{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:03:57Z","timestamp":1790276637786,"version":"4.1.0"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>\n                    An individual\u2019s immune function, susceptibility to infection, and response to immunosuppressive therapy are influenced in part by his\/her T cell maturation state. Although childhood is the most dynamic period of immune maturation, scant information regarding the variability of T cell maturation in children with renal disease is available. In this study, we compared the T cell phenotype in children with renal failure (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =80) with that in healthy children (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =20) using multiparameter flow cytometry to detect markers of T cell maturation, exhaustion, and senescence known to influence immune function. We correlated data with the degree of renal failure (dialysis or nondialysis), prior immunosuppression use, and markers of inflammation (C-reactive protein and inflammatory cytokines) to assess the influence of these factors on T cell phenotype. Children with renal disease had highly variable and often markedly skewed maturation phenotypes, including CD4\/CD8 ratio reversal, increased terminal effector differentiation in CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, reduction in the proportion of na\u00efve T cells, evidence of T cell exhaustion and senescence, and variable loss of T cell CD28 expression. These findings were most significant in patients who had experienced major immune insults, particularly prior immunosuppressive drug exposure. In conclusion, children with renal disease have exceptional heterogeneity in the T cell repertoire. Cognizance of this heterogeneity might inform risk stratification with regard to the balance between infectious risk and response to immunosuppressive therapy, such as that required for autoimmune disease and transplantation.\n                  <\/jats:p>","DOI":"10.1681\/asn.2016010053","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T02:14:24Z","timestamp":1468462464000},"page":"359-367","source":"Crossref","is-referenced-by-count":64,"title":["Premature T Cell Senescence in Pediatric CKD"],"prefix":"10.1681","volume":"28","author":[{"given":"Roshan P.","family":"George","sequence":"first","affiliation":[{"name":"Division of Pediatric Nephrology, Department of Pediatrics, Children\u2019s Healthcare of Atlanta, Atlanta, Georgia;"},{"name":"Division of Pediatric Nephrology, Department of Pediatrics, Emory Transplant Center, Emory University, Atlanta, Georgia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneesh K.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Department of Pediatrics, Emory Transplant Center, Emory University, Atlanta, Georgia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian D.","family":"Perez","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Department of Pediatrics, Emory Transplant Center, Emory University, Atlanta, Georgia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Winterberg","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Department of Pediatrics, Children\u2019s Healthcare of Atlanta, Atlanta, Georgia;"},{"name":"Division of Pediatric Nephrology, Department of Pediatrics, Emory Transplant Center, Emory University, Atlanta, Georgia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Cheeseman","sequence":"additional","affiliation":[{"name":"Division of Surgery, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandi","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Department of Pediatrics, Emory Transplant Center, Emory University, Atlanta, Georgia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Kwun","sequence":"additional","affiliation":[{"name":"Division of Surgery, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Monday","sequence":"additional","affiliation":[{"name":"Division of Surgery, Duke University, Durham, North 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