{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:18:33Z","timestamp":1790036313689,"version":"4.0.1"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1681\/asn.2014101009","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T21:41:40Z","timestamp":1431553300000},"page":"227-237","source":"Crossref","is-referenced-by-count":129,"title":["Low Vitamin D and High Fibroblast Growth Factor 23 Serum Levels Associate with Infectious and Cardiac Deaths in the HEMO Study"],"prefix":"10.1681","volume":"27","author":[{"given":"Michel","family":"Chonchol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Greene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"Hoofnagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred K.","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-25-20230208","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1046\/j.1523-1755.2000.00173.x","article-title":"Atherosclerotic cardiovascular disease risks in chronic hemodialysis patients.","volume":"58","author":"Cheung","year":"2000","journal-title":"Kidney Int"},{"key":"R2-25-20230208","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1681\/ASN.2013060632","article-title":"Evidence-based cardiology in hemodialysis patients.","volume":"24","author":"Allon","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"R3-25-20230208","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1097\/01.ASN.0000119144.95922.C4","article-title":"Septicemia in the United States dialysis population, 1991 to 1999.","volume":"15","author":"Foley","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"R4-25-20230208","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/ndt\/gfh729","article-title":"The spectrum of infection-related morbidity in hospitalized haemodialysis patients.","volume":"20","author":"Allon","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"R5-25-20230208","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1681\/ASN.2006040406","article-title":"Infection-related hospitalization rates in pediatric versus adult patients with end-stage renal disease in the United States.","volume":"18","author":"Chavers","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"R6-25-20230208","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.semnephrol.2014.02.007","article-title":"Laboratory abnormalities in CKD-MBD: markers, predictors, or mediators of disease?","volume":"34","author":"Evenepoel","year":"2014","journal-title":"Semin Nephrol"},{"key":"R7-25-20230208","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency.","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med"},{"key":"R8-25-20230208","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/sj.ki.5002451","article-title":"Vitamin D levels and early mortality among incident hemodialysis patients.","volume":"72","author":"Wolf","year":"2007","journal-title":"Kidney Int"},{"key":"R9-25-20230208","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/ndt\/gfq606","article-title":"Vitamin D status and clinical outcomes in incident dialysis patients: results from the NECOSAD study.","volume":"26","author":"Drechsler","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"R10-25-20230208","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1097\/01.ASN.0000133041.27682.A2","article-title":"Mineral metabolism, mortality, and morbidity in maintenance hemodialysis.","volume":"15","author":"Block","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"R11-25-20230208","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.2215\/CJN.00420108","article-title":"Serum phosphate levels and risk of infection in incident dialysis patients.","volume":"3","author":"Plantinga","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"R12-25-20230208","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3109\/07853890.2010.543923","article-title":"Extra-skeletal effects of vitamin D deficiency in chronic kidney disease.","volume":"43","author":"Chonchol","year":"2011","journal-title":"Ann Med"},{"key":"R13-25-20230208","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/18715281113129990046","article-title":"The role of vitamin D in prevention and treatment of infection.","volume":"12","author":"Gunville","year":"2013","journal-title":"Inflamm Allergy Drug Targets"},{"key":"R14-25-20230208","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1126\/science.1123933","article-title":"Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.","volume":"311","author":"Liu","year":"2006","journal-title":"Science"},{"key":"R15-25-20230208","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1074\/jbc.M408903200","article-title":"Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo.","volume":"280","author":"Saito","year":"2005","journal-title":"J Biol Chem"},{"key":"R16-25-20230208","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1525-139X.2007.00308.x","article-title":"Role of fibroblast growth factor 23 in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney disease.","volume":"20","author":"Stubbs","year":"2007","journal-title":"Semin Dial"},{"key":"R17-25-20230208","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1161\/CIRCULATIONAHA.108.844506","article-title":"Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease.","volume":"119","author":"Guti\u00e9rrez","year":"2009","journal-title":"Circulation"},{"key":"R18-25-20230208","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1001\/jama.2011.826","article-title":"Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease.","volume":"305","author":"Isakova","year":"2011","journal-title":"JAMA"},{"key":"R19-25-20230208","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1681\/ASN.2010121224","article-title":"FGF-23 associates with death, cardiovascular events, and initiation of chronic dialysis.","volume":"22","author":"Kendrick","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"R20-25-20230208","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1056\/NEJMoa0706130","article-title":"Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis.","volume":"359","author":"Guti\u00e9rrez","year":"2008","journal-title":"N