{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:03:50Z","timestamp":1786133030165,"version":"build-2736575974"},"reference-count":81,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>Nephrogenic diabetes insipidus (NDI) is caused by impairment of vasopressin (VP) receptor type 2 signaling. Because potential therapies for NDI that target the canonical VP\/cAMP\/protein kinase A pathway have so far proven ineffective, alternative strategies for modulating aquaporin 2 (AQP2) trafficking have been sought. Successful identification of compounds by our high\u2013throughput chemical screening assay prompted us to determine whether EGF receptor (EGFR) inhibitors stimulate AQP2 trafficking and reduce urine output. Erlotinib, a selective EGFR inhibitor, enhanced AQP2 apical membrane expression in collecting duct principal cells and reduced urine volume by 45% after 5 days of treatment in mice with lithium-induced NDI. Similar to VP, erlotinib increased exocytosis and decreased endocytosis in LLC-PK1 cells, resulting in a significant increase in AQP2 membrane accumulation. Erlotinib increased phosphorylation of AQP2 at Ser-256 and Ser-269 and decreased phosphorylation at Ser-261 in a dose-dependent manner. However, unlike VP, the effect of erlotinib was independent of cAMP, cGMP, and protein kinase A. Conversely, EGF reduced VP\u2013induced AQP2 Ser-256 phosphorylation, suggesting crosstalk between VP and EGF in AQP2 trafficking and a role of EGF in water homeostasis. These results reveal a novel pathway that contributes to the regulation of AQP2\u2013mediated water reabsorption and suggest new potential therapeutic strategies for NDI treatment.<\/jats:p>","DOI":"10.1681\/asn.2015080903","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T23:08:59Z","timestamp":1457564939000},"page":"3105-3116","source":"Crossref","is-referenced-by-count":50,"title":["EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2\u2013Mediated Renal Water Reabsorption"],"prefix":"10.1681","volume":"27","author":[{"given":"Pui W.","family":"Cheung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil V.","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nutthapoom","family":"Pathomthongtaweechai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Ueberdiek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua A. Jenny","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bouley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,3,9]]},"reference":[{"key":"B1-20231016","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1681\/ASN.V114764","article-title":"Homer W. Smith award lecture. Aquaporin water channels in kidney.","volume":"11","author":"Agre","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"B2-20231016","doi-asserted-by":"crossref","first-page":"F317","DOI":"10.1152\/ajprenal.2000.278.2.F317","article-title":"Recycling of AQP2 occurs through a temperature- and bafilomycin-sensitive trans-Golgi-associated compartment.","volume":"278","author":"Gustafson","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"B3-20231016","doi-asserted-by":"crossref","first-page":"F233","DOI":"10.1152\/ajprenal.00179.2003","article-title":"Inhibition of endocytosis causes phosphorylation (S256)-independent plasma membrane accumulation of AQP2.","volume":"286","author":"Lu","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"B4-20231016","doi-asserted-by":"crossref","first-page":"F290","DOI":"10.1152\/ajprenal.00072.2008","article-title":"The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells.","volume":"295","author":"Lu","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"B5-20231016","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1083\/jcb.151.4.919","article-title":"The subcellular localization of an aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers.","volume":"151","author":"Kamsteeg","year":"2000","journal-title":"J Cell Biol"},{"key":"B6-20231016","doi-asserted-by":"crossref","first-page":"186","DOI":"10.7326\/0003-4819-144-3-200602070-00007","article-title":"Nephrogenic diabetes insipidus.","volume":"144","author":"Sands","year":"2006","journal-title":"Ann Intern Med"},{"key":"B7-20231016","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1681\/ASN.V103666","article-title":"Lithium intoxication.","volume":"10","author":"Timmer","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"B8-20231016","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0272-6386(87)80098-7","article-title":"Prevalence, pathogenesis, and treatment of renal dysfunction associated with chronic lithium therapy.","volume":"10","author":"Boton","year":"1987","journal-title":"Am J Kidney Dis"},{"key":"B9-20231016","doi-asserted-by":"crossref","first-page":"F309","DOI":"10.1152\/ajprenal.00001.2011","article-title":"Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase.","volume":"301","author":"Li","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"B10-20231016","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/jcmm.12422","article-title":"A novel therapeutic effect of statins on nephrogenic diabetes insipidus.","volume":"19","author":"Bonfrate","year":"2015","journal-title":"J