{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:02:13Z","timestamp":1786132933858,"version":"build-2736575974"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1681\/asn.2014070658","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T21:23:22Z","timestamp":1428355402000},"page":"2678-2690","source":"Crossref","is-referenced-by-count":24,"title":["Caveolin-1 Deficiency Inhibits the Basolateral K+ Channels in the Distal Convoluted Tubule and Impairs Renal K+ and Mg2+ Transport"],"prefix":"10.1681","volume":"26","author":[{"given":"Lijun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengbiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao-Hong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-14-20230208","doi-asserted-by":"crossref","first-page":"F161","DOI":"10.1152\/ajprenal.2000.279.1.F161","article-title":"Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: A new model for ions and diuretics interaction.","volume":"279","author":"Monroy","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"R2-14-20230208","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/ng0196-24","article-title":"Gitelman\u2019s variant of Bartter\u2019s syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter.","volume":"12","author":"Simon","year":"1996","journal-title":"Nat Genet"},{"key":"R3-14-20230208","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1085\/jgp.200208737","article-title":"A chloride channel at the basolateral membrane of the distal-convoluted tubule: A candidate ClC-K channel.","volume":"121","author":"Lourdel","year":"2003","journal-title":"J Gen Physiol"},{"key":"R4-14-20230208","doi-asserted-by":"crossref","first-page":"C1432","DOI":"10.1152\/ajpcell.1998.275.6.C1432","article-title":"K-Cl cotransporter expression in the human kidney.","volume":"275","author":"Liapis","year":"1998","journal-title":"Am J Physiol"},{"key":"R5-14-20230208","first-page":"F546","article-title":"Thiazide-sensitive sodium chloride cotransport in early distal tubule.","volume":"253","author":"Ellison","year":"1987","journal-title":"Am J Physiol"},{"key":"R6-14-20230208","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1152\/physrev.00051.2003","article-title":"Molecular diversity and regulation of renal potassium channels.","volume":"85","author":"Hebert","year":"2005","journal-title":"Physiol Rev"},{"key":"R7-14-20230208","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev.physiol.59.1.413","article-title":"Renal K+ channels: Structure and function.","volume":"59","author":"Wang","year":"1997","journal-title":"Annu Rev Physiol"},{"key":"R8-14-20230208","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1113\/jphysiol.2001.012961","article-title":"An inward rectifier K(+) channel at the basolateral membrane of the mouse distal convoluted tubule: Similarities with Kir4-Kir5.1 heteromeric channels.","volume":"538","author":"Lourdel","year":"2002","journal-title":"J Physiol"},{"key":"R9-14-20230208","doi-asserted-by":"crossref","first-page":"26135","DOI":"10.1074\/jbc.M113.478453","article-title":"Src family protein tyrosine kinase regulates the basolateral K channel in the distal convoluted tubule (DCT) by phosphorylation of KCNJ10 protein.","volume":"288","author":"Zhang","year":"2013","journal-title":"J Biol Chem"},{"key":"R10-14-20230208","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1681\/ASN.2009121227","article-title":"Molecular basis of decreased Kir4.1 function in SeSAME\/EAST syndrome.","volume":"21","author":"Williams","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"R11-14-20230208","doi-asserted-by":"crossref","first-page":"F1398","DOI":"10.1152\/ajprenal.00288.2007","article-title":"Kir4.1\/Kir5.1 channel forms the major K+ channel in the basolateral membrane of mouse renal collecting duct principal cells.","volume":"294","author":"Lachheb","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"R12-14-20230208","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1074\/jbc.M110.160390","article-title":"Calcium-sensing receptor decreases cell surface expression of the inwardly rectifying K+ channel Kir4.1.","volume":"286","author":"Cha","year":"2011","journal-title":"J Biol Chem"},{"key":"R13-14-20230208","doi-asserted-by":"crossref","first-page":"11864","DOI":"10.1073\/pnas.1411705111","article-title":"KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1).","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R14-14-20230208","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1056\/NEJMoa0810276","article-title":"Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations.","volume":"360","author":"Bockenhauer","year":"2009","journal-title":"N Engl J Med"},{"key":"R15-14-20230208","doi-asserted-by":"crossref","first-page":"5842","DOI":"10.1073\/pnas.0901749106","article-title":"Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME syndrome) caused by mutations in KCNJ10.","volume":"106","author":"Scholl","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R16-14-20230208","doi-asserted-by":"crossref","first-page":"14490","DOI":"10.1073\/pnas.1003072107","article-title":"KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function.","volume":"107","author":"Reichold","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R17-14-20230208","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1523\/JNEUROSCI.21-15-05429.2001","article-title":"Kir4.1 potassium channel subunit is crucial for oligodendrocyte development and in vivo myelination.","volume":"21","author":"Neusch","year":"2001","journal-title":"J Neurosci"},{"key":"R18-14-20230208","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1152\/physrev.00046.2003","article-title":"Role of caveolae and caveolins in health and disease.","volume":"84","author":"Cohen","year":"2004","journal-title":"Physiol Rev"},{"key":"R19-14-20230208","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1177\/002215549804600209","article-title":"Basolateral distribution of caveolin-1 in the kidney. Absence from H+-atpase-coated endocytic vesicles in intercalated cells.","volume":"46","author":"Breton","year":"1998","journal-title":"J Histochem Cytochem"},{"key":"R20-14-20230208","doi-asserted-by":"crossref","first-page":"F257","DOI":"10.1152\/ajprenal.00075.2009","article-title":"Unaltered size selectivity of the glomerular filtration barrier in caveolin-1 knockout mice.","volume":"297","author":"Gr\u00e4nde","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"R21-14-20230208","doi-asserted-by":"crossref","first-page":"14849","DOI":"10.1073\/pnas.0702810104","article-title":"Renal expression of parvalbumin is critical for NaCl handling and response to