{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:48:37Z","timestamp":1791276517373,"version":"4.1.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>\n                    The earliest symptom of glomerular injury in patients with sickle cell disease (SCD) is microalbuminuria. The effect of hydroxyurea (HU) on urine albumin-to-creatinine ratio (ACR) is unclear and should be determined, because increasing numbers of patients with SCD take this drug to improve red blood cell function. In this cohort study of 58 SS-homozygous adults with SCD who initiated HU therapy, we evaluated ACR changes and relationships of these changes with demographic, clinical, and biologic parameters at HU initiation (baseline) and 6 months later (follow-up). Between baseline and follow-up, ACR declined significantly for the entire population (3.0\u20131.7 mg\/mmol;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.01), but this was primarily driven by the ACR reduction in the microalbuminuria subgroup (8.1\u20132.3 mg\/mmol;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.03;\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =23). According to bivariate analyses on 39 patients who did not receive a blood transfusion during the study period, the baseline to follow-up ACR decline was strongly associated with decreases in levels of hemolysis markers, percentage of dense red blood cells, and systolic BP. Bivariate analysis also revealed a close association between the ACR decrease and high baseline levels of hemolysis markers and percentage of dense red blood cells. These results show that urine ACR decreased significantly after 6 months of HU and confirm a close relationship between ACR and hemolysis evolution in patients with SCD.\n                  <\/jats:p>","DOI":"10.1681\/asn.2014111126","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T17:13:18Z","timestamp":1452532398000},"page":"1847-1853","source":"Crossref","is-referenced-by-count":89,"title":["Six Months of Hydroxyurea Reduces Albuminuria in Patients with Sickle Cell Disease"],"prefix":"10.1681","volume":"27","author":[{"given":"Pablo","family":"Bartolucci","sequence":"first","affiliation":[{"name":"Sickle Cell Referral Center,"},{"name":"Department of Internal Medicine,"},{"name":"Groupe Hospitalier Henri Mondor-Albert Chenevier, Assistance Publique\u2013H\u00f4pitaux de Paris, Universit\u00e9 Paris-Est Cr\u00e9teil, Creteil, France;"},{"name":"Unit\u00e9 Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM) U955, Equipe 2 and"},{"name":"Laboratory of Excellence Globule Rouge Excellence (GR-Ex), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoosha","family":"Habibi","sequence":"additional","affiliation":[{"name":"Sickle Cell Referral Center,"},{"name":"Department of Internal Medicine,"},{"name":"Groupe Hospitalier Henri Mondor-Albert Chenevier, Assistance Publique\u2013H\u00f4pitaux de Paris, Universit\u00e9 Paris-Est Cr\u00e9teil, Creteil, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Stehl\u00e9","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation,"},{"name":"Groupe Hospitalier Henri Mondor-Albert Chenevier, Assistance Publique\u2013H\u00f4pitaux de Paris, Universit\u00e9 Paris-Est Cr\u00e9teil, Creteil, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetana","family":"Di Liberto","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier Henri Mondor-Albert Chenevier, Assistance Publique\u2013H\u00f4pitaux de Paris, Universit\u00e9 Paris-Est Cr\u00e9teil, Creteil, France;"},{"name":"Unit\u00e9 Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM) U955, Equipe 2 and"},{"name":"Laboratory of Excellence Globule Rouge Excellence (GR-Ex), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Georgine","family":"Rakotoson","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier Henri Mondor-Albert Chenevier, Assistance Publique\u2013H\u00f4pitaux de Paris, Universit\u00e9 Paris-Est Cr\u00e9teil, Creteil, France;"},{"name":"Unit\u00e9 Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale (INSERM) U955, Equipe 2 and"},{"name":"Laboratory of Excellence Globule Rouge Excellence (GR-Ex), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Gellen-Dautremer","sequence":"additional","affiliation":[{"name":"Sickle Cell Referral Center,"},{"name":"Department of Internal Medicine,"},{"name":"Groupe Hospitalier Henri Mondor-Albert Chenevier, Assistance Publique\u2013H\u00f4pitaux de Paris, Universit\u00e9 Paris-Est Cr\u00e9teil, Creteil, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Loric","sequence":"additional","affiliation":[{"name":"Departement de Biochimie\u2013Pharmacotoxicologie,"},{"name":"Groupe Hospitalier Henri Mondor-Albert Chenevier, Assistance Publique\u2013H\u00f4pitaux de Paris, Universit\u00e9 Paris-Est Cr\u00e9teil, Creteil, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Moutereau","sequence":"additional","affiliation":[{"name":"Departement de Biochimie\u2013Pharmacotoxicologie,"},{"name":"Groupe Hospitalier Henri Mondor-Albert Chenevier, Assistance Publique\u2013H\u00f4pitaux de Paris, Universit\u00e9 Paris-Est Cr\u00e9teil, Creteil, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dil","family":"Sahali","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation,"},{"name":"Groupe Hospitalier Henri Mondor-Albert Chenevier, Assistance Publique\u2013H\u00f4pitaux de Paris, Universit\u00e9 Paris-Est Cr\u00e9teil, Creteil, France;"},{"name":"Unit\u00e9 INSERM U955, Equipe 21, Idiopathic Nephrotic Syndrome Referral Center, Universit\u00e9 Paris-Est Cr\u00e9teil, Creteil, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orianne","family":"Wagner-Ballon","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunology Biology, and"},{"name":"Groupe Hospitalier Henri Mondor-Albert Chenevier, Assistance Publique\u2013H\u00f4pitaux de Paris, Universit\u00e9 Paris-Est Cr\u00e9teil, Creteil, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Remy","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation,"},{"name":"Groupe Hospitalier Henri Mondor-Albert Chenevier, Assistance Publique\u2013H\u00f4pitaux de Paris, Universit\u00e9 Paris-Est Cr\u00e9teil, Creteil, France;"},{"name":"Unit\u00e9 INSERM U955, Equipe 21, Idiopathic Nephrotic Syndrome Referral Center, Universit\u00e9 Paris-Est Cr\u00e9teil, Creteil, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation,"},{"name":"Groupe Hospitalier Henri Mondor-Albert Chenevier, Assistance Publique\u2013H\u00f4pitaux de Paris, Universit\u00e9 Paris-Est Cr\u00e9teil, Creteil, France;"},{"name":"Unit\u00e9 INSERM U955, Equipe 21, Idiopathic Nephrotic Syndrome Referral Center, Universit\u00e9 Paris-Est Cr\u00e9teil, Creteil, France; 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