Cell Mol Med"},{"key":"B11-20231016","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1681\/ASN.2009121267","article-title":"Calcitonin has a vasopressin-like effect on aquaporin-2 trafficking and urinary concentration.","volume":"22","author":"Bouley","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"B12-20231016","doi-asserted-by":"crossref","first-page":"F702","DOI":"10.1152\/ajprenal.00366.2007","article-title":"Treating lithium-induced nephrogenic diabetes insipidus with a COX-2 inhibitor improves polyuria via upregulation of AQP2 and NKCC2.","volume":"294","author":"Kim","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"B13-20231016","doi-asserted-by":"crossref","first-page":"F1103","DOI":"10.1152\/ajprenal.00337.2004","article-title":"Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra).","volume":"288","author":"Bouley","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"B14-20231016","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1681\/ASN.2013111234","article-title":"A protein kinase A-independent pathway controlling aquaporin 2 trafficking as a possible cause for the syndrome of inappropriate antidiuresis associated with polycystic kidney disease 1 haploinsufficiency.","volume":"25","author":"Tamma","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"B15-20231016","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1159\/000373933","article-title":"Rosiglitazone promotes AQP2 plasma membrane expression in renal cells via a Ca-dependent\/cAMP-independent mechanism.","volume":"35","author":"Procino","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"B16-20231016","doi-asserted-by":"crossref","first-page":"C597","DOI":"10.1152\/ajpcell.00154.2014","article-title":"High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration.","volume":"307","author":"Nomura","year":"2014","journal-title":"Am J Physiol Cell Physiol"},{"key":"B17-20231016","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1113\/jphysiol.1994.sp020168","article-title":"Epidermal growth factor as a diuretic in sheep.","volume":"477","author":"Gow","year":"1994","journal-title":"J Physiol"},{"issue":"Suppl 1","key":"B18-20231016","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.3747\/co.19.1114","article-title":"Treatment paradigms for patients with metastatic non-small-cell lung cancer: First-, second-, and third-line.","volume":"19","author":"Leighl","year":"2012","journal-title":"Curr Oncol"},{"key":"B19-20231016","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/1758834011427927","article-title":"Erlotinib in the treatment of advanced non-small cell lung cancer: An update for clinicians.","volume":"4","author":"Wang","year":"2012","journal-title":"Ther Adv Med Oncol"},{"key":"B20-20231016","doi-asserted-by":"crossref","first-page":"F553","DOI":"10.1152\/ajprenal.00438.2011","article-title":"Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin.","volume":"304","author":"Bouley","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"B21-20231016","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1172\/JCI9594","article-title":"Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells.","volume":"106","author":"Bouley","year":"2000","journal-title":"J Clin Invest"},{"key":"B22-20231016","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000169097","article-title":"Effects of high glucose culture on EGF effects and EGF receptors in the LLC-PK1 cells.","volume":"17","author":"Yang","year":"1997","journal-title":"Am J Nephrol"},{"key":"B23-20231016","first-page":"4886","article-title":"Epidermal growth factor-induced mitogenesis in kidney epithelial cells (LLC-PK1).","volume":"48","author":"Mullin","year":"1988","journal-title":"Cancer Res"},{"key":"B24-20231016","doi-asserted-by":"crossref","first-page":"C1476","DOI":"10.1152\/ajpcell.00344.2008","article-title":"A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2.","volume":"295","author":"Nunes","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"B25-20231016","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/MNH.0b013e3283094eb1","article-title":"Phosphorylation events and the modulation of aquaporin 2 cell surface expression.","volume":"17","author":"Brown","year":"2008","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"B26-20231016","doi-asserted-by":"crossref","first-page":"e32843","DOI":"10.1371\/journal.pone.0032843","article-title":"Differential, phosphorylation dependent trafficking of AQP2 in LLC-PK1 cells.","volume":"7","author":"Rice","year":"2012","journal-title":"PLoS One"},{"key":"B27-20231016","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/bj3510095","article-title":"Specificity and mechanism of action of some commonly used protein kinase inhibitors.","volume":"351","author":"Davies","year":"2000","journal-title":"Biochem J"},{"key":"B28-20231016","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35085068","article-title":"Transcriptional regulation by the phosphorylation-dependent factor CREB.","volume":"2","author":"Mayr","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B29-20231016","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1210\/er.2012-1044","article-title":"Nephrogenic