{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T10:23:50Z","timestamp":1793701430785,"version":"4.5.1"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2017,1]]},"abstract":"\n Podocyte injury is the inciting event in primary glomerulopathies, such as minimal change disease and primary FSGS, and glucocorticoids remain the initial and often, the primary treatment of choice for these glomerulopathies. Because inflammation is not readily apparent in these diseases, understanding the direct effects of glucocorticoids on the podocyte, independent of the immunomodulatory effects, may lead to the identification of targets downstream of glucocorticoids that minimize toxicity without compromising efficacy. Several studies showed that treatment with glucocorticoids restores podocyte differentiation markers and normal ultrastructure and improves cell survival in murine podocytes. We previously determined that Kr\u00fcppel\u2013like factor 15 (KLF15), a kidney\u2013enriched zinc finger transcription factor, is required for restoring podocyte differentiation markers in mice and human podocytes under cell stress. Here, we show that\n in vitro<\/jats:italic>\n treatment with dexamethasone induced a rapid increase of KLF15 expression in human and murine podocytes and enhanced the affinity of glucocorticoid receptor binding to the promoter region of\n KLF15<\/jats:italic>\n . In three independent proteinuric murine models, podocyte-specific loss of\n Klf15<\/jats:italic>\n abrogated dexamethasone\u2013induced podocyte recovery. Furthermore, knockdown of\n KLF15<\/jats:italic>\n reduced cell survival and destabilized the actin cytoskeleton in differentiated human podocytes. Conversely, overexpression of\n KLF15<\/jats:italic>\n stabilized the actin cytoskeleton under cell stress in human podocytes. Finally, the level of KLF15 expression in the podocytes and glomeruli from human biopsy specimens correlated with glucocorticoid responsiveness in 35 patients with minimal change disease or primary FSGS. Thus, these studies identify the critical role of KLF15 in mediating the salutary effects of glucocorticoids in the podocyte.\n <\/jats:p>","DOI":"10.1681\/asn.2015060672","type":"journal-article","created":{"date-parts":[[2016,6,11]],"date-time":"2016-06-11T00:37:05Z","timestamp":1465605425000},"page":"166-184","source":"Crossref","is-referenced-by-count":68,"title":["Kr\u00fcppel\u2013Like Factor 15 Mediates Glucocorticoid-Induced Restoration of Podocyte Differentiation Markers"],"prefix":"10.1681","volume":"28","author":[{"given":"Sandeep K.","family":"Mallipattu","sequence":"first","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Guo","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica P.","family":"Revelo","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Roa-Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Miller","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Ling","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart J.","family":"Shankland","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka B.","family":"Bialkowska","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Stony Brook University, Stony Brook, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Ly","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Estrada","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh K.","family":"Jain","sequence":"additional","affiliation":[{"name":"Case Cardiovascular Institute Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Case Cardiovascular Institute Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avi","family":"Ma\u2019ayan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Systems Therapeutics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabi","family":"Yacoub","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward P.","family":"Nord","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Woroniecki","sequence":"additional","affiliation":[{"name":"Pediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent W.","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Stony Brook University, Stony Brook, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Systems Therapeutics and"},{"name":"Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; and"},{"name":"Renal Section, James J. Peters Veterans Affairs Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,6,10]]},"reference":[{"key":"B1-20230819","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/sj.ki.5002222","article-title":"The spectrum of podocytopathies: A unifying view of glomerular diseases.","volume":"71","author":"Wiggins","year":"2007","journal-title":"Kidney Int"},{"key":"B2-20230819","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/ncpneph0025","article-title":"Mechanisms of disease: Focal segmental glomerulosclerosis.","volume":"1","author":"Meyrier","year":"2005","journal-title":"Nat Clin Pract Nephrol"},{"key":"B3-20230819","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1053\/j.ackd.2012.02.018","article-title":"Podocyte biology in segmental sclerosis and progressive glomerular injury.","volume":"19","author":"Barisoni","year":"2012","journal-title":"Adv Chronic Kidney Dis"},{"key":"B4-20230819","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1042\/cs0940557","article-title":"Anti-inflammatory actions of glucocorticoids: Molecular