{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:32:29Z","timestamp":1792715549668,"version":"4.5.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2016,8]]},"abstract":"\n Tertiary hyperparathyroidism is a common cause of hypercalcemia after kidney transplant. We designed this 12-month, prospective, multicenter, open\u2013label, randomized study to evaluate whether subtotal parathyroidectomy is more effective than cinacalcet for controlling hypercalcemia caused by persistent hyperparathyroidism after kidney transplant. Kidney allograft recipients with hypercalcemia and elevated intact parathyroid hormone (iPTH) concentration were eligible if they had received a transplant \u22656 months before the study and had an eGFR>30 ml\/min per 1.73 m\n 2<\/jats:sup>\n . The primary end point was the proportion of patients with normocalcemia at 12 months. Secondary end points were serum iPTH concentration, serum phosphate concentration, bone mineral density, vascular calcification, renal function, patient and graft survival, and economic cost. In total, 30 patients were randomized to receive cinacalcet (\n n<\/jats:italic>\n =15) or subtotal parathyroidectomy (\n n<\/jats:italic>\n =15). At 12 months, ten of 15 patients in the cinacalcet group and 15 of 15 patients in the parathyroidectomy group (\n P<\/jats:italic>\n =0.04) achieved normocalcemia. Normalization of serum phosphate concentration occurred in almost all patients. Subtotal parathyroidectomy induced greater reduction of iPTH and associated with a significant increase in femoral neck bone mineral density; vascular calcification remained unchanged in both groups. The most frequent adverse events were digestive intolerance in the cinacalcet group and hypocalcemia in the parathyroidectomy group. Surgery would be more cost effective than cinacalcet if cinacalcet duration reached 14 months. All patients were alive with a functioning graft at the end of follow-up. In conclusion, subtotal parathyroidectomy was superior to cinacalcet in controlling hypercalcemia in these patients with kidney transplants and persistent hyperparathyroidism.\n <\/jats:p>","DOI":"10.1681\/asn.2015060622","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T09:07:03Z","timestamp":1449652023000},"page":"2487-2494","source":"Crossref","is-referenced-by-count":151,"title":["A Randomized Study Comparing Parathyroidectomy with Cinacalcet for Treating Hypercalcemia in Kidney Allograft Recipients with Hyperparathyroidism"],"prefix":"10.1681","volume":"27","author":[{"given":"Josep M.","family":"Cruzado","sequence":"first","affiliation":[{"name":"Nephrology Department, Hospital Universitari de Bellvitge, University of Barcelona, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L\u2019Hospitalet de Llobregat, Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Moreno","sequence":"additional","affiliation":[{"name":"Departments of Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 V.","family":"Torregrosa","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplant Service, Hospital Cl\u00ednic, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Taco","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Universitari de Bellvitge, University of Barcelona, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L\u2019Hospitalet de Llobregat, Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Mast","sequence":"additional","affiliation":[{"name":"Radiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"G\u00f3mez-Vaquero","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital Universitari de Bellvitge, L\u2019Hospitalet de Llobregat, Barcelona, Spain; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Polo","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Universitari de Bellvitge, University of Barcelona, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L\u2019Hospitalet de Llobregat, Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Revuelta","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplant Service, Hospital Cl\u00ednic, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Francos","sequence":"additional","affiliation":[{"name":"Departments of Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Torras","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Universitari de Bellvitge, University of Barcelona, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L\u2019Hospitalet de Llobregat, Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arantxa","family":"Garc\u00eda-Barrasa","sequence":"additional","affiliation":[{"name":"Departments of Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Bestard","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Universitari de Bellvitge, University of Barcelona, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L\u2019Hospitalet de Llobregat, Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep M.","family":"Griny\u00f3","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Universitari de Bellvitge, University of Barcelona, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L\u2019Hospitalet de Llobregat, Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2015,12,8]]},"reference":[{"key":"B1-20230819","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1056\/NEJM199912023412303","article-title":"Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant.","volume":"341","author":"Wolfe","year":"1999","journal-title":"N Engl J Med"},{"key":"B2-20230819","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1056\/NEJMp048256","article-title":"Transplantation--a medical miracle of the 20th century.","volume":"351","author":"Morris","year":"2004","journal-title":"N 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