.","volume":"134","author":"Parris","year":"2014","journal-title":"Int J Cancer"},{"key":"R23-12-20230208","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0304-3835(98)00347-4","article-title":"Zinc-alpha2-glycoprotein expression as a marker of differentiation in human oral tumors.","volume":"137","author":"Brysk","year":"1999","journal-title":"Cancer Lett"},{"key":"R24-12-20230208","doi-asserted-by":"crossref","first-page":"5146","DOI":"10.1038\/onc.2010.258","article-title":"AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-\u03b2-mediated ERK signaling.","volume":"29","author":"Kong","year":"2010","journal-title":"Oncogene"},{"key":"R25-12-20230208","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1210\/en.2012-1260","article-title":"Role of \u03b2-adrenergic receptors in the oral activity of zinc-\u03b12-glycoprotein (ZAG).","volume":"153","author":"Russell","year":"2012","journal-title":"Endocrinology"},{"key":"R26-12-20230208","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/path.1398","article-title":"Role of tissue stroma in cancer cell invasion.","volume":"200","author":"De Wever","year":"2003","journal-title":"J Pathol"},{"key":"R27-12-20230208","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/j.1523-1755.2005.00486.x","article-title":"Obstructive nephropathy: Insights from genetically engineered animals.","volume":"68","author":"Bascands","year":"2005","journal-title":"Kidney Int"},{"key":"R28-12-20230208","doi-asserted-by":"crossref","first-page":"F1006","DOI":"10.1152\/ajprenal.00675.2009","article-title":"Mechanism of chronic aristolochic acid nephropathy: Role of Smad3.","volume":"298","author":"Zhou","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"R29-12-20230208","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00418-008-0541-5","article-title":"Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload.","volume":"131","author":"Xia","year":"2009","journal-title":"Histochem Cell Biol"},{"key":"R30-12-20230208","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s10585-007-9118-2","article-title":"TGF-beta and BMP7 interactions in tumour progression and bone metastasis.","volume":"24","author":"Buijs","year":"2007","journal-title":"Clin Exp Metastasis"},{"key":"R31-12-20230208","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1210\/jc.2009-0758","article-title":"Lower zinc-alpha2-glycoprotein production by adipose tissue and liver in obese patients unrelated to insulin resistance.","volume":"94","author":"Selva","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"R32-12-20230208","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/ijo.2009.141","article-title":"Zinc-alpha2-glycoprotein is involved in regulation of body weight through inhibition of lipogenic enzymes in adipose tissue.","volume":"33","author":"Gong","year":"2009","journal-title":"Int J Obes (Lond"},{"key":"R33-12-20230208","doi-asserted-by":"crossref","first-page":"374090","DOI":"10.1155\/2014\/374090","article-title":"Serum levels of the adipokine zinc- \u03b1 2-glycoprotein are decreased in patients with hypertension.","volume":"2014","author":"Zhu","year":"2014","journal-title":"ISRN Endocrinol"},{"key":"R34-12-20230208","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1468-1293.2011.00976.x","article-title":"Zinc alpha-2 glycoprotein is implicated in dyslipidaemia in HIV-1-infected patients treated with antiretroviral drugs.","volume":"13","author":"Ceperuelo-Mallafr\u00e9","year":"2012","journal-title":"HIV Med"},{"key":"R35-12-20230208","first-page":"562","article-title":"Serum levels of the adipokine zinc-\u03b12-glycoprotein are increased in preeclampsia.","volume":"35","author":"Stepan","year":"2012","journal-title":"J Endocrinol Invest"},{"key":"R36-12-20230208","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.metabol.2011.05.011","article-title":"Serum adipokine zinc \u03b12-glycoprotein and lipolysis in cachectic and noncachectic heart failure patients: Relationship with neurohormonal and inflammatory biomarkers.","volume":"61","author":"Tedeschi","year":"2012","journal-title":"Metabolism"},{"key":"R37-12-20230208","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1373\/clinchem.2007.089144","article-title":"Novel serum biomarker candidates for liver fibrosis in hepatitis C patients.","volume":"53","author":"Gangadharan","year":"2007","journal-title":"Clin Chem"},{"key":"R38-12-20230208","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/sdi.12197","article-title":"Hemodialysis-associated cardiomyopathy: A newly defined disease entity.","volume":"27","author":"McIntyre","year":"2014","journal-title":"Semin Dial"},{"key":"R39-12-20230208","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1093\/ndt\/gfs050","article-title":"FGF23 and PTH\u2014double agents at the heart of CKD.","volume":"27","author":"Silver","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"R40-12-20230208","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1530\/JOE-12-0402","article-title":"Contrasts between the effects of zinc-\u03b12-glycoprotein, a putative \u03b23\/2-adrenoceptor agonist and the \u03b23\/2-adrenoceptor agonist BRL35135 in C57Bl\/6 (ob\/ob) mice.","volume":"216","author":"Wargent","year":"2013","journal-title":"J Endocrinol"},{"key":"R41-12-20230208","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ki.2011.214","article-title":"Fibrinogen acting as a mitogen for tubulointerstitial fibroblasts, promotes renal fibrosis.","volume":"80","author":"S\u00f6rensen","year":"2011","journal-title":"Kidney Int"},{"key":"R42-12-20230208","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/ki.2013.525","article-title":"Ablation of proximal tubular suppressor of cytokine signaling 3 enhances tubular cell cycling and modifies macrophage phenotype during acute kidney injury.","volume":"85","author":"Susnik","year":"2014","journal-title":"Kidney Int"},{"key":"R43-12-20230208","doi-asserted-by":"crossref","first-page":"8277","DOI":"10.1073\/pnas.88.18.8277","article-title":"Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy.","volume":"88","author":"Rockman","year":"1991","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201511000-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:26:08Z","timestamp":1786130768000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201511000-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2014050485","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725395820.793511467","asserted-by":"object"}]},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]}}}