diabetes insipidus: Essential insights into the molecular background and potential therapies for treatment.","volume":"34","author":"Moeller","year":"2013","journal-title":"Endocr Rev"},{"key":"B30-20231016","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s40263-014-0152-8","article-title":"Role of lithium augmentation in the management of major depressive disorder.","volume":"28","author":"Bauer","year":"2014","journal-title":"CNS Drugs"},{"key":"B31-20231016","doi-asserted-by":"crossref","first-page":"935","DOI":"10.4088\/JCP.v68n0617","article-title":"Acceleration and augmentation of antidepressants with lithium for depressive disorders: Two meta-analyses of randomized, placebo-controlled trials.","volume":"68","author":"Crossley","year":"2007","journal-title":"J Clin Psychiatry"},{"key":"B32-20231016","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000314308","article-title":"Lithium\u2019s emerging role in the treatment of refractory major depressive episodes: Augmentation of antidepressants.","volume":"62","author":"Bauer","year":"2010","journal-title":"Neuropsychobiology"},{"key":"B33-20231016","first-page":"CD003834","article-title":"Lithium for schizophrenia.","volume":"3","author":"Leucht","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"B34-20231016","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0165-0327(02)00354-3","article-title":"Prophylaxis of schizoaffective disorder with lithium or carbamazepine: Outcome after long-term follow-up.","volume":"79","author":"Baethge","year":"2004","journal-title":"J Affect Disord"},{"key":"B36-20231016","first-page":"104","article-title":"Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer\u2019s disease.","volume":"10","author":"Nunes","year":"2013","journal-title":"Curr Alzheimer Res"},{"key":"B37-20231016","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1681\/ASN.2010070734","article-title":"alphaENaC-mediated lithium absorption promotes nephrogenic diabetes insipidus.","volume":"22","author":"Christensen","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"B38-20231016","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/ki.2009.91","article-title":"Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus.","volume":"76","author":"Kortenoeven","year":"2009","journal-title":"Kidney Int"},{"key":"B39-20231016","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1210\/endo-107-6-1693","article-title":"Lithium-induced polyuria: Effect of lithium on adenylate cyclase and adenosine 3\u2032,5\u2032-monophosphate phosphodiesterase in medullary ascending limb of Henle\u2019s loop and in medullary collecting tubules.","volume":"107","author":"Jackson","year":"1980","journal-title":"Endocrinology"},{"key":"B40-20231016","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1681\/ASN.2005080884","article-title":"Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylyl cyclase activity.","volume":"17","author":"Li","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"B41-20231016","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1073\/pnas.0800001105","article-title":"Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: Mechanisms for aquaporin 2 down-regulation and cellular proliferation.","volume":"105","author":"Nielsen","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B42-20231016","doi-asserted-by":"crossref","first-page":"C952","DOI":"10.1152\/ajpcell.00266.2003","article-title":"Changes in cellular composition of kidney collecting duct cells in rats with lithium-induced NDI.","volume":"286","author":"Christensen","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"B43-20231016","first-page":"63","article-title":"Treatment of congenital nephrogenic diabetes insipidus with hydrochlorothiazide and amiloride in an adult patient.","volume":"61","author":"Konoshita","year":"2004","journal-title":"Horm Res"},{"key":"B44-20231016","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1136\/adc.80.6.548","article-title":"Treatment of nephrogenic diabetes insipidus with hydrochlorothiazide and amiloride.","volume":"80","author":"Kirchlechner","year":"1999","journal-title":"Arch Dis Child"},{"key":"B45-20231016","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0022-3476(05)81106-0","article-title":"Amiloride-hydrochlorothiazide versus indomethacin-hydrochlorothiazide in the treatment of nephrogenic diabetes insipidus.","volume":"117","author":"Knoers","year":"1990","journal-title":"J Pediatr"},{"key":"B46-20231016","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000166896","article-title":"Hydrochlorothiazide-amiloride in the treatment of congenital nephrogenic diabetes insipidus.","volume":"5","author":"Alon","year":"1985","journal-title":"Am J Nephrol"},{"key":"B47-20231016","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/BF00852546","article-title":"Successful treatment with hydrochlorothiazide and amiloride in an infant with congenital nephrogenic diabetes insipidus.","volume":"7","author":"Uyeki","year":"1993","journal-title":"Pediatr