{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:14:47Z","timestamp":1789906487722,"version":"4.0.1"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>\n                    Vascular endothelial growth factor (VEGF) is implicated in the peritoneal membrane remodeling that limits ultrafiltration in patients on peritoneal dialysis (PD). Although the exact mechanism of VEGF induction in PD is unclear, VEGF concentrations in drained dialysate correlate with IL-6 levels, suggesting a link between these cytokines. Human peritoneal mesothelial cells (HPMCs), the main source of IL-6 and VEGF in the peritoneum, do not bear the cognate IL-6 receptor and are thus unable to respond to classic IL-6 receptor signaling. Here, we investigated whether VEGF release by HPMCs is controlled by IL-6 in combination with its soluble receptor (IL-6 trans\u2013signaling). Although treatment with either IL-6 or soluble IL-6 receptor (sIL-6R) alone had no effect on VEGF production, stimulation of HPMCs with IL-6 in combination with sIL-6R promoted VEGF expression and secretion through a transcriptional mechanism involving STAT3 and SP4. Conditioned medium from HPMCs cultured with IL-6 and sIL-6R promoted angiogenic endothelial tube formation, which could be blocked by silencing SP4.\n                    <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                    , induction of peritoneal inflammation in wild-type and IL-6\u2013deficient mice showed IL-6 involvement in the control of\n                    <jats:italic toggle=\"yes\">Sp4<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Vegf<\/jats:italic>\n                    expression and new vessel formation, confirming the role of IL-6 trans\u2013signaling in these processes. Taken together, these findings identify a novel mechanism linking IL-6 trans\u2013signaling and angiogenesis in the peritoneal membrane.\n                  <\/jats:p>","DOI":"10.1681\/asn.2015101169","type":"journal-article","created":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T22:43:34Z","timestamp":1478904214000},"page":"1188-1199","source":"Crossref","is-referenced-by-count":83,"title":["IL-6 Trans\u2013Signaling Links Inflammation with Angiogenesis in the Peritoneal Membrane"],"prefix":"10.1681","volume":"28","author":[{"given":"Rusan","family":"Catar","sequence":"first","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany;"},{"name":"Berlin Institute of Health, Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Witowski","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany;"},{"name":"Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"L\u00fccht","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Derrac Soria","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Uceda Fernandez","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceri A.","family":"Fielding","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Rudolf","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, 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