{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:35:29Z","timestamp":1791408929013,"version":"4.3.3"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>FSGS is a common glomerular disorder that has a high propensity for recurrence after kidney transplant. The pathophysiology of FSGS is unknown, but podocytes seem to be the target of one or several circulating factors that lead to cytoskeleton reorganization and proteinuria. Research on podocytes has identified B7\u20131 as an important factor in podocyte biology and a new therapeutic target in renal disease. Indeed, in four patients with recurrent FSGS after transplant, treatment with the B7\u20131 blocker abatacept was associated with proteinuria remission. Here, we prospectively treated nine patients with recurrent FSGS after transplant using either abatacept or belatacept, a B7\u20131 blocker with higher affinity, and did not induce proteinuria remission. Furthermore, we did not detect B7\u20131 expression by immunofluorescence in podocytes of biopsy specimens from these or other kidney grafts or podocytes of native kidney biopsy specimens. In conclusion, B7\u20131 blockade did not induce FSGS remission after transplant in our study.<\/jats:p>","DOI":"10.1681\/asn.2015091002","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T23:05:25Z","timestamp":1450911925000},"page":"2520-2527","source":"Crossref","is-referenced-by-count":83,"title":["B7\u20131 Blockade Does Not Improve Post\u2013Transplant Nephrotic Syndrome Caused by Recurrent FSGS"],"prefix":"10.1681","volume":"27","author":[{"given":"Marianne","family":"Delville","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9,"},{"name":"Service de Bioth\u00e9rapie,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Baye","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, Institut Necker Enfants Malades,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Durrbach","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie et Transplantation, H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale 1197, Universit\u00e9 Paris-Saclay, Le Kremlin Bic\u00eatre, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Audard","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier Henri Mondor Albert Chenevier, Service de N\u00e9phrologie et Transplantation, Universit\u00e9 Paris Est Cr\u00e9teil, Creteil, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomek","family":"Kofman","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier Henri Mondor Albert Chenevier, Service de N\u00e9phrologie et Transplantation, Universit\u00e9 Paris Est Cr\u00e9teil, Creteil, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Braun","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie et Transplantation, H\u00f4pitaux Universitaires de Strasbourg, Nouvel H\u00f4pital Civil, Strasbourg, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Olagne","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie et Transplantation, H\u00f4pitaux Universitaires de Strasbourg, Nouvel H\u00f4pital Civil, Strasbourg, France;"},{"name":"Laboratoire d'Anatomo-Pathologie, H\u00f4pitaux Universitaires de Strasbourg, H\u00f4pital de Hautepierre, Strasbourg, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, Institut Necker Enfants Malades,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Desch\u00eanes","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie p\u00e9diatrique, H\u00f4pital Robert Debr\u00e9, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Moulin","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie et Transplantation, H\u00f4pitaux Universitaires de Strasbourg, Nouvel H\u00f4pital Civil, Strasbourg, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Delahousse","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie Transplantation, H\u00f4pital Foch, Suresnes, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwena\u00eblle","family":"Kesler-Roussey","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie p\u00e9diatrique, Centre Hospitalier Universitaire de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Beaudreuil","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie et Transplantation, H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale 1197, Universit\u00e9 Paris-Saclay, Le Kremlin Bic\u00eatre, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Martinez","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie Transplantation Adultes, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Rabant","sequence":"additional","affiliation":[{"name":"Service d\u2019Anatomie et Cytologie Pathologiques, H\u00f4pital Necker-Enfants Malades, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Grimbert","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier Henri Mondor Albert Chenevier, Service de N\u00e9phrologie et Transplantation, Universit\u00e9 Paris Est Cr\u00e9teil, Creteil, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Gallazzini","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9,"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, Institut Necker Enfants Malades,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Terzi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9,"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1151, Institut Necker Enfants Malades,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Legendre","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris 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