Nephrol"},{"key":"B48-20231016","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1001\/archinte.1997.00440330027003","article-title":"The management of diabetes insipidus in adults.","volume":"157","author":"Singer","year":"1997","journal-title":"Arch Intern Med"},{"key":"B49-20231016","first-page":"2146","article-title":"Evaluation and management of diabetes insipidus.","volume":"55","author":"Adam","year":"1997","journal-title":"Am Fam Physician"},{"key":"B50-20231016","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.semnephrol.2008.03.010","article-title":"Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus.","volume":"28","author":"Bouley","year":"2008","journal-title":"Semin Nephrol"},{"key":"B51-20231016","doi-asserted-by":"crossref","first-page":"F216","DOI":"10.1152\/ajprenal.00439.2010","article-title":"Sildenafil reduces polyuria in rats with lithium-induced NDI.","volume":"302","author":"Sanches","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"B52-20231016","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1007\/s00467-005-2057-8","article-title":"Efficacy of COX-2 inhibitors in a case of congenital nephrogenic diabetes insipidus.","volume":"20","author":"Soylu","year":"2005","journal-title":"Pediatr Nephrol"},{"key":"B53-20231016","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s00467-003-1195-0","article-title":"Treatment of congenital nephrogenic diabetes insipidus by hydrochlorothiazide and cyclooxygenase-2 inhibitor.","volume":"18","author":"Pattaragarn","year":"2003","journal-title":"Pediatr Nephrol"},{"key":"B54-20231016","doi-asserted-by":"crossref","first-page":"e54738","DOI":"10.1371\/journal.pone.0054738","article-title":"Erlotinib preserves renal function and prevents salt retention in doxorubicin treated nephrotic rats.","volume":"8","author":"Bou Matar","year":"2013","journal-title":"PLoS One"},{"key":"B55-20231016","first-page":"F817","article-title":"Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells.","volume":"272","author":"Katsura","year":"1997","journal-title":"Am J Physiol"},{"key":"B57-20231016","first-page":"336","article-title":"Vasopressin stimulates endocytosis in kidney collecting duct principal cells.","volume":"46","author":"Brown","year":"1988","journal-title":"Eur J Cell Biol"},{"key":"B58-20231016","doi-asserted-by":"crossref","first-page":"14800","DOI":"10.1074\/jbc.272.23.14800","article-title":"Phosphorylation of serine 256 is required for cAMP-dependent regulatory exocytosis of the aquaporin-2 water channel.","volume":"272","author":"Fushimi","year":"1997","journal-title":"J Biol Chem"},{"key":"B59-20231016","doi-asserted-by":"crossref","first-page":"28721","DOI":"10.1074\/jbc.M611101200","article-title":"Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking.","volume":"282","author":"Lu","year":"2007","journal-title":"J Biol Chem"},{"key":"B60-20231016","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1073\/pnas.0910683107","article-title":"Phosphorylation of aquaporin-2 regulates its endocytosis and protein-protein interactions.","volume":"107","author":"Moeller","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B61-20231016","doi-asserted-by":"crossref","first-page":"24617","DOI":"10.1074\/jbc.M803074200","article-title":"Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2.","volume":"283","author":"Hoffert","year":"2008","journal-title":"J Biol Chem"},{"key":"B62-20231016","doi-asserted-by":"crossref","first-page":"40777","DOI":"10.1074\/jbc.M110.151928","article-title":"Phosphorylation of aquaporin-2 regulates its water permeability.","volume":"285","author":"Eto","year":"2010","journal-title":"J Biol Chem"},{"key":"B63-20231016","doi-asserted-by":"crossref","first-page":"F691","DOI":"10.1152\/ajprenal.00284.2006","article-title":"Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct.","volume":"292","author":"Hoffert","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"B64-20231016","doi-asserted-by":"crossref","first-page":"F1030","DOI":"10.1152\/ajprenal.90339.2008","article-title":"Akt and ERK1\/2 pathways are components of the vasopressin signaling network in rat native IMCD.","volume":"295","author":"Pisitkun","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"B65-20231016","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev.pharmtox.44.101802.121440","article-title":"ErbB receptors: Directing key signaling networks throughout life.","volume":"44","author":"Holbro","year":"2004","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"B66-20231016","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/ki.2012.435","article-title":"Role of epidermal growth factor receptor in acute and chronic kidney injury.","volume":"83","author":"Tang","year":"2013","journal-title":"Kidney Int"},{"key":"B67-20231016","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/HYPERTENSIONAHA.108.113860","article-title":"Epidermal growth factor receptor signaling in the kidney: Key roles in physiology and disease.","volume":"52","author":"Melenhorst","year":"2008","journal-title":"Hypertension"},{"key":"B68-20231016","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1111\/j.1523-1755.2004.00623.x","article-title":"EGF-related