{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:21:26Z","timestamp":1791354086545,"version":"4.3.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>\n                    Endoplasmic reticulum (ER) stress and disrupted proteostasis contribute to the pathogenesis of a variety of glomerular and tubular diseases. Thus, it is imperative to develop noninvasive biomarkers for detecting ER stress in podocytes or tubular cells in the incipient stage of disease, when a kidney biopsy is not yet clinically indicated. Mesencephalic astrocyte\u2013derived neurotrophic factor (MANF) localizes to the ER lumen and is secreted in response to ER stress in several cell types. Here, using mouse models of human nephrotic syndrome caused by mutant laminin\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    2 protein\u2013induced podocyte ER stress and AKI triggered by tunicamycin\u2013 or ischemia-reperfusion\u2013induced tubular ER stress, we examined MANF as a potential urine biomarker for detecting ER stress in podocytes or renal tubular cells. ER stress upregulated MANF expression in podocytes and tubular cells. Notably, urinary MANF excretion concurrent with podocyte or tubular cell ER stress preceded clinical or histologic manifestations of the corresponding disease. Thus, MANF can potentially serve as a urine diagnostic or prognostic biomarker in ER stress\u2013related kidney diseases to help stratify disease risk, predict disease progression, monitor treatment response, and identify subgroups of patients who can be treated with ER stress modulators in a highly targeted manner.\n                  <\/jats:p>","DOI":"10.1681\/asn.2014100986","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T13:23:40Z","timestamp":1475241820000},"page":"2974-2982","source":"Crossref","is-referenced-by-count":57,"title":["Mesencephalic Astrocyte\u2013Derived Neurotrophic Factor as a Urine Biomarker for Endoplasmic Reticulum Stress\u2013Related Kidney Diseases"],"prefix":"10.1681","volume":"27","author":[{"given":"Yeawon","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal 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