Engl J Med"},{"key":"R21-25-20230208","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00467-012-2336-0","article-title":"Beyond mineral metabolism, is there an interplay between FGF23 and vitamin D in innate immunity?","volume":"28","author":"Bacchetta","year":"2013","journal-title":"Pediatr Nephrol"},{"key":"R22-25-20230208","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/jbmr.1740","article-title":"Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytes.","volume":"28","author":"Bacchetta","year":"2013","journal-title":"J Bone Miner Res"},{"key":"R23-25-20230208","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1681\/ASN.V13suppl_1s28","article-title":"Inflammation, malnutrition, and cardiac disease as predictors of mortality in hemodialysis patients.","volume":"13","author":"Qureshi","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R24-25-20230208","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1046\/j.1523-1755.2002.00470.x","article-title":"Intercurrent clinical events are predictive of plasma C-reactive protein levels in hemodialysis patients.","volume":"62","author":"van Tellingen","year":"2002","journal-title":"Kidney Int"},{"key":"R25-25-20230208","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1056\/NEJMoa021583","article-title":"Effect of dialysis dose and membrane flux in maintenance hemodialysis.","volume":"347","author":"Eknoyan","year":"2002","journal-title":"N Engl J Med"},{"key":"R26-25-20230208","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/sj.ki.5002009","article-title":"Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease.","volume":"71","author":"Levin","year":"2007","journal-title":"Kidney Int"},{"key":"R27-25-20230208","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/sj.ki.5002002","article-title":"25-Hydroxyvitamin D, insulin resistance, and kidney function in the Third National Health and Nutrition Examination Survey.","volume":"71","author":"Chonchol","year":"2007","journal-title":"Kidney Int"},{"key":"R29-25-20230208","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/sj.ki.5000394","article-title":"25-Hydroxyvitamin D(3) suppresses PTH synthesis and secretion by bovine parathyroid cells.","volume":"70","author":"Ritter","year":"2006","journal-title":"Kidney Int"},{"key":"R30-25-20230208","doi-asserted-by":"crossref","first-page":"1678S","DOI":"10.1093\/ajcn\/80.6.1678S","article-title":"Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.","volume":"80","author":"Holick","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"R31-25-20230208","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1126\/science.505004","article-title":"Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid.","volume":"206","author":"Stumpf","year":"1979","journal-title":"Science"},{"key":"R32-25-20230208","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.1111\/j.1753-4887.2008.00096.x","article-title":"Regulation of vitamin D homeostasis: implications for the immune system.","volume":"66","author":"van Etten","year":"2008","journal-title":"Nutr Rev"},{"key":"R33-25-20230208","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1479-5876-7-28","article-title":"Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis.","volume":"7","author":"Jeng","year":"2009","journal-title":"J Transl Med"},{"key":"R34-25-20230208","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1001\/archinternmed.2008.560","article-title":"Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey.","volume":"169","author":"Ginde","year":"2009","journal-title":"Arch Intern Med"},{"key":"R35-25-20230208","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/ajcn\/86.3.714","article-title":"An association of serum vitamin D concentrations < 40 nmol\/L with acute respiratory tract infection in young Finnish men.","volume":"86","author":"Laaksi","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"R36-25-20230208","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/ajcn\/79.3.362","article-title":"Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis.","volume":"79","author":"Holick","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"R37-25-20230208","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1681\/ASN.2006060573","article-title":"Mineral metabolism and arterial functions in end-stage renal disease: potential role of 25-hydroxyvitamin D deficiency.","volume":"18","author":"London","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"R38-25-20230208","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/MAJ.0b013e3181815498","article-title":"Fibroblast growth factor 23: a possible cause of left ventricular hypertrophy in hemodialysis patients.","volume":"337","author":"Hsu","year":"2009","journal-title":"Am J Med Sci"},{"key":"R39-25-20230208","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy.","volume":"121","author":"Faul","year":"2011","journal-title":"J Clin Invest"},{"key":"R40-25-20230208","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/clinchem\/27.5.773","article-title":"Stability of vitamin D metabolites in human blood serum and plasma.","volume":"27","author":"Lissner","year":"1981","journal-title":"Clin Chem"},{"key":"R41-25-20230208","doi-asserted-by":"crossref","first-page":"511S","DOI":"10.1093\/ajcn\/88.2.511S","article-title":"Development of a standard reference material for vitamin D in serum.","volume":"88","author":"Phinney","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"R42-25-20230208","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1210\/jc.2005-2105","article-title":"Sensitivity of fibroblast growth factor 23 measurements in tumor-induced osteomalacia.","volume":"91","author":"Imel","year":"2006","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201601000-00025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:26:29Z","timestamp":1786130789000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201601000-00025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2014101009","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}