growth factors in the pathogenesis of murine ARPKD.","volume":"65","author":"MacRae Dell","year":"2004","journal-title":"Kidney Int"},{"key":"B69-20231016","doi-asserted-by":"crossref","first-page":"F12","DOI":"10.1152\/ajprenal.00112.2013","article-title":"Epidermal growth factors in the kidney and relationship to hypertension.","volume":"305","author":"Staruschenko","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"B70-20231016","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.2217\/pgs.13.184","article-title":"Renal cell carcinoma development and miRNAs: A possible link to the EGFR pathway.","volume":"14","author":"Dias","year":"2013","journal-title":"Pharmacogenomics"},{"key":"B71-20231016","doi-asserted-by":"crossref","first-page":"e0103258","DOI":"10.1371\/journal.pone.0103258","article-title":"Combined influence of EGF+61G>A and TGFB+869T>C functional polymorphisms in renal cell carcinoma progression and overall survival: The link to plasma circulating MiR-7 and MiR-221\/222 expression.","volume":"10","author":"Teixeira","year":"2014","journal-title":"PLoS One"},{"key":"B72-20231016","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1002\/cncr.26436","article-title":"Epidermal growth factor receptor protein expression and genomic alterations in renal cell carcinoma.","volume":"118","author":"Minner","year":"2012","journal-title":"Cancer"},{"key":"B73-20231016","doi-asserted-by":"crossref","first-page":"F1417","DOI":"10.1152\/ajprenal.90337.2008","article-title":"Biphasic regulation of ENaC by TGF-alpha and EGF in renal epithelial cells.","volume":"296","author":"Liu","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"issue":"Suppl 1","key":"B74-20231016","doi-asserted-by":"crossref","first-page":"i15","DOI":"10.1093\/ndtplus\/sfr164","article-title":"Regulation of magnesium balance: Lessons learned from human genetic disease.","volume":"5","author":"de Baaij","year":"2012","journal-title":"Clin Kidney J"},{"key":"B75-20231016","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1172\/JCI31680","article-title":"Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia.","volume":"117","author":"Groenestege","year":"2007","journal-title":"J Clin Invest"},{"key":"B76-20231016","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1172\/JCI119386","article-title":"Production of heparin binding epidermal growth factor-like growth factor in the early phase of regeneration after acute renal injury. Isolation and localization of bioactive molecules.","volume":"99","author":"Sakai","year":"1997","journal-title":"J Clin Invest"},{"key":"B77-20231016","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1042\/cs0780445","article-title":"Epidermal growth factor accelerates functional recovery from ischaemic acute tubular necrosis in the rat: Role of the epidermal growth factor receptor.","volume":"78","author":"Norman","year":"1990","journal-title":"Clin Sci (Lond)"},{"key":"B78-20231016","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1097\/01.ASN.0000098681.56240.1A","article-title":"Importance of functional EGF receptors in recovery from acute nephrotoxic injury.","volume":"14","author":"Wang","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"B79-20231016","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000045962","article-title":"Control of the epidermal growth factor receptor and its ligands during renal injury.","volume":"88","author":"Hise","year":"2001","journal-title":"Nephron"},{"key":"B80-20231016","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1172\/JCI113732","article-title":"Epidermal growth factor inhibits the hydroosmotic effect of vasopressin in the isolated perfused rabbit cortical collecting tubule.","volume":"82","author":"Breyer","year":"1988","journal-title":"J Clin Invest"},{"key":"B81-20231016","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1681\/ASN.2009070719","article-title":"Targeted inactivation of EGF receptor inhibits renal collecting duct development and function.","volume":"21","author":"Zhang","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"B82-20231016","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1042\/BC20040054","article-title":"Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in \u2018endocytosis-resistant\u2019 membrane domains after vasopressin treatment.","volume":"98","author":"Bouley","year":"2006","journal-title":"Biol Cell"},{"key":"B83-20231016","doi-asserted-by":"crossref","first-page":"C38","DOI":"10.1152\/ajpcell.00109.2012","article-title":"Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel.","volume":"304","author":"Yui","year":"2013","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201610000-00021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:27:38Z","timestamp":1786130858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201610000-00021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,9]]},"references-count":81,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2015080903","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726228021.793516006","asserted-by":"object"}]},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,9]]}}}