mechanisms.","volume":"94","author":"Barnes","year":"1998","journal-title":"Clin Sci (Lond)"},{"key":"B5-20230819","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1006\/phrs.2002.0969","article-title":"Molecular mechanisms of immunomodulatory activity of glucocorticoids.","volume":"45","author":"Riccardi","year":"2002","journal-title":"Pharmacol Res"},{"key":"B6-20230819","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00467-010-1717-5","article-title":"New therapies in steroid-sensitive and steroid-resistant idiopathic nephrotic syndrome.","volume":"26","author":"van Husen","year":"2011","journal-title":"Pediatr Nephrol"},{"key":"B7-20230819","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/ndt\/gfq617","article-title":"The podocyte as a direct target of immunosuppressive agents.","volume":"26","author":"Sch\u00f6nenberger","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"B8-20230819","doi-asserted-by":"crossref","first-page":"F845","DOI":"10.1152\/ajprenal.00161.2010","article-title":"Dose- and time-dependent glucocorticoid receptor signaling in podocytes.","volume":"299","author":"Guess","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"B9-20230819","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1681\/ASN.2005020142","article-title":"Dexamethasone prevents podocyte apoptosis induced by puromycin aminonucleoside: Role of p53 and Bcl-2-related family proteins.","volume":"16","author":"Wada","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"B10-20230819","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1159\/000131892","article-title":"Dexamethasone\u2019s prosurvival benefits in podocytes require extracellular signal-regulated kinase phosphorylation.","volume":"109","author":"Wada","year":"2008","journal-title":"Nephron, Exp Nephrol"},{"key":"B11-20230819","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/sj.ki.5001655","article-title":"Direct effects of dexamethasone on human podocytes.","volume":"70","author":"Xing","year":"2006","journal-title":"Kidney Int"},{"key":"B12-20230819","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/j.1523-1755.2005.00205.x","article-title":"Differential proteomic analysis of proteins induced by glucocorticoids in cultured murine podocytes.","volume":"67","author":"Ransom","year":"2005","journal-title":"Kidney Int"},{"key":"B13-20230819","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.1073\/pnas.0511257103","article-title":"Comparative promoter analysis allows de novo identification of specialized cell junction-associated proteins.","volume":"103","author":"Cohen","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B14-20230819","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1152\/physrev.00058.2009","article-title":"Mammalian Kr\u00fcppel-like factors in health and diseases.","volume":"90","author":"McConnell","year":"2010","journal-title":"Physiol Rev"},{"key":"B15-20230819","doi-asserted-by":"crossref","first-page":"19122","DOI":"10.1074\/jbc.M112.345983","article-title":"Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation.","volume":"287","author":"Mallipattu","year":"2012","journal-title":"J Biol Chem"},{"key":"B16-20230819","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/labinvest.2010.170","article-title":"DNA binding-dependent glucocorticoid receptor activity promotes adipogenesis via Kr\u00fcppel-like factor 15 gene expression.","volume":"91","author":"Asada","year":"2011","journal-title":"Lab Invest"},{"key":"B17-20230819","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1165\/rcmb.2010-0369OC","article-title":"Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsiveness.","volume":"45","author":"Masuno","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B18-20230819","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/nar\/gkg108","article-title":"TRANSFAC: Transcriptional regulation, from patterns to profiles.","volume":"31","author":"Matys","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"B19-20230819","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: Interactive and collaborative HTML5 gene list enrichment analysis tool.","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"B20-20230819","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1172\/JCI20402","article-title":"Induction of B7-1 in podocytes is associated with nephrotic syndrome.","volume":"113","author":"Reiser","year":"2004","journal-title":"J Clin Invest"},{"key":"B21-20230819","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1159\/000191469","article-title":"Glomerular transcriptome changes associated with lipopolysaccharide-induced proteinuria.","volume":"29","author":"Sun","year":"2009","journal-title":"Am J Nephrol"},{"key":"B22-20230819","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nm.2261","article-title":"Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome.","volume":"17","author":"Clement","year":"2011","journal-title":"Nat Med"},{"key":"B23-20230819","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0002-9440(10)64729-3","article-title":"Lipopolysaccharide pretreatment protects from renal ischemia\/reperfusion injury : Possible connection to an interleukin-6-dependent pathway.","volume":"156","author":"Heemann","year":"2000","journal-title":"Am J Pathol"},{"key":"B24-20230819","doi-asserted-by":"crossref","first-page":"632","DOI":"10.4049\/jimmunol.176.1.632","article-title":"Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1\/TNF-alpha