{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:47:06Z","timestamp":1790192826254,"version":"4.1.0"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>\n                    The demonstration of impaired C regulation in the thrombotic microangiopathy (TMA) atypical hemolytic uremic syndrome (aHUS) resulted in the successful introduction of the C inhibitor eculizumab into clinical practice. C abnormalities account for approximately 50% of aHUS cases; however, mutations in the non-C gene diacylglycerol kinase-\n                    <jats:italic toggle=\"yes\">\u03b5<\/jats:italic>\n                    have been described recently in individuals not responsive to eculizumab. We report here a family in which the proposita presented with aHUS but did not respond to eculizumab. Her mother had previously presented with a post\u2013renal transplant TMA. Both the proposita and her mother also had Charcot\u2013Marie\u2013Tooth disease. Using whole-exome sequencing, we identified a mutation in the inverted formin 2 gene (\n                    <jats:italic toggle=\"yes\">INF2<\/jats:italic>\n                    ) in the mutational hotspot for FSGS. Subsequent analysis of the Newcastle aHUS cohort identified another family with a functionally-significant mutation in\n                    <jats:italic toggle=\"yes\">INF2<\/jats:italic>\n                    . In this family, renal transplantation was associated with post-transplant TMA. All individuals with\n                    <jats:italic toggle=\"yes\">INF2<\/jats:italic>\n                    mutations presenting with a TMA also had aHUS risk haplotypes, potentially accounting for the genetic pleiotropy. Identifying individuals with TMAs who may not respond to eculizumab will avoid prolonged exposure of such individuals to the infectious complications of terminal pathway C blockade.\n                  <\/jats:p>","DOI":"10.1681\/asn.2015101189","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T20:44:53Z","timestamp":1481748293000},"page":"1084-1091","source":"Crossref","is-referenced-by-count":52,"title":["Thrombotic Microangiopathy in Inverted Formin 2\u2013Mediated Renal Disease"],"prefix":"10.1681","volume":"28","author":[{"given":"Rachel C.","family":"Challis","sequence":"first","affiliation":[{"name":"National Renal Complement Therapeutics Centre, Institutes of *Genetic Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troels","family":"Ring","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Aalborg University Hospital and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaobo","family":"Xu","sequence":"additional","affiliation":[{"name":"National Renal Complement Therapeutics Centre, Institutes of *Genetic Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin K.S.","family":"Wong","sequence":"additional","affiliation":[{"name":"National Renal Complement Therapeutics Centre, Institutes of *Genetic Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Flossmann","sequence":"additional","affiliation":[{"name":"Renal Unit, Royal Berkshire Hospital, Reading, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian S.D.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, Oxford University Hospitals National Health Service Trust, Oxford, United 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and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Fester","sequence":"additional","affiliation":[{"name":"Egton Surgery, Whitby, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Strain","sequence":"additional","affiliation":[{"name":"National Renal Complement Therapeutics Centre, Northern Molecular Genetics Service and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Wilson","sequence":"additional","affiliation":[{"name":"National Renal Complement Therapeutics Centre, Northern Molecular Genetics Service and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina M.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin 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