diuretics.","volume":"104","author":"Belge","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R22-14-20230208","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev.cellbio.13.1.513","article-title":"Cellular functions regulated by Src family kinases.","volume":"13","author":"Thomas","year":"1997","journal-title":"Annu Rev Cell Dev Biol"},{"key":"R23-14-20230208","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1073\/pnas.242735399","article-title":"Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4.","volume":"100","author":"Wilson","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R24-14-20230208","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/ng1877","article-title":"Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule.","volume":"38","author":"Lalioti","year":"2006","journal-title":"Nat Genet"},{"key":"R25-14-20230208","doi-asserted-by":"crossref","first-page":"10361","DOI":"10.1073\/pnas.1101400108","article-title":"Renal phenotype in mice lacking the Kir5.1 (Kcnj16) K+ channel subunit contrasts with that observed in SeSAME\/EAST syndrome.","volume":"108","author":"Paulais","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R26-14-20230208","doi-asserted-by":"crossref","first-page":"ra41","DOI":"10.1126\/scisignal.2005050","article-title":"Chloride sensing by WNK1 involves inhibition of autophosphosphorylation.","volume":"7","author":"Piala","year":"2014","journal-title":"Sci Signal"},{"key":"R27-14-20230208","doi-asserted-by":"crossref","first-page":"8458","DOI":"10.1073\/pnas.0802966105","article-title":"Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.","volume":"105","author":"Ponce-Coria","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R28-14-20230208","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1073\/pnas.0813238106","article-title":"Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway.","volume":"106","author":"San-Cristobal","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R29-14-20230208","doi-asserted-by":"crossref","first-page":"50812","DOI":"10.1074\/jbc.M208108200","article-title":"Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).","volume":"277","author":"Piechotta","year":"2002","journal-title":"J Biol Chem"},{"key":"R30-14-20230208","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.cmet.2011.07.009","article-title":"A SPAK isoform switch modulates renal salt transport and blood pressure.","volume":"14","author":"McCormick","year":"2011","journal-title":"Cell Metab"},{"key":"R31-14-20230208","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/HYPERTENSIONAHA.114.03335","article-title":"Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension.","volume":"64","author":"Terker","year":"2014","journal-title":"Hypertension"},{"key":"R32-14-20230208","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1172\/JCI24134","article-title":"Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia.","volume":"115","author":"Nijenhuis","year":"2005","journal-title":"J Clin Invest"},{"key":"R33-14-20230208","doi-asserted-by":"crossref","first-page":"41295","DOI":"10.1074\/jbc.R200020200","article-title":"Multiple functions of caveolin-1.","volume":"277","author":"Liu","year":"2002","journal-title":"J Biol Chem"},{"key":"R34-14-20230208","doi-asserted-by":"crossref","first-page":"29855","DOI":"10.1074\/jbc.M704738200","article-title":"Caveolin-1 regulates the delivery and endocytosis of the glutamate transporter, excitatory amino acid carrier 1.","volume":"282","author":"Gonz\u00e1lez","year":"2007","journal-title":"J Biol Chem"},{"key":"R35-14-20230208","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1681\/ASN.2010090927","article-title":"MicroRNA 802 stimulates ROMK channels by suppressing caveolin-1.","volume":"22","author":"Lin","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"R36-14-20230208","doi-asserted-by":"crossref","first-page":"F1073","DOI":"10.1152\/ajprenal.00269.2006","article-title":"Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function.","volume":"292","author":"Huang","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"R37-14-20230208","doi-asserted-by":"crossref","first-page":"29182","DOI":"10.1074\/jbc.271.46.29182","article-title":"Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases.","volume":"271","author":"Li","year":"1996","journal-title":"J Biol Chem"},{"key":"R38-14-20230208","doi-asserted-by":"crossref","first-page":"9690","DOI":"10.1074\/jbc.271.16.9690","article-title":"Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains.","volume":"271","author":"Song","year":"1996","journal-title":"J Biol Chem"},{"key":"R39-14-20230208","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1096\/fj.03-1391com","article-title":"Caveolae compartmentalization of heme oxygenase-1 in endothelial cells.","volume":"18","author":"Kim","year":"2004","journal-title":"FASEB J"},{"key":"R40-14-20230208","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1681\/ASN.2009121295","article-title":"SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction.","volume":"21","author":"Yang","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"R41-14-20230208","doi-asserted-by":"crossref","first-page":"13347","DOI":"10.1074\/jbc.M113.543710","article-title":"Phosphorylation decreases ubiquitylation of the thiazide-sensitive cotransporter NCC and subsequent clathrin-mediated endocytosis.","volume":"289","author":"Rosenbaek","year":"2014","journal-title":"J Biol Chem"},{"key":"R42-14-20230208","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S0002-9440(10)63920-X","article-title":"Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis.","volume":"162","author":"Cao","year":"2003","journal-title":"Am J Pathol"},{"key":"R43-14-20230208","doi-asserted-by":"crossref","first-page":"15061","DOI":"10.1073\/pnas.0907855106","article-title":"Src family protein tyrosine kinase (PTK) modulates the effect of SGK1 and WNK4 on ROMK channels.","volume":"106","author":"Yue","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R44-14-20230208","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1681\/ASN.2006121333","article-title":"Role of gp91phox -containing NADPH oxidase in mediating the effect of K restriction on ROMK channels and renal K excretion.","volume":"18","author":"Babilonia","year":"2007","journal-title":"J Am Soc Nephrol"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201511000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:26:16Z","timestamp":1786130776000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201511000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2014070658","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]}}}