production.","volume":"176","author":"Fu","year":"2006","journal-title":"J Immunol"},{"key":"B25-20230819","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1097\/01.ASN.0000136312.46464.33","article-title":"Danger signaling by glomerular podocytes defines a novel function of inducible B7-1 in the pathogenesis of nephrotic syndrome.","volume":"15","author":"Reiser","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"B26-20230819","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s12079-012-0184-0","article-title":"LPS and PAN-induced podocyte injury in an in vitro model of minimal change disease: Changes in TLR profile.","volume":"7","author":"Srivastava","year":"2013","journal-title":"J Cell Commun Signal"},{"key":"B27-20230819","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1172\/JCI69557","article-title":"KLF4-dependent epigenetic remodeling modulates podocyte phenotypes and attenuates proteinuria.","volume":"124","author":"Hayashi","year":"2014","journal-title":"J Clin Invest"},{"key":"B28-20230819","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/ki.2015.178","article-title":"Renin-angiotensin blockade resets podocyte epigenome through Kruppel-like Factor 4 and attenuates proteinuria.","volume":"88","author":"Hayashi","year":"2015","journal-title":"Kidney Int"},{"key":"B29-20230819","doi-asserted-by":"crossref","first-page":"F213","DOI":"10.1152\/ajprenal.90421.2008","article-title":"Inducible rodent models of acquired podocyte diseases.","volume":"296","author":"Pippin","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"B30-20230819","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ki.2010.81","article-title":"Regression of glomerulosclerosis in response to transient treatment with angiotensin II blockers is attenuated by blockade of matrix metalloproteinase-2.","volume":"78","author":"Hayashi","year":"2010","journal-title":"Kidney Int"},{"key":"B31-20230819","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1440-1797.2010.01383.x","article-title":"Adriamycin nephropathy: A model of focal segmental glomerulosclerosis.","volume":"16","author":"Lee","year":"2011","journal-title":"Nephrology (Carlton)"},{"key":"B32-20230819","doi-asserted-by":"crossref","first-page":"F1375","DOI":"10.1152\/ajprenal.00020.2013","article-title":"Podocyte repopulation by renal progenitor cells following glucocorticoids treatment in experimental FSGS.","volume":"304","author":"Zhang","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"B33-20230819","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1242\/dev.042887","article-title":"Notch signaling, wt1 and foxc2 are key regulators of the podocyte gene regulatory network in Xenopus.","volume":"137","author":"White","year":"2010","journal-title":"Development"},{"key":"B34-20230819","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1128\/MCB.01474-12","article-title":"The glucocorticoid receptor and KLF15 regulate gene expression dynamics and integrate signals through feed-forward circuitry.","volume":"33","author":"Sasse","year":"2013","journal-title":"Mol Cell Biol"},{"key":"B35-20230819","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nature07526","article-title":"The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm.","volume":"457","author":"Weavers","year":"2009","journal-title":"Nature"},{"key":"B36-20230819","doi-asserted-by":"crossref","first-page":"e0134620","DOI":"10.1371\/journal.pone.0134620","article-title":"Klf15 is critical for the development and differentiation of drosophila nephrocytes.","volume":"10","author":"Ivy","year":"2015","journal-title":"PLoS One"},{"key":"B37-20230819","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1172\/JCI68552","article-title":"Kruppel-like factor 15 is critical for vascular inflammation.","volume":"123","author":"Lu","year":"2013","journal-title":"J Clin Invest"},{"key":"B38-20230819","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.7326\/0003-4819-119-12-199312150-00007","article-title":"Glucocorticoid therapy for immune-mediated diseases: Basic and clinical correlates.","volume":"119","author":"Boumpas","year":"1993","journal-title":"Ann Intern Med"},{"key":"B39-20230819","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0002-9343(94)90131-7","article-title":"Low dose long-term corticosteroid therapy in rheumatoid arthritis: An analysis of serious adverse events.","volume":"96","author":"Saag","year":"1994","journal-title":"Am J Med"},{"key":"B40-20230819","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1136\/ard.2005.038638","article-title":"Safety of low dose glucocorticoid treatment in rheumatoid arthritis: Published evidence and prospective trial data.","volume":"65","author":"Da Silva","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"B41-20230819","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1158\/1535-7163.MCT-08-0767","article-title":"Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening.","volume":"8","author":"Bialkowska","year":"2009","journal-title":"Mol Cancer Ther"},{"key":"B42-20230819","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1681\/ASN.2006070727","article-title":"Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway.","volume":"18","author":"He","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"B43-20230819","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/ki.2012.445","article-title":"Expression