{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:03:26Z","timestamp":1786133006484,"version":"build-2736575974"},"reference-count":66,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>\n                    Store-operated calcium entry (SOCE) is the mechanism by which extracellular signals elicit prolonged intracellular calcium elevation to drive changes in fundamental cellular processes. Here, we investigated the role of SOCE in the regulation of renal water reabsorption, using the inbred rat strain SHR-A3 as an animal model with disrupted SOCE. We found that SHR-A3, but not SHR-B2, have a novel truncating mutation in the gene encoding stromal interaction molecule 1 (STIM1), the endoplasmic reticulum calcium (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) sensor that triggers SOCE. Balance studies revealed increased urine volume, hypertonic plasma, polydipsia, and impaired urinary concentrating ability accompanied by elevated circulating arginine vasopressin (AVP) levels in SHR-A3 compared with SHR-B2. Isolated, split-open collecting ducts (CD) from SHR-A3 displayed decreased basal intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    levels and a major defect in SOCE. Consequently, AVP failed to induce the sustained intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    mobilization that requires SOCE in CD cells from SHR-A3. This effect decreased the abundance of aquaporin 2 and enhanced its intracellular retention, suggesting impaired sensitivity of the CD to AVP in SHR-A3.\n                    <jats:italic toggle=\"yes\">Stim1<\/jats:italic>\n                    knockdown in cultured mpkCCD\n                    <jats:sub>c14<\/jats:sub>\n                    cells reduced SOCE and basal intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    levels and prevented AVP-induced translocation of aquaporin 2, further suggesting the effects in SHR-A3 result from the expression of truncated STIM1. Overall, these results identify a novel mechanism of nephrogenic diabetes insipidus and uncover a role of SOCE in renal water handling.\n                  <\/jats:p>","DOI":"10.1681\/asn.2014121200","type":"journal-article","created":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T22:19:10Z","timestamp":1447712350000},"page":"2035-2048","source":"Crossref","is-referenced-by-count":32,"title":["Defective Store-Operated Calcium Entry Causes Partial Nephrogenic Diabetes Insipidus"],"prefix":"10.1681","volume":"27","author":[{"given":"Mykola","family":"Mamenko","sequence":"first","affiliation":[{"name":"Department of Integrative Biology and Pharmacology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isha","family":"Dhande","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Tomilin","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology and Pharmacology, and"},{"name":"Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Zaika","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology and Pharmacology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila","family":"Boukelmoune","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology and Pharmacology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas; 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