{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:10:10Z","timestamp":1791857410194,"version":"4.3.4"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>\n                    Several studies suggest a link between post-transplant hypomagnesemia and new-onset diabetes after transplantation (NODAT), but this relationship remains controversial. We conducted a retrospective cohort study of 948 nondiabetic kidney transplant recipients from January 1, 2000, to December 31, 2011, to examine the association between serum magnesium level and NODAT. Multivariable Cox proportional hazards models were fitted to evaluate the risk of NODAT as a function of baseline (at 1 month), time-varying (every 3 months), and rolling-average (\n                    <jats:italic toggle=\"yes\">i.e.<\/jats:italic>\n                    , mean for 3 months moving at 3-month intervals) serum magnesium levels while adjusting for potential confounders. A total of 182 NODAT events were observed over 2951.2 person-years of follow-up. Multivariable models showed an inverse relationship between baseline serum magnesium level and NODAT (hazard ratio [HR], 1.24 per 0.1 mmol\/L decrease; 95% confidence interval [95% CI], 1.05 to 1.46;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.01). The association with the risk of NODAT persisted in conventional time-varying (HR, 1.32; 95% CI, 1.14 to 1.52;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.001) and rolling-average models (HR, 1.34; 95% CI, 1.13 to 1.57;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.001). Hypomagnesemia (serum magnesium &lt;0.74 mmol\/L) also significantly associated with increased risk of NODAT in baseline (HR, 1.58; 95% CI, 1.07 to 2.34;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.02), time-varying (HR, 1.78; 95% CI, 1.29 to 2.45;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.001), and rolling-average models (HR, 1.83; 95% CI, 1.30 to 2.57;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.001). Our results suggest that lower post-transplant serum magnesium level is an independent risk factor for NODAT in kidney transplant recipients. Interventions targeting serum magnesium to reduce the risk of NODAT should be evaluated.\n                  <\/jats:p>","DOI":"10.1681\/asn.2015040391","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T23:03:55Z","timestamp":1444345435000},"page":"1793-1800","source":"Crossref","is-referenced-by-count":69,"title":["Hypomagnesemia and the Risk of New-Onset Diabetes Mellitus after Kidney Transplantation"],"prefix":"10.1681","volume":"27","author":[{"given":"Johnny W.","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Nephrology and the Kidney Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olusegun","family":"Famure","sequence":"additional","affiliation":[{"name":"Division of Nephrology and the Kidney Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Nephrology and the Kidney Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Joseph","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Nephrology and the Kidney Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada;"},{"name":"Division of Nephrology and the Renal Transplant Program, St. Michael\u2019s Hospital, University of Toronto, Toronto, Ontario, Canada; and"},{"name":"Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,10,8]]},"reference":[{"key":"B1-20230819","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1432-2277.2008.00800.x","article-title":"New-onset diabetes mellitus after solid organ transplantation.","volume":"22","author":"Bodziak","year":"2009","journal-title":"Transpl Int"},{"key":"B2-20230819","doi-asserted-by":"crossref","first-page":"805","DOI":"10.2337\/diacare.27.3.805","article-title":"New-Onset Diabetes After Transplantation 2003 International Consensus Guidelines: an endocrinologist\u2019s view.","volume":"27","author":"Davidson","year":"2004","journal-title":"Diabetes Care"},{"key":"B3-20230819","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.transproceed.2011.04.008","article-title":"New-onset diabetes after renal transplantation: diagnosis, incidence, risk factors, impact on outcomes, and novel implications.","volume":"43","author":"Kaposztas","year":"2011","journal-title":"Transplant Proc"},{"key":"B4-20230819","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1034\/j.1600-6143.2003.00010.x","article-title":"Diabetes mellitus after kidney transplantation in the United States.","volume":"3","author":"Kasiske","year":"2003","journal-title":"Am J Transplant"},{"key":"B5-20230819","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1111\/j.1523-1755.2002.kid582.x","article-title":"Patient survival after renal transplantation: IV. 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