of HIV transgene aggravates kidney injury in diabetic mice.","volume":"83","author":"Mallipattu","year":"2013","journal-title":"Kidney Int"},{"key":"B44-20230819","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1172\/JCI77084","article-title":"Kr\u00fcppel-like factor 6 regulates mitochondrial function in the kidney.","volume":"125","author":"Mallipattu","year":"2015","journal-title":"J Clin Invest"},{"key":"B45-20230819","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2215\/CJN.03531006","article-title":"Adult minimal-change disease: Clinical characteristics, treatment, and outcomes.","volume":"2","author":"Waldman","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"B46-20230819","doi-asserted-by":"crossref","first-page":"F702","DOI":"10.1152\/ajprenal.00428.2009","article-title":"De novo expression of podocyte proteins in parietal epithelial cells during experimental glomerular disease.","volume":"298","author":"Ohse","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"B47-20230819","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0002-9440(10)64239-3","article-title":"A new method for large scale isolation of kidney glomeruli from mice.","volume":"161","author":"Takemoto","year":"2002","journal-title":"Am J Pathol"},{"key":"B48-20230819","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1038\/sj.ki.5000398","article-title":"An improved method for primary culture of rat podocytes.","volume":"69","author":"Katsuya","year":"2006","journal-title":"Kidney Int"},{"key":"B49-20230819","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ki.2013.197","article-title":"Podocyte-specific deletion of signal transducer and activator of transcription 3 attenuates nephrotoxic serum-induced glomerulonephritis.","volume":"84","author":"Dai","year":"2013","journal-title":"Kidney Int"},{"key":"B50-20230819","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1172\/JCI69778","article-title":"Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance.","volume":"124","author":"Tian","year":"2014","journal-title":"J Clin Invest"},{"key":"B51-20230819","doi-asserted-by":"crossref","first-page":"F1008","DOI":"10.1152\/ajprenal.00597.2013","article-title":"Diabetic nephropathy in a nonobese mouse model of type 2 diabetes mellitus.","volume":"306","author":"Mallipattu","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"key":"B52-20230819","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/ki.2011.467","article-title":"Roflumilast enhances the renal protective effects of retinoids in an HIV-1 transgenic mouse model of rapidly progressive renal failure.","volume":"81","author":"Zhong","year":"2012","journal-title":"Kidney Int"},{"key":"B53-20230819","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1681\/ASN.2012111078","article-title":"Estimation of glomerular podocyte number: A selection of valid methods.","volume":"24","author":"Lemley","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"B54-20230819","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1038\/ki.1994.189","article-title":"Long-term renal tolerance of cyclosporin A treatment in adult idiopathic nephrotic syndrome.","volume":"45","author":"Meyrier","year":"1994","journal-title":"Kidney Int"},{"key":"B55-20230819","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0022-3476(05)82020-7","article-title":"Treatment of childhood steroid-resistant idiopathic nephrosis with a combination of cyclosporine and prednisone.","volume":"125","author":"Niaudet","year":"1994","journal-title":"J Pediatr"},{"key":"B56-20230819","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1681\/ASN.V7156","article-title":"A randomized double-blind placebo-controlled trial of cyclosporine in steroid-resistant idiopathic focal segmental glomerulosclerosis in children.","volume":"7","author":"Lieberman","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"B57-20230819","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/ki.1993.194","article-title":"A randomized trial of cyclosporine in steroid-resistant idiopathic nephrotic syndrome.","volume":"43","author":"Ponticelli","year":"1993","journal-title":"Kidney Int"},{"issue":"Suppl 4th Report","key":"B58-20230819","first-page":"555","article-title":"The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents.","volume":"114","year":"2004","journal-title":"Pediatrics"},{"key":"B59-20230819","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8).","volume":"311","author":"James","year":"2014","journal-title":"JAMA"},{"key":"B60-20230819","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate.","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"B61-20230819","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1681\/ASN.2008030287","article-title":"New equations to estimate GFR in children with CKD.","volume":"20","author":"Schwartz","year":"2009","journal-title":"J Am Soc Nephrol"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201701000-00021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:27:58Z","timestamp":1786130878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201701000-00021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,10]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2015060672","relation":{